| Title: |
Memory Alterations and White Matter Hyperintensities in Elderly Patients With Hypertension: The ADELAHYDE-2 Study |
| Authors: |
Ferreira, João Pedro; Kearney Schwartz, Anna; Watfa, Ghassan; Lamiral, Zohra; Felblinger, Jacques; Boivin, Jean-Marc; Bracard, Serge; Hossu, Gabriella; Verger, Antoine; Joly, Laure; Zannad, Faiez; Rossignol, Patrick; Benetos, Athanase |
| Contributors: |
Défaillance Cardiovasculaire Aiguë et Chronique (DCAC); Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL); Centre d'investigation clinique plurithématique Pierre Drouin Nancy (CIC-P); Centre d'investigation clinique Nancy (CIC); Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL)-Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL); Cardiovascular and Renal Clinical Trialists Vandoeuvre-les-Nancy (INI-CRCT); Institut Lorrain du Coeur et des Vaisseaux Louis Mathieu Nancy; French-Clinical Research Infrastructure Network - F-CRIN Paris (Cardiovascular & Renal Clinical Trialists - CRCT); Universidade do Porto = University of Porto; Service de Gériatrie CHRU Nancy; Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy); Imagerie Adaptative Diagnostique et Interventionnelle (IADI); Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL); Département de neuroradiologie diagnostique et thérapeutique CHRU Nancy; Service de Médecine Nucléaire CHRU Nancy; Nancyclotep- Experimental Imaging Platform = Plate-forme d'imagerie moléculaire; Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Université de Lorraine (UL) |
| Source: |
ISSN: 1525-8610 ; Journal of the American Medical Directors Association ; https://hal.univ-lorraine.fr/hal-03231190 ; Journal of the American Medical Directors Association, 2017, 18 (5), pp.451.e13-451.e25. ⟨10.1016/j.jamda.2017.01.008⟩. |
| Publisher Information: |
CCSD; Elsevier |
| Publication Year: |
2017 |
| Collection: |
Université de Lorraine: HAL |
| Subject Terms: |
Memory alterations; predictors and associations; risk factors; white matter hyperintensities; [INFO.INFO-IM]Computer Science [cs]/Medical Imaging; [SDV.IB.MN]Life Sciences [q-bio]/Bioengineering/Nuclear medicine; [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology |
| Description: |
International audience ; Objectives: The longitudinal ADELAHYDE-2 study aims to identify the factors associated with cognitive impairment/decline and white matter hyperintensities burden.Methods: Longitudinal single-center study comprising two visits separated by approximately 7 years. A total of 131 patients completed the two visits. The primary outcome was global memory composite scale, while the secondary outcome was white matter hyperintensities (WMH/Fazekas scale) load.Results: Global memory at visit 2 (V2) was largely influenced by age, smoking status, glycated hemoglobin, and history of stroke already present at visit 1 (V1). These variables accounted for ∼51% of the memory alterations at V2. WMH at V2 was likely influenced by age, left ventricular hypertrophy, diabetes mellitus, carotid intima-media thickness, and body mass index at V1. These findings accounted for ∼37% of the WMH changes at V2. Increase in pulse wave velocity from V1 to V2 showed a trend for association with memory deterioration (adjusted estimates = 0.06; P = .067), whereas smoking and increase in systolic blood pressure (trend) were associated with an increment in WMH (adjusted estimates = 0.49; P = .047 and adjusted estimates = 0.01; P = .08, respectively). On the other hand, angiotensin-converting enzyme inhibitor/angiotensin receptor blockers and statins (trend) were likely to be protective (adjusted estimates for angiotensin-converting enzyme inhibitor/angiotensin receptor blockers = -0.49; P = .049, and adjusted estimates for statins = -0.46; P = .055).Conclusions: Several readily identifiable factors are associated with memory deterioration and WMH, many of which are potentially modifiable. Interventions aimed to control these risk factors need to be tested prospectively in order to assess their cognitive protective value. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/28279605; PUBMED: 28279605 |
| DOI: |
10.1016/j.jamda.2017.01.008 |
| Availability: |
https://hal.univ-lorraine.fr/hal-03231190; https://doi.org/10.1016/j.jamda.2017.01.008 |
| Accession Number: |
edsbas.B2EB197D |
| Database: |
BASE |