| Title: |
A phase II study: dose-dense carboplatin and paclitaxel as neoadjuvant chemotherapy in locally advanced cervical cancer |
| Authors: |
Loizzi, Vera; Del Vecchio, Vittoria; Crupano, Francesco M; Minicucci, Valentina; Fumarulo, Valeria V; Resta, Leonardo; Vimercati, Antonella; Bettocchi, Stefano; Cicinelli, Ettore; Cormio, Gennaro |
| Contributors: |
Loizzi, Vera; Del Vecchio, Vittoria; Crupano, Francesco M; Minicucci, Valentina; Fumarulo, Valeria V; Resta, Leonardo; Vimercati, Antonella; Bettocchi, Stefano; Cicinelli, Ettore; Cormio, Gennaro |
| Publication Year: |
2018 |
| Collection: |
Università degli Studi di Foggia: CINECA IRIS Institutional Research Information System |
| Subject Terms: |
Cervical cancer; Chemotherapy; Neoadjuvant; Toxicity |
| Description: |
This study evaluates the efficacy and toxicity of dose-dense weekly paclitaxel and carboplatin as neoadjuvant chemotherapy in locally advanced cervical cancer (LACC). We collected 23 cases of LACC treated with weekly paclitaxel and carboplatin for nine cycles: 20 patients had complete or partial response to chemotherapy and were submitted to surgery, 3 with poor response received chemoradiation therapy. Pathologic examination showed complete response in four patients, myometrial invasion 50% in seven patients, parametrial involvement in two, vaginal metastasis in one and lymphovascular space invasion, with positive margins, in another case. Despite seven patients had radiological evidence of lymph nodes involvement at diagnosis, only one had nodal metastases. Five patients showed grade 3-4 of hematologic toxicity. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/30375951; info:eu-repo/semantics/altIdentifier/wos/WOS:000450166600007; volume:30; issue:4; firstpage:247; lastpage:252; numberofpages:6; journal:JOURNAL OF CHEMOTHERAPY; https://hdl.handle.net/11369/409362 |
| DOI: |
10.1080/1120009X.2018.1489601 |
| Availability: |
https://hdl.handle.net/11369/409362; https://doi.org/10.1080/1120009X.2018.1489601 |
| Accession Number: |
edsbas.B2622F3E |
| Database: |
BASE |