| Title: |
Withdrawal syndrome from gamma-hydroxybutyric acid (GHB) and 1,4-butanediol (1,4-BD) in Sardinian alcohol-preferring rats |
| Authors: |
Carai, MAM; Quang, LS; Atzeri, S; Lobina, C; Maccioni, P; Orru, A; Gessa, GL; Maher, TJ; Colombo, G |
| Source: |
Brain research protocols 15 (2005): 75–78. doi:10.1016/j.brainresprot.2005.04.001 ; info:cnr-pdr/source/autori:Carai, MAM; Quang, LS; Atzeri, S; Lobina, C; Maccioni, P; Orru, A; Gessa, GL; Maher, TJ; Colombo, G/titolo:Withdrawal syndrome from gamma-hydroxybutyric acid (GHB) and 1,4-butanediol (1,4-BD) in Sardinian alcohol-preferring rats/doi:10.1016j.brainresprot.2005.04.001/rivista:Brain research protocols/anno:2005/pagina_da:75/pagina_a:78/intervallo_pagine:75–78/volume:15 |
| Publisher Information: |
Elsevier, Shannon , Paesi Bassi |
| Publication Year: |
2005 |
| Collection: |
PUMAlab (ISTI CNR - Consiglio Nazionale delle Ricerche / National Research Council) |
| Subject Terms: |
gamma-hydroxybutyric acid (GHB); 4-butanediol (1; 4-BD); withdrawal syndrome; Sardinian alcohol-preferring (sP) rats |
| Time: |
1 |
| Description: |
gamma-hydroxybutyric acid (GHB) and its precursors, 1,4-butanediol (1,4-BD) and gamma-butyrolactone (GBL), are recreational drugs widely abused in the US, Europe and Australasia. A severe withdrawal syndrome from GHB, 1,4-BD and GBL has been increasingly documented over the last years, necessitating the development of a reliable animal model for investigations of potential therapeutic approaches. The present study describes the induction and occurrence of audiogenic seizures as a sign of withdrawal from GHB and 1,4-BD in selectively bred Sardinian alcohol-preferring (sP) rats, treated with escalating doses of GHB (1.5-3.5 g/kg, twice daily; i.g.) or 1,4-BD (500-1000 mg/kg, twice daily; i.g.) for 9 consecutive days. Acute administration of the selective GABA(B) receptor antagonist, SCH 50911, dramatically increased seizure occurrence. We propose that the inherent sensitivity of sP rats to different GHB-associated responses may have contributed to the unraveling of a phenomenon which was otherwise not recognizable in other rat strains. (C) 2005 Elsevier B.V. All rights reserved. |
| Document Type: |
article in journal/newspaper |
| Language: |
unknown |
| Relation: |
info:cnr-pdr/author/matricola:14782/MACCIONI/PAOLA; http://www.cnr.it/prodotto/i/308541; https://publications.cnr.it/doc/308541; https://dx.doi.org/10.1016/j.brainresprot.2005.04.001; info:doi:10.1016/j.brainresprot.2005.04.001 |
| DOI: |
10.1016/j.brainresprot.2005.04.001 |
| Availability: |
http://www.cnr.it/prodotto/i/308541; https://publications.cnr.it/doc/308541; https://doi.org/10.1016/j.brainresprot.2005.04.001 |
| Accession Number: |
edsbas.B18EBF8B |
| Database: |
BASE |