Metabolic Syndrome (MetS), Systemic Inflammatory Response Syndrome (SIRS), and Frailty: Is There any Room for Good Outcome in the Elderly Undergoing Emergency Surgery?
| Title: | Metabolic Syndrome (MetS), Systemic Inflammatory Response Syndrome (SIRS), and Frailty: Is There any Room for Good Outcome in the Elderly Undergoing Emergency Surgery? |
|---|---|
| Authors: | Fransvea P.; Costa G.; Lepre L.; Capolupo G. T.; Carannante F.; Puccioni C.; Costa A.; La Greca A.; Giovinazzo F.; Sganga on behalf of the IGo-GIPS study group (G. Agresta F; Alemanno G; Antropoli M; Argenio G; Atzeni J; Avenia N; Azzinnaro A; Baldazzi G; Barbera G; Bergamini C; Bombardini C; Borzellino G; Bozzo S; Brachini G; Buonanno GM; Canini T; Capolupo GT; Carannante F; Cardella S; Caricato M; Carrara G; Cassini D; Castriconi M; Ceccarelli G; Celi D; Ceresoli M; Chiarugi M; Cillara N; Cimino F; Cobuccio L; Cocorullo G; Colangelo E; Costa G; Crucitti A; Cucinotta E; D’Alessio R; Dalla Caneva P; de Manzoni Garberini A; De Nisco C; De Prizio M; De Sol A; Dibella A; Falcioni T; Falco N; Farina C; Finotti E; Fontana T; Francioni G; Fransvea P; Frezza B; Garbarino GM; Garulli G; Genna M; Giannessi S; Gioffrè A; Giordano A; Gozzo D; Grimaldi S; Gulotta G; Iacopini V; Iarussi T; Kurihara H; Laracca GG; Laterza E; Leonardi A; Lepre L; Luridiana G; Malagnino A; Mar G; Marini P; Mariani D; Marzaioli R; Massa G; Mecarelli V; Mercantini P; Mingoli A; Miranda G; Montuori M; Occhionorelli S; Paderno N; Palini GM; Paradies D; Paroli M; Perrone F; Petruzzelli L; Pezzolla A; Piazza D; Piazza V; Pignata G; Pinotti E; Pisanu A; Podda M; Poillucci G; Porfidia R; Rocca A; Rondelli F; Rossi G; Spagnoli A; Sulis R; Tartaglia D; Tranà C; Travaglino A; Tomaiuolo P; Valeri A; Zago M; Zanoni E. ) |
| Contributors: | Fransvea, P.; Costa, G.; Lepre, L.; Capolupo, G. T.; Carannante, F.; Puccioni, C.; Costa, A.; La Greca, A.; Giovinazzo, F.; Sganga on behalf of the IGo-GIPS study group (G., Agresta F; Alemanno, G; Antropoli, M; Argenio, G; Atzeni, J; Avenia, N; Azzinnaro, A; Baldazzi, G; Barbera, G; Bergamini, C; Bombardini, C; Borzellino, G; Bozzo, S; Brachini, G; Buonanno, Gm; Canini, T; Capolupo, Gt; Carannante, F; Cardella, S; Caricato, M; Carrara, G; Cassini, D; Castriconi, M; Ceccarelli, G; Celi, D; Ceresoli, M; Chiarugi, M; Cillara, N; Cimino, F; Cobuccio, L; Cocorullo, G; Colangelo, E; Costa, G; Crucitti, A; Cucinotta, E; D’Alessio, R; Dalla Caneva, P; de Manzoni Garberini, A; De Nisco, C; De Prizio, M; De Sol, A; Dibella, A; Falcioni, T; Falco, N; Farina, C; Finotti, E; Fontana, T; Francioni, G; Fransvea, P; Frezza, B; Garbarino, Gm; Garulli, G; Genna, M; Giannessi, S; Gioffrè, A; Giordano, A; Gozzo, D; Grimaldi, S; Gulotta, G; Iacopini, V; Iarussi, T; Kurihara, H; Laracca, Gg; Laterza, E; Leonardi, A; Lepre, L; Luridiana, G; Malagnino, A; Mar, G; Marini, P; Mariani, D; Marzaioli, R; Massa, G; Mecarelli, V; Mercantini, P; Mingoli, A; Miranda, G; Montuori, M; Occhionorelli, S; Paderno, N; Palini, Gm; Paradies, D; Paroli, M; Perrone, F; Petruzzelli, L; Pezzolla, A; Piazza, D; Piazza, V; Pignata, G; Pinotti, E; Pisanu, A |
| Publisher Information: | Frontiers Media S.A.; Lausanne, Switzerland |
| Publication Year: | 2022 |
| Collection: | Sapienza Università di Roma: CINECA IRIS |
| Subject Terms: | acute care surgery; elderly; frailty; metabolic syndrome; SIRS |
| Description: | Background: Patients with MetS or SIRS experience higher rates of mortality and morbidity, across both cardiac and noncardiac surgery. Frailty assessment has acquired increasing importance in recent years as it predisposes elderly patients to a worse outcome. The aim of our study was to investigate the influence of MetS, SIRS, and with or without frailty on elderly patients undergoing emergency surgical procedures. Methods: We analyzed data of all patients with nonmalignant diseases requiring an emergency surgical procedure from January 2017 to December 2020. The occurrence of MetS was identified using modified definition criteria used by the NCEP-ATP III Expert Panel: obesity, hypertension, diabetes, or if medication for high triglycerides or for low HDL cholesterol was taken. Systemic inflammatory response syndrome (SIRS) was evaluated according to the original consensus study (Sepsis-1). The frailty profile was investigated by the 5-modified Frailty Index (5-mFI) and the Emergency Surgery Frailty Index (EmSFI). Postoperative complications have been reported and categorized according to the Clavien–Dindo (C–D) classification system. Morbidity and mortality have been mainly considered as the 30-day standard period definition. Results: Of the 2,318 patients included in this study, 1,010 (43.6%) fulfilled the criteria for MetS (MetsG group). Both 5-Items score and EmsFI showed greater fragility in patients with MetS. All patients with MetS showed more frequently a CACI index greater than 6. The occurrence of SIRS was higher in MetSG. LOS was longer in patients with MetS (MetSG 11.4 ± 12 days vs. n-MetSG 10.5 ± 10.2 days, p = 0.046). MetSG has a significantly higher rate of morbidity (353 (35.%) vs. 385 (29.4%), p = 0.005). The mortality rate in patients with MetS (98/1010, 10%) was similar to that in patients without it (129/1308, 10%). Considering patients with MetS who developed SIRS and those who had frailty or both, the occurrence of these conditions was associated with a higher rate of morbidity and ... |
| Document Type: | article in journal/newspaper |
| Language: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/35784911; info:eu-repo/semantics/altIdentifier/wos/WOS:000818373800001; volume:9; numberofpages:9; journal:FRONTIERS IN SURGERY; https://hdl.handle.net/11573/1682192 |
| DOI: | 10.3389/fsurg.2022.870082 |
| Availability: | https://hdl.handle.net/11573/1682192; https://doi.org/10.3389/fsurg.2022.870082 |
| Rights: | info:eu-repo/semantics/openAccess |
| Accession Number: | edsbas.B0A21325 |
| Database: | BASE |