| Title: |
Handgrip strength and health outcomes: Umbrella review of systematic reviews with meta-analyses of observational studies. |
| Authors: |
Soysal, P; Hurst, C; Demurtas, J; Firth, J; Howden, R; Yang, L; Tully, MA; Koyanagi, A; Ilie, PC; López-Sánchez, GF; Schwingshackl, L; Veronese, N; Smith, L |
| Source: |
Soysal, P, Hurst, C, Demurtas, J, Firth, J, Howden, R, Yang, L, Tully, MA, Koyanagi, A, Ilie, PC, López-Sánchez, GF, Schwingshackl, L, Veronese, N & Smith, L 2020, 'Handgrip strength and health outcomes: Umbrella review of systematic reviews with meta-analyses of observational studies.', Journal of sport and health science. https://doi.org/10.1016/j.jshs.2020.06.009 |
| Publication Year: |
2020 |
| Collection: |
The University of Manchester: Research Explorer - Publications |
| Description: |
Purpose The aim of the present study was to assess both the credibility and strength of evidence arising from systematic reviews with meta-analyses of observational studies on handgrip strength and health outcomes. Methods An umbrella review of systematic reviews with meta-analyses of observational studies was conducted. We assessed meta-analyses of observational studies based on random-effect summary effect sizes and their p values, 95% prediction intervals, heterogeneity, small-study effects, and excess significance. We graded the evidence from convincing (Class I) to weak (Class IV). Results From 504 articles returned in a search of the literature, 8 systematic reviews were included in our review, with a total of 11 outcomes. Overall, 9 of the 11 of the outcomes reported nominally significant summary results (p < 0.05), with 4 associations surviving the application of the more stringent p value (p < 10−6). No outcome presented convincing evidence. Three associations showed Class II evidence (i.e., highly suggestive): (1) higher handgrip values at baseline were associated with a minor reduction in mortality risk in the general population (n = 34 studies; sample size = 1,855,817; relative risk = 0.72; 95% confidence interval (CI): 0.67–0.78), (2) cardiovascular death risk in mixed populations (n = 15 studies; relative risk = 0.84; 95%CI: 0.78–0.91), and (3) incidence of disability (n = 7 studies; relative risk = 0.76; 95%CI: 0.66–0.87). Conclusion The present results show that handgrip strength is a useful indicator for general health status and specifically for early all-cause and cardiovascular mortality, as well as disability. To further inform intervention strategies, future research is now required to fully understand mechanisms linking handgrip strength scores to these health outcomes. |
| Document Type: |
article in journal/newspaper |
| Language: |
unknown |
| ISSN: |
2213-2961 |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/32565244; info:eu-repo/semantics/altIdentifier/eissn/2213-2961 |
| DOI: |
10.1016/j.jshs.2020.06.009 |
| Availability: |
https://research.manchester.ac.uk/en/publications/a04ac395-ac00-4361-acdd-775d86eea7f5; https://doi.org/10.1016/j.jshs.2020.06.009; https://www.scopus.com/pages/publications/85088393827 |
| Rights: |
info:eu-repo/semantics/openAccess |
| Accession Number: |
edsbas.B06FB5D4 |
| Database: |
BASE |