| Title: |
Long-term outcomes and temporal trends following liver transplantation for chronic liver disease in intensive care unit. |
| Authors: |
Meszaros, Magdalena; Ursic-Bedoya, José; Coilly, Audrey; Francoz, Claire; Duvoux, Cristophe.; Conti, Filomena; Faitot, François; Houssel‐debry, Pauline; Hardwigsen, Jean; Hilleret, Marie-Noelle; Vanlemmens, Claire; Elkrief, Laure; Kamar, Nassim; Anty, Rodolphe; Abergel, Armand; Perignon, Claire; Chiche, Laurence; Debette-Gratien, Maryline; Antonini, Teresa; Antoine, Corinne; Dharancy, Sébastien; Dumortier, Jérôme; Pageaux, Georges-Philippe; Artru, Florent |
| Contributors: |
Hôpital Saint Eloi CHU Montpellier; Centre Hospitalier Régional Universitaire Montpellier (CHRU Montpellier); Université de Montpellier (UM); Hôpital Paul Brousse; AP-HP. Université Paris Saclay; Hôpital Beaujon AP-HP; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP); Hôpital Henri Mondor; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Henri Mondor Créteil; Groupe Henri Mondor-Albert Chenevier-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Groupe Henri Mondor-Albert Chenevier-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12); Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12); CHU Pitié-Salpêtrière AP-HP; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU); Université de Strasbourg (UNISTRA); Centre Hospitalier Universitaire de Rennes CHU Rennes = Rennes University Hospital Pontchaillou; Nutrition, Métabolismes et Cancer (NuMeCan); Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE); Hôpital de la Timone CHU - APHM (TIMONE); Institute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble) (IAB); Établissement Français du Sang Auvergne-Rhône-Alpes Lyon (EFS Auvergne-Rhône-Alpes - Lyon); Établissement Français du Sang La Plaine Saint-Denis (EFS)-Établissement Français du Sang La Plaine Saint-Denis (EFS)-CHU de Grenoble-Alpes - Centre Hospitalier Universitaire CHU Grenoble (CHUGA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA); CHU de Grenoble-Alpes - Centre Hospitalier Universitaire CHU Grenoble (CHUGA); Université de Franche-Comté (UFC); Université Bourgogne Franche-Comté COMUE (UBFC); Hôpital Jean Minjoz Besançon; Centre Hospitalier Régional Universitaire de Tours (CHRU Tours); Institut Toulousain des Maladies Infectieuses et Inflammatoires (Infinity); Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Toulouse (EPE UT); Communauté d'universités et établissements de Toulouse (Comue de Toulouse)-Communauté d'universités et établissements de Toulouse (Comue de Toulouse); Centre Hospitalier Universitaire de Toulouse (CHU Toulouse); Hôpital l'Archet; Centre Hospitalier Universitaire de Nice (CHU Nice); CHU Estaing Clermont-Ferrand; CHU Clermont-Ferrand; Hôpital Côte de Nacre CHU Caen; CHU Caen Normandie – Centre Hospitalier Universitaire de Caen Normandie (CHU Caen Normandie); Normandie Université (NU)-Normandie Université (NU); Hôpital Haut-Lévêque CHU Bordeaux; Centre Hospitalier Universitaire de Bordeaux (CHU Bordeaux); CHU Limoges; Hôpital de la Croix-Rousse CHU - HCL; Hospices Civils de Lyon (HCL); Agence de la biomédecine Saint-Denis la Plaine; Hôpital Claude Huriez Lille; Centre Hospitalier Régional Universitaire CHU Lille (CHRU Lille); Hôpital Edouard Herriot CHU - HCL |
| Source: |
EISSN: 2589-5559 ; JHEP Reports Innovation in Hepatology ; https://hal.science/hal-05503217 ; JHEP Reports Innovation in Hepatology, 2026, 8 (4), pp.101722. ⟨10.1016/j.jhepr.2025.101722⟩ |
| Publisher Information: |
CCSD; Elsevier |
| Publication Year: |
2026 |
| Collection: |
Université Toulouse III - Paul Sabatier: HAL-UPS |
| Subject Terms: |
liver transplantation; intensive care unit; long-term mortality; [SDV.MHEP.HEG]Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology; [SDV.MHEP.CHI]Life Sciences [q-bio]/Human health and pathology/Surgery; [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie |
| Description: |
International audience ; Background and Aims: Liver transplantation (LT) remains the definitive treatment for patients with end-stage chronic liver disease (CLD). However, those transplanted while in intensive care unit (ICU) represent a high-risk population. Large-scale data on long-term prognosis in this group are limited. We aimed to assess long-term outcomes in CLD patients undergoing LT from the ICU and to compare outcomes over time.Methods: This retrospective cohort study used the French national transplant registry (CRISTAL). Adults with CLD who underwent LT from the ICU between 2008 and 2018 were included. Organ failures were defined according to EASL CLIF-OF criteria. Five-year survival and associated risk factors were analyzed and compared across four time periods (2008–2010, 2011–2013, 2014–2016, 2017–2018).Results: Among 13,372 LTs performed in France during the study period, 9,686 were for CLD, of whom 1,287 (13.2%) were in the ICU at the time of LT. Alcohol-related liver disease (50%) and viral hepatitis (16.1%) were the leading etiologies. Five-year survival was significantly lower in CLD-ICU patients compared to non-ICU patients (69.2% vs. 79.1%, p |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/41810429; PUBMED: 41810429; PUBMEDCENTRAL: PMC12969417 |
| DOI: |
10.1016/j.jhepr.2025.101722 |
| Availability: |
https://hal.science/hal-05503217; https://hal.science/hal-05503217v1/document; https://hal.science/hal-05503217v1/file/1-s2.0-S2589555925004057-main.pdf; https://doi.org/10.1016/j.jhepr.2025.101722 |
| Rights: |
https://creativecommons.org/licenses/by/4.0/ ; info:eu-repo/semantics/OpenAccess |
| Accession Number: |
edsbas.B1D15110 |
| Database: |
BASE |