| Title: |
Cognitive and Psychosocial Outcome in Children and Adolescents Treated for Extracranial Malignant Solid Tumors and Lymphomas in the RISK‐N Study |
| Authors: |
Câmara-Costa, Hugo; Barrault, Zoé; Longaud, Audrey; Kieffer, Virginie; Grill, Jacques; Chevignard, Mathilde; Gaspar, Nathalie; Minard-Colin, Véronique; Fresneau, Brice; Rigaud, Charlotte; Saidoun, Lila; Guerrini-Rousseau, Léa; Abbou, Samuel; Berlanga, Pablo; Pasqualini, Claudia; Bolle, Stephanie; Dellatolas, Georges; Dufour, Christelle |
| Contributors: |
Laboratoire d'Imagerie Biomédicale Paris (LIB); Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS); Service de Rééducation des pathologies neurologiques acquises de l'enfant Hôpitaux de Saint Maurice; Hôpitaux de Saint Maurice (HNSM); Département de cancérologie de l'enfant et de l'adolescent Gustave Roussy; Institut Gustave Roussy (IGR); Groupe de recherche clinique Handicap Moteur et Cognitif et Réadaptation (GRC 24 - HaMCRe); Sorbonne Université (SU); Direction de la recherche Gustave Roussy; Immunologie anti-tumorale et immunothérapie des cancers (ITIC (U1015)); Institut Gustave Roussy (IGR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay; Département de radiothérapie Gustave Roussy |
| Source: |
ISSN: 1545-5009. |
| Publisher Information: |
CCSD; Wiley |
| Publication Year: |
2026 |
| Subject Terms: |
intellectual quotient; neurocognitive outcome; psychosocial outcome; lymphomas; Pediatric extracranial solid tumors; [SDV.MHEP.PED]Life Sciences [q-bio]/Human health and pathology/Pediatrics; [SDV.CAN]Life Sciences [q-bio]/Cancer; [SDV.NEU.SC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive Sciences; [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie |
| Description: |
International audience ; Objective: Recent studies show evidence of cognitive and psychosocial impairments and reduced quality of life (QoL) in adult survivors of childhood extracranial solid tumors and lymphomas, but limited research has addressed these issues in pediatric populations.Study Design: The French RISK‐N prospective study (2014–2021) evaluated 278 survivors of extracranial solid tumors or lymphomas (47% female, mean age at diagnosis and assessment: 6.2 and 11.7 years). Patients with pre‐existing neurological conditions were excluded. Sociodemographic, disease‐related, and treatment data were collected. Cognitive performance was assessed using Wechsler Intelligence Scales for Children (WISC‐IV, WISC‐V). Psychosocial outcomes included parent and/or patient‐reported executive functions (Behavior Rating Inventory of Executive Function), behavior (Conner's Parent Rating Scale), QoL (Pediatric Quality of Life Inventory), fatigue (Multidimensional Fatigue Scale), and depression (Children's Depression Inventory). Information on schooling and educational/rehabilitative interventions was also recorded.Results: Diagnoses included lymphoma (25%), nephroblastoma (19%), neuroblastoma (19%), osteosarcoma (7%), other sarcomas (18%), and other tumors (12%). Mean Full Scale Intellectual Quotient [ M (SD) = 99.44(15.62)] was as expected in the general population [ M (SD) = 100(15)], but the WISC‐IV Perceptual Reasoning Index was slightly lower [ M (SD) = 95.4(15.0), |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1002/1545-5017.70073 |
| Availability: |
https://hal.science/hal-05497784; https://hal.science/hal-05497784v1/document; https://hal.science/hal-05497784v1/file/Main%20manuscript.R2.pdf; https://doi.org/10.1002/1545-5017.70073 |
| Rights: |
https://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.B32878B2 |
| Database: |
BASE |