| Title: |
The Key Role of Warm and Cold Ischemia in Uterus Transplantation: A Review |
| Authors: |
Tardieu, Antoine; Dion, Ludivine; Lavoue, Vincent; Chazelas, Pauline; Marquet, Pierre; Piver, Pascal; Sallee, Camille; Aubard, Yves; Barin-Le Guellec, Chantal; Favreau, Frederic; Gauthier, Tristan |
| Contributors: |
Ciblage individuel et prévention des risques de traitements immunosupresseurs et de la transplantation (IPPRITT); CHU Limoges-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST); Université de Limoges (UNILIM)-Université de Limoges (UNILIM); CHU Limoges; Centre Hospitalier Universitaire de Rennes CHU Rennes = Rennes University Hospital Pontchaillou; Chemistry, Oncogenesis, Stress and Signaling (COSS); Université de Rennes (UR)-CRLCC Eugène Marquis (CRLCC); UNICANCER-UNICANCER-Institut National de la Santé et de la Recherche Médicale (INSERM); Maintenance Myélinique et Neuropathies Périphériques (MMNP); Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST); Service de Gynécologie-Obstétrique CHU Limoges; Université de Tours (UT); French Agency for Biomedicine |
| Source: |
ISSN: 2077-0383 ; Journal of Clinical Medicine ; https://univ-rennes.hal.science/hal-02278514 ; Journal of Clinical Medicine, 2019, 8 (6), pp.E760. ⟨10.3390/jcm8060760⟩. |
| Publisher Information: |
CCSD; MDPI |
| Publication Year: |
2019 |
| Collection: |
Université François-Rabelais de Tours: HAL |
| Subject Terms: |
transplantation; ischemia; uterus; deceased donor; [SDV.MHEP.GEO]Life Sciences [q-bio]/Human health and pathology/Gynecology and obstetrics; [SDV.MHEP.CHI]Life Sciences [q-bio]/Human health and pathology/Surgery |
| Description: |
International audience ; Introduction: Uterus transplantation (UTx) is a promising treatment for uterine infertility that has resulted in several births since 2014. Ischemia is a key step in organ transplantation because it may lead to changes jeopardizing graft viability.Method: We performed a systematic review of animal and human studies relating to uterine ischemia.Results: We retained 64 studies published since 2000. There were 35 studies in animals, 24 in humans, and five literature reviews. Modest preliminary results in large animals and humans are limited but encouraging. In small animals, pregnancies have been reported to occur after 24 h of cold ischemia (CI). In ewes, uterine contractions have been detected after 24 h of CI. Furthermore, it has been shown in animals that uterine tolerance to CI and to warm ischemia (WI) can be increased by pharmacological products. In women, mean CI time in studies of births from uteri obtained from live donors was between 2 h 47 min and 6 h 20 min from a deceased donor; with only one birth in this case. Muscle contractions have also been demonstrated in myometrial samples from women, after six or more hours of CI.Conclusion: The uterus seems to be able to tolerate a prolonged period of CI, of at least six hours. Studies of the ischemia tolerance of the uterus and ways to improve it are essential for the development of UTx, particularly for procedures using grafts from deceased donors |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/31146406; PUBMED: 31146406 |
| DOI: |
10.3390/jcm8060760 |
| Availability: |
https://univ-rennes.hal.science/hal-02278514; https://univ-rennes.hal.science/hal-02278514v1/document; https://univ-rennes.hal.science/hal-02278514v1/file/jcm-08-00760.pdf; https://doi.org/10.3390/jcm8060760 |
| Rights: |
https://about.hal.science/hal-authorisation-v1/ ; info:eu-repo/semantics/OpenAccess |
| Accession Number: |
edsbas.B26BA939 |
| Database: |
BASE |