| Title: |
Toward Male Individualization with Rapidly Mutating Y-Chromosomal Short Tandem Repeats |
| Authors: |
Ballantyne, K.N.; Ralf, A.; Aboukhalid, R.; Achakzai, N.M.; Anjos, M.J.; Ayub, Q.; Balazic, J.; Ballantyne, J.; Ballard, D.J.; Berger, B.; Bobillo, C.; Bouabdellah, M.; Burri, H.; Capal, T.; Caratti, S.; Cardenas, J.; Cartault, F.; Carvalho, E.F.; Carvalho, M.; Cheng, B.; Coble, M.D.; Comas, D.; Corach, D.; D'Amato, M.E.; Davison, S.; de Knijff, P.; De Ungria, M.C.A.; Decorte, R.; Dobosz, T.; Dupuy, B.M.; Elmrghni, S.; Gliwinski, M.; Gomes, S.C.; Grol, L.; Haas, C.; Hanson, E.; Henke, J.; Henke, L.; Herrera-Rodriguez, F.; Hill, C.R.; Holmlund, G.; Honda, K.; Immel, U.-D.; Inokuchi, S.; Jobling, M.A.; Kaddura, M.; Kim, J.S.; Kim, S.H.; Kim, W.; King, T.E.; Klausriegler, E.; Kling, D.; Kovacevic, L.; Kovatsi, L.; Krajewski, P.; Kravchenko, S.; Larmuseau, M.H.D.; Lee, E.Y.; Lessig, R.; Livshits, L.A.; Marjanovic, D.; Minarik, M.; Mizuno, N.; Moreira, H.; Morling, N.; Mukherjee, M.; Munier, P.; Nagaraju, J.; Neuhuber, F.; Nie, S.; Nilasitsataporn, P.; Nishi, T.; Oh, H.H.; Olofsson, J.; Onofri, V.; Palo, J.U.; Pamjav, H.; Parson, W.; Petlach, M.; Phillips, C.; Ploski, R.; Prasad, S.P.R.; Primorac, D.; Purnomo, G.A.; Purps, J.; Rangel-Villalobos, H.; Rebala, K.; Rerkamnuaychoke, B.; Rey Gonzalez, D.; Robino, C.; Roewer, L.; Rosa, A.; Sajantila, A.; Sala, A.; Salvador, J.M.; Sanz, P.; Schmitt, C.; Sharma, A.K.; Silva, D.A.; Shin, K.-J.; Sijen, T.; Sirker, M.; Sivakova, D.; Skaro, V.; Solano-Matamoros, C.; Souto, L.; Stenzl, V.; Sudoyo, H.; Syndercombe-Court, D.; Tagliabracci, A.; Taylor, D.; Tillmar, A.; Tsybovsky, I.S.; Tyler-Smith, C.; van der Gaag, K.J.; Vanek, D.; Volgyi, A.; Ward, D.; Willemse, P.; Yap, E.P.H.; Yong, R.Y.Y.; Pajnic, I.Z.; Kayser, M. |
| Publisher Information: |
Wiley |
| Publication Year: |
2014 |
| Collection: |
White Rose Research Online (Universities of Leeds, Sheffield & York) |
| Description: |
Relevant for various areas of human genetics, Y-chromosomal short tandem repeats (Y-STRs) are commonly used for testing close paternal relationships among individuals and populations, and for male lineage identification. However, even the widely used 17-loci Yfiler set cannot resolve individuals and populations completely. Here, 52 centers generated quality-controlled data of 13 rapidly mutating (RM) Y-STRs in 14,644 related and unrelated males from 111 worldwide populations. Strikingly, >99% of the 12,272 unrelated males were completely individualized. Haplotype diversity was extremely high (global: 0.9999985, regional: 0.99836–0.9999988). Haplotype sharing between populations was almost absent except for six (0.05%) of the 12,156 haplotypes. Haplotype sharing within populations was generally rare (0.8% nonunique haplotypes), significantly lower in urban (0.9%) than rural (2.1%) and highest in endogamous groups (14.3%). Analysis of molecular variance revealed 99.98% of variation within populations, 0.018% among populations within groups, and 0.002% among groups. Of the 2,372 newly and 156 previously typed male relative pairs, 29% were differentiated including 27% of the 2,378 father–son pairs. Relative to Yfiler, haplotype diversity was increased in 86% of the populations tested and overall male relative differentiation was raised by 23.5%. Our study demonstrates the value of RM Y-STRs in identifying and separating unrelated and related males and provides a reference database. |
| Document Type: |
article in journal/newspaper |
| File Description: |
text |
| Language: |
English |
| ISSN: |
1059-7794 |
| Relation: |
https://eprints.whiterose.ac.uk/id/eprint/108164/1/Toward%20male%20individualization%20with%20rapidly%20mutating%20y-chromosomal%20short%20tandem%20repeats.pdf; Ballantyne, K.N., Ralf, A., Aboukhalid, R. et al. (120 more authors) (2014) Toward Male Individualization with Rapidly Mutating Y-Chromosomal Short Tandem Repeats. Human Mutation, 35 (8). pp. 1021-1032. ISSN: 1059-7794 |
| DOI: |
10.1002/humu.22599 |
| Availability: |
https://eprints.whiterose.ac.uk/id/eprint/108164/; https://doi.org/10.1002/humu.22599 |
| Rights: |
cc_by_3 |
| Accession Number: |
edsbas.B123B3AB |
| Database: |
BASE |