| Title: |
p38-MAPK and PKB/Akt, possible role players in red palm oil-induced protection of the isolated perfused rat heart? |
| Authors: |
Engelbrecht, AM; Esterhuyse, J; Du Toit, EF; Lochner, A; Van Rooyen, J |
| Publisher Information: |
Elsevier Science |
| Publication Year: |
2006 |
| Collection: |
Griffith University: Griffith Research Online |
| Subject Terms: |
Biochemistry and cell biology; Food sciences; Cardiology (incl. cardiovascular diseases); Nutrition and dietetics |
| Description: |
It has been shown that dietary red palm oil (RPO) supplementation improves reperfusion function. However, no exact protective cellular mechanisms have been established. To determine a potential mechanism for functional improvement, we examined the regulation of both mitogen-activated protein kinases (MAPKs) and PKB/Akt in the presence and absence of dietary RPO supplementation in ischemia/reperfusion-induced injury. Wistar rats were fed a control diet or control diet plus 7 g RPO/kg diet for 6 weeks. Hearts were excised and mounted on an isolated working heart perfusion apparatus. Cardiac function was measured before and after hearts were subjected to 25 min of total global ischemia. Hearts subjected to the same conditions were freeze clamped and used to characterize the degree of phosphorylation of extracellular signal-regulated kinase, p38, c-Jun NH2-terminal protein kinase (JNK) and PKB/Akt. Dietary RPO supplementation significantly improved aortic output recovery (72.1ᳮ2% vs. 54.0ᳮ2%, P |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
Journal of Nutritional Biochemistry; http://www.sciencedirect.com/science/journal/09552863; https://hdl.handle.net/10072/27480 |
| DOI: |
10.1016/j.jnutbio.2005.05.001 |
| Availability: |
https://hdl.handle.net/10072/27480; https://doi.org/10.1016/j.jnutbio.2005.05.001 |
| Accession Number: |
edsbas.B0948F98 |
| Database: |
BASE |