| Title: |
Feasibility of collecting tumor samples of breast cancer patients diagnosed up to 50 years ago in the Child Health and Development Studies |
| Authors: |
Krigbaum, NY; Rubin, RA; Cirillo, PM; Terry, MB; Habel, LA; Morris, C; Cohn, BA |
| Source: |
Journal of Developmental Origins of Health and Disease, vol 8, iss 3 |
| Publisher Information: |
eScholarship, University of California |
| Publication Year: |
2017 |
| Collection: |
University of California: eScholarship |
| Subject Terms: |
4203 Health Services and Systems (for-2020); 32 Biomedical and Clinical Sciences (for-2020); 42 Health Sciences (for-2020); 3211 Oncology and Carcinogenesis (for-2020); Clinical Research (rcdc); Pediatric (rcdc); Women's Health (rcdc); Prevention (rcdc); Breast Cancer (rcdc); Cancer (rcdc); 4.1 Discovery and preclinical testing of markers and technologies (hrcs-rac); Cancer (hrcs-hc); 3 Good Health and Well Being (sdg); Breast Neoplasms (mesh); Child (mesh); Child Development (mesh); Child Health (mesh); Cohort Studies (mesh); Feasibility Studies (mesh); Female (mesh); Follow-Up Studies (mesh); Humans (mesh); Middle Aged (mesh); Pilot Projects (mesh); Prospective Studies (mesh); Registries (mesh); Specimen Handling (mesh); Time Factors (mesh); breast cancer prevention; Child Health and Development Studies |
| Subject Geographic: |
331 - 336 |
| Description: |
Environmental exposures during pregnancy may increase breast cancer risk for mothers and female offspring. Tumor tissue assays may provide insight regarding the mechanisms. This study assessed the feasibility of obtaining tumor samples and pathology reports from mothers (F0) who were enrolled in the Child Health and Development Studies during pregnancy from 1959 to 1967 and their daughters (F1) who developed breast cancer over more than 50 years of follow-up. Breast cancer cases were identified through linkage to the California Cancer Registry and self-report. Written consent was obtained from 116 F0 and 95 F1 breast cancer survivors to access their pathology reports and tumor blocks. Of those contacted, 62% consented, 13% refused and 24% did not respond. We obtained tissue samples for 57% and pathology reports for 75%, and if diagnosis was made ⩽10 years we obtained tissue samples and pathology reports for 91% and 79%, respectively. Obtaining pathology reports and tumor tissues of two generations is feasible and will support investigation of the relationship between early-life exposures and molecular tumor markers. However, we found that more recent diagnosis increased the accessibility of tumor tissue. We recommend that cohorts request consent for obtaining future tumor tissues at study enrollment and implement real-time tissue collection to enhance success of collecting tumor samples and data. |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
unknown |
| Relation: |
qt3d30b424; https://escholarship.org/uc/item/3d30b424; https://escholarship.org/content/qt3d30b424/qt3d30b424.pdf |
| DOI: |
10.1017/s204017441700006x |
| Availability: |
https://escholarship.org/uc/item/3d30b424; https://escholarship.org/content/qt3d30b424/qt3d30b424.pdf; https://doi.org/10.1017/s204017441700006x |
| Rights: |
public |
| Accession Number: |
edsbas.B0B450E |
| Database: |
BASE |