| Title: |
A cost‐effective and reliable method to predict mechanical stress in single‐use and standard pumps |
| Authors: |
Dittler, Ina; Kaiser, Stephan C.; Blaschczok, Katharina; Löffelholz, Christian; Bösch, Pascal; Dornfeld, Wolfgang; Schöb, Reto; Rojahn, Jürgen; Kraume, Matthias; Eibl, Dieter |
| Source: |
Engineering in Life Sciences ; volume 14, issue 3, page 311-317 ; ISSN 1618-0240 1618-2863 |
| Publisher Information: |
Wiley |
| Publication Year: |
2014 |
| Collection: |
Wiley Online Library (Open Access Articles via Crossref) |
| Description: |
The suitability of oil–water emulsions to predict shear forces in stirred bioreactors under cost‐effective and time‐saving conditions has been demonstrated several times, but no application to pumps has been described so far. In this report, the drop sizes in a model oil–water system were determined for the Levitronix PuraLev® multiuse (MU) series (PuraLev® 200MU and PuraLev® 600MU), a peristaltic pump (Masterflex® I/P Easy Load), and 4‐piston diaphragm pump (Quattroflow 1200‐SU, where SU is single‐use) using inline endoscopy. It was determined that the Sauter mean diameter could be used as a comparison criterion to estimate mechanical stress in pumps. The investigation showed that PuraLev® MU pumps are characterized by up to 59% larger Sauter mean diameters than their counterparts at comparable operational conditions. This indicates lower hydrodynamic stress in the PuraLev® MU pumps. Using computational fluid dynamics, a well‐streamlined fluid flow and low turbulent energy dissipation rates were found in the PuraLev® MU pumps, which correlated well with experimental results. A calculation model was used to predict the Sauter mean diameter by combining both experimental and computational fluid dynamics data. Good agreement with deviations below 13% was determined between model predictions and experimental data. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1002/elsc.201300068 |
| Availability: |
https://doi.org/10.1002/elsc.201300068; https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Felsc.201300068; https://onlinelibrary.wiley.com/doi/pdf/10.1002/elsc.201300068 |
| Rights: |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
| Accession Number: |
edsbas.B1EE5429 |
| Database: |
BASE |