| Title: |
High vaccination coverage and infection rate result in a robust SARS‐CoV‐2‐specific immunity in the majority of liver cirrhosis and transplant patients: A single‐center cross‐sectional study |
| Authors: |
von der Schulenburg, P.; Herting, A.; Harberts, A.; Lütgehetmann, M.; Jahnke‐Triankowski, J.; Pischke, S.; Piecha, F.; Drolz, A.; Jörg, V.; Hübener, P.; Wehmeyer, M.; Addo, M. M.; Fischer, L.; Lohse, A. W.; Schulze Zur Wiesch, J.; Sterneck, M. |
| Source: |
United European Gastroenterology Journal ; volume 12, issue 3, page 339-351 ; ISSN 2050-6406 2050-6414 |
| Publisher Information: |
Wiley |
| Publication Year: |
2024 |
| Collection: |
Wiley Online Library (Open Access Articles via Crossref) |
| Description: |
Background In the third year of the SARS‐CoV‐2 pandemic, little is known about the vaccine‐ and infection‐induced immune response in liver transplant recipients (LTR) and liver cirrhosis patients (LCP). Objective This cross‐sectional study assessed the vaccination coverage, infection rate, and the resulting humoral and cellular SARS‐CoV‐2‐specific immune responses in a cohort of LTR and LCP at the University Medical Center Hamburg‐Eppendorf, Germany between March and May 2023. Methods Clinical and laboratory data from 244 consecutive patients (160 LTR and 84 LCP) were collected via chart review and a patient survey. Immune responses were determined via standard spike(S)‐ and nucleocapsid‐protein serology and a spike‐specific Interferon‐gamma release assay (IGRA). Results On average, LTR and LCP were vaccinated 3.7 and 3.3 times, respectively and 59.4% of patients received ≥4 vaccinations. Altogether, 68.1% (109/160) of LTR and 70.2% (59/84) of LCP experienced a SARS‐CoV‐2 infection. Most infections occurred during the Omicron wave in 2022 after an average of 3.0 vaccinations. Overall, the hospitalization rate was low ( |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1002/ueg2.12528 |
| Availability: |
http://dx.doi.org/10.1002/ueg2.12528; https://onlinelibrary.wiley.com/doi/pdf/10.1002/ueg2.12528 |
| Rights: |
http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Accession Number: |
edsbas.B0E246AF |
| Database: |
BASE |