| Contributors: |
McDonald, Emily; Mathis, Sarabeth; Martin, Stacey W.; Staples, J. Erin; Fischer, Marc; Lindsey, Nicole P.; National Center for Emerging and Zoonotic Infectious Diseases (U.S.); Div. of Vector-Borne Diseases; Centers for Disease Control and Prevention (U.S.); Epidemic Intelligence Service |
| Description: |
Problem/Condition ; West Nile Virus (WNV) is an arthropodborne Virus (arboVirus) in the family Flaviviridae and is the leading cause of domestically acquired arboviral disease in the contiguous U.S. An estimated 70%–80% of WNV infections are asymptomatic. Symptomatic persons usually develop an acute systemic febrile illness. Less than 1% of infected persons develop neuroinvasive disease, which typically presents as encephalitis, meningitis, or acute flaccid paralysis. ; Reporting Period ; 2009–2018. ; Description of System ; WNV disease is a nationally notifiable condition with standard Surveillance case definitions. State health departments report WNV cases to CDC through ArboNET, an electronic passive Surveillance system. Variables collected include patient age, sex, race, ethnicity, county and state of residence, date of illness onset, clinical syndrome, hospitalization, and death. ; Results ; During 2009–2018, a total of 21,869 confirmed or probable cases of WNV disease, including 12,835 (59%) WNV neuroinvasive disease cases, were reported to CDC from all 50 states, the District of Columbia, and Puerto Rico. A total of 89% of all WNV patients had illness onset during July–September. Neuroinvasive disease incidence and case-fatalities increased with increasing age, with the highest incidence (1.22 cases per 100,000 population) occurring among persons aged ≥70 years. Among neuroinvasive cases, hospitalization rates were >85% in all age groups but were highest among patients aged ≥70 years (98%). The national incidence of WNV neuroinvasive disease peaked in 2012 (0.92 cases per 100,000 population). Although national incidence was relatively stable during 2013–2018 (average annual incidence: 0.44; range: 0.40–0.51), state level incidence varied from year to year. During 2009–2018, the highest average annual incidence of neuroinvasive disease occurred in North Dakota (3.16 cases per 100,000 population), South Dakota (3.06), Nebraska (1.95), and Mississippi (1.17), and the largest number of total cases occurred ... |