| Title: |
Update regarding the role of PD-L1 in oncocytic thyroid lesions on cytological samples |
| Authors: |
Dell'Aquila, Marco; Tralongo, Pietro; Granitto, Alessia; Martini, Maurizio; Capodimonti, Sara; Curatolo, Mariangela; Fiorentino, Vincenzo; Pontecorvi, Alfredo; Fadda, Guido; Lombardi, Celestino Pio; Raffaelli, Maco; Pantanowitz, Liron; Larocca, Luigi Maria; Rossi, Esther Diana |
| Contributors: |
Dell'Aquila, Marco; Tralongo, Pietro; Granitto, Alessia; Martini, Maurizio; Capodimonti, Sara; Curatolo, Mariangela; Fiorentino, Vincenzo; Pontecorvi, Alfredo; Fadda, Guido; Lombardi, Celestino Pio; Raffaelli, Maco; Pantanowitz, Liron; Larocca, Luigi Maria; Rossi, Esther Diana |
| Publisher Information: |
BMJ PUBLISHING GROUP |
| Publication Year: |
2023 |
| Collection: |
Università degli Studi di Messina: IRIS |
| Subject Terms: |
Thyroid Diseases,Thyroid Gland; Thyroid Neoplasms |
| Description: |
Aims Several papers have shown that programmed death-ligand 1 (PD-L1) expression is a relevant predictive biomarker in anti-PD-L1 cancer immunotherapy. While its role in several human cancers is correlated with poor prognosis and resistance to anticancer therapies, in thyroid cancers the role of PD-L1 remains questionable. Few articles have studied PD-L1 in thyroid fine-needle aspiration cytology (FNAC), demonstrating a possible correlation with papillary thyroid carcinoma. However, its role in oncocytic thyroid lesions remains controversial. We accordingly examine the performance of PD-L1 immunostaining in liquid based cytology (LBC) from oncocytic lesions. Methods From January 2019 to March 2021, 114 thyroid lesions diagnosed by FNAC from lesions with a predominant oncocytic component, were enrolled for evaluation by PD-L1 immunostaining on both LBC and corresponding histology samples. Results The FNAC cohort included 51 benign (B, negative controls), 4 atypia of undetermined significance/follicular lesions of undetermined significance (AUS/FLUS), 57 follicular lesions (follicular neoplasm/suspicious for FN, FN/SFN) and 2 suspicious for malignancy (SFM) cases. Fifty-four cases (11B, 2 AUS/FLUS, 39 FN/SFN and 2 SFM) had histological follow-up including: 1B case resulted as a hyperplastic oxyphilic nodule in Hashimoto thyroiditis (HT), 10B as goitre, 2 AUS/FLUS cases as oncocytic adenomas (OAs); 39 FN/SFN included 27 OAs, 4 FA and 8 oncocytic follicular carcinoma (OFC). The two SFM cases were diagnosed on histopathology as OAs. Increased plasma membrane and cytoplasmic PD-L1 expression were found in 47 cases of the LBC cases (41.2%). Among the histological series, 67.3% of OAs and 75% of OFC had PD-L1 expression, while negative PD-L1 was found in hyperplastic oncocytic cells in HT. A positivity in more than 30% of the neoplastic cells was found in 72.9% of the cases including six OFC. Conclusions These data suggest that PD-L1 expression is expressed in oncocytic thyroid lesions. While weak PD-L1 expression ... |
| Document Type: |
article in journal/newspaper |
| File Description: |
STAMPA |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/35701142; info:eu-repo/semantics/altIdentifier/wos/WOS:000811710500001; volume:76; issue:10; firstpage:671; lastpage:677; numberofpages:7; journal:JOURNAL OF CLINICAL PATHOLOGY; https://hdl.handle.net/11570/3254182; https://jcp.bmj.com/content/76/10/671.long |
| DOI: |
10.1136/jclinpath-2022-208215 |
| Availability: |
https://hdl.handle.net/11570/3254182; https://doi.org/10.1136/jclinpath-2022-208215; https://jcp.bmj.com/content/76/10/671.long |
| Rights: |
info:eu-repo/semantics/openAccess |
| Accession Number: |
edsbas.B0C70CA4 |
| Database: |
BASE |