| Title: |
Cardiopulmonary Fitness and Physical Activity Among Children and Adolescents With Inherited Cardiac Disease |
| Authors: |
Souilla, Luc; Werner, Oscar; Huguet, Helena; Gavotto, Arthur; Vincenti, Marie; Pasquié, Jean Luc; de la Villeon, Gregoire; Guillaumont, Sophie; Pommier, Victor; Matecki, Stefan; Baruteau, Alban-Elouen; Beyler, Constance; Delclaux, Christophe; Denjoy, Isabelle; Charron, Philippe; Chevalier, Philippe; Delinière, Antoine; Andrianoely, Mathieu; Cornuault, Lauriane; Besnard-Neyraud, Caroline; Sacher, Frederic; Reant, Patricia; Mottet, Denis; Picot, Marie-Christine; Amedro, Pascal; Abassi, Hamouda; Boisson, Aymeric; Requirand, Anne; Auer, Annie; Probst, Vincent; Prigent, Solène; Hauet, Quentin; Haddad, Christelle; Bertail-Galoin, Claire; Iriart, Xavier; Thomas-Chabaneix, Julie; Duboue, Pierre-Marie; Ruissel, Amandine; Selly, Jean-Bernard |
| Contributors: |
Physiologie & médecine expérimentale du Cœur et des Muscles U 1046 (PhyMedExp); Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM); Université de Montpellier (UM); Centre Hospitalier Régional Universitaire Montpellier (CHRU Montpellier); Centre d’Investigation Clinique de Nantes (CIC Nantes); Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Universitaire de Nantes = Nantes University Hospital (CHU Nantes); Physiopathologie des Adaptations Nutritionnelles (PhAN); Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Nantes Université - UFR de Médecine et des Techniques Médicales (Nantes Univ - UFR MEDECINE); Nantes Université - pôle Santé; Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - pôle Santé; Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ); Mécanismes en sciences intégratives du vivant (MeLiS); Université Claude Bernard Lyon 1 (UCBL); Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS); IHU-LIRYC; Université Bordeaux Segalen - Bordeaux 2-Centre Hospitalier Universitaire de Bordeaux (CHU Bordeaux); Centre de recherche Cardio-Thoracique de Bordeaux Bordeaux (CRCTB); Université de Bordeaux (UB)-Centre Hospitalier Universitaire de Bordeaux (CHU Bordeaux)-Institut National de la Santé et de la Recherche Médicale (INSERM); EuroMov - Digital Health in Motion (Euromov DHM); IMT MINES ALÈS; Institut Mines-Télécom Paris (IMT)-Institut Mines-Télécom Paris (IMT)-Université de Montpellier (UM) |
| Source: |
EISSN: 2574-3805 ; JAMA Network Open ; https://hal.science/hal-04966817 ; JAMA Network Open, 2025, 8 (2), pp.e2461795. ⟨10.1001/jamanetworkopen.2024.61795⟩ |
| Publisher Information: |
CCSD; American Medical Association |
| Publication Year: |
2025 |
| Collection: |
Université de Nantes: HAL-UNIV-NANTES |
| Subject Terms: |
[SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system; [SDV.MHEP.PED]Life Sciences [q-bio]/Human health and pathology/Pediatrics; [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie |
| Description: |
International audience ; Importance: Historical restrictions on children with inherited cardiac arrhythmia or cardiomyopathy have been implemented to mitigate the potential risk of sudden death, but these limitations can be detrimental to overall health and cardiopulmonary fitness.Objectives: To evaluate cardiopulmonary fitness and physical activity among children with inherited cardiac disease and identify the factors associated with maximum oxygen uptake (V̇o2max) in this population.Design, Setting, and Participants: This cross-sectional, multicenter, prospective controlled study was conducted in 7 tertiary care expert centers for inherited cardiac disease in France from February 1, 2021, to June 20, 2023, with a 2-week follow-up. Participants included 100 children and adolescents aged 6 to 17 years with inherited cardiac arrhythmia or cardiomyopathy who were compared with 107 sex- and age-matched controls.Main Outcomes and Measures: Maximum oxygen uptake was assessed using cardiopulmonary exercise testing, and results were expressed using pediatric reference z score values. The main determinants of V̇o2max included clinical (New York Heart Association [NYHA] functional class, treatment, echocardiographic, and electrocardiogram variables), functional (cardiopulmonary exercise test parameters), sociodemographic (sex, schooling, and parents’ education), and behavioral (physical activity and motivation) characteristics.Results A total of 100 patients (mean [SD] age, 12.7 [3.1] years; 52 boys [52.0%]) and 107 controls (mean [SD] age, 11.7 [3.3] years; 54 boys [50.5%]) were included. The V̇o2max was lower in patients than controls, expressed as z scores (mean [SD] score, −1.49 [1.48] vs −0.16 [0.97]; P < .001) or raw values (mean [SD] value, 32.2 [7.9] vs 40.2 [8.5] mL/kg/min; P < .001). Moderate to vigorous physical activity levels were lower in patients than in controls (mean [SD] level, 42.0 [23.6] vs 48.2 [20.4] min/d; P = .009). The final multivariable model explained 80% of the V̇o2max by integrating ... |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| ISBN: |
978-0-01-434690-5; 0-01-434690-7 |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/39998828; PUBMED: 39998828; WOS: 001434690700008 |
| DOI: |
10.1001/jamanetworkopen.2024.61795 |
| Availability: |
https://hal.science/hal-04966817; https://hal.science/hal-04966817v1/document; https://hal.science/hal-04966817v1/file/2025%20Souilla%20et%20al.,%20Cardiopulmonary%20Fitness%20and%20Physical.pdf; https://doi.org/10.1001/jamanetworkopen.2024.61795 |
| Rights: |
https://about.hal.science/hal-authorisation-v1/ ; info:eu-repo/semantics/OpenAccess |
| Accession Number: |
edsbas.B19448E |
| Database: |
BASE |