| Title: |
T2 *-weighted oxygen-enhanced pulmonary MRI in COPD is linked to resting and exertional functional measurements |
| Authors: |
Elbehairy, Amany F; Naish, Josephine H; Baghertash, Hossein; Parker, Geoff JM; Miller, Christopher A; Vestbo, Jorgen; Horsley, Alex R |
| Source: |
BMJ Open Respiratory Research , 12 (1) , Article e002784. (2025) |
| Publisher Information: |
BMJ PUBLISHING GROUP |
| Publication Year: |
2025 |
| Collection: |
University College London: UCL Discovery |
| Subject Terms: |
Science & Technology; Life Sciences & Biomedicine; Respiratory System; Exercise; Imaging/CT MRI etc; Lung Physiology; COPD Pathology; POORLY COMMUNICATING FRACTION; VENTILATION HETEROGENEITY; SYMPTOMATIC PATIENTS; EXERCISE CAPACITY; CARBON-MONOXIDE; LUNG; SMOKERS; DYSPNEA; PERFORMANCE; MECHANISMS |
| Description: |
Background T 2 ∗-weighted oxygen-enhanced MRI (T 2 ∗-OE-MRI) may directly assess pulmonary ventilation using oxygen as an inhaled tracer gas. It has shown promise in healthy volunteers (HVs) and cystic fibrosis but has yet to be demonstrated in patients with chronic obstructive pulmonary disease (COPD). Research question To determine the feasibility and repeatability of T 2 ∗-OE-MRI in patients with COPD. To assess correlations between T 2 ∗-OE-MRI measurements of pulmonary ventilation, pulmonary function tests (PFTs) and measures of functional limitation. Study design and methods 13 patients with mild-to-severe COPD and 13 HVs underwent PFTs, lung clearance index (LCI) measurement, incremental exercise test (patients only) and two lung MRI scans at 3 T. For T 2 ∗-OE-MRI, participants were fitted with a non-rebreathing face mask and given 100% oxygen during image acquisition. Results Patients (age: 63 (55-72) years, forced expiratory volume in 1 s (FEV 1): 63 (36-79) %predicted, median (IQR)) had evidence of pulmonary gas trapping, small airway disease (SAD) and ventilation heterogeneity. During T 2 ∗-OE-MRI, the magnitude of the percentage difference between mean signal intensity at normoxia and hyperoxia (percent signal enhancement (PSE)) and the enhancing fraction (EF) were lower in patients versus HVs (2.77 (2.19-4.19) vs 5.34 (4.33-5.61) % and 0.74 (0.66-0.77) vs 0.89 (0.82-0.94), respectively, both p |
| Document Type: |
article in journal/newspaper |
| File Description: |
text |
| Language: |
English |
| Relation: |
https://discovery.ucl.ac.uk/id/eprint/10212996/1/e002784.full.pdf; https://discovery.ucl.ac.uk/id/eprint/10212996/ |
| Availability: |
https://discovery.ucl.ac.uk/id/eprint/10212996/1/e002784.full.pdf; https://discovery.ucl.ac.uk/id/eprint/10212996/ |
| Rights: |
open |
| Accession Number: |
edsbas.B30CD268 |
| Database: |
BASE |