| Title: |
Task activation results in regional 13 C-lactate signal increase in the human brain |
| Authors: |
Uthayakumar, Biranavan; Cappelletto, Nicole IC; Bragagnolo, Nadia D; Chen, Albert P; Ma, Nathan; Perks, William J; Endre, Ruby; Tam, Fred; Graham, Simon J; Heyn, Chris; Keshari, Kayvan R; Soliman, Hany; Cunningham, Charles H |
| Source: |
Journal of Cerebral Blood Flow & Metabolism ; volume 45, issue 7, page 1223-1231 ; ISSN 0271-678X 1559-7016 |
| Publisher Information: |
SAGE Publications |
| Publication Year: |
2025 |
| Description: |
Hyperpolarized- 13 C magnetic resonance imaging (HP- 13 C MRI) was used to image changes in 13 C-lactate signal during a visual stimulus condition in comparison to an eyes-closed control condition. Whole-brain 13 C-pyruvate, 13 C-lactate and 13 C-bicarbonate production was imaged in healthy volunteers (N = 6, ages 24–33) for the two conditions using two separate hyperpolarized 13 C-pyruvate injections. BOLD-fMRI scans were used to delineate regions of functional activation. 13 C-metabolite signal was normalized by 13 C-metabolite signal from the brainstem and the percentage change in 13 C-metabolite signal conditions was calculated. A one-way Wilcoxon signed-rank test showed a significant increase in 13 C-lactate in regions of activation when compared to the remainder of the brain ( p = 0.02 ). No significant increase was observed in 13 C-pyruvate signal ( p = 0.11 ) or 13 C-bicarbonate signal ( p = 0.95 ). The results show an increase in 13 C-lactate production in activated regions that is measurable with HP- 13 C MRI. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1177/0271678x251314683 |
| DOI: |
10.1177/0271678X251314683 |
| Availability: |
https://doi.org/10.1177/0271678x251314683; https://journals.sagepub.com/doi/pdf/10.1177/0271678X251314683; https://journals.sagepub.com/doi/full-xml/10.1177/0271678X251314683 |
| Rights: |
https://creativecommons.org/licenses/by-nc/4.0/ ; https://journals.sagepub.com/page/policies/text-and-data-mining-license |
| Accession Number: |
edsbas.B2A5622A |
| Database: |
BASE |