| Title: |
The Health & Aging Brain among Latino Elders (HABLE) study methods and participant characteristics |
| Authors: |
O'Bryant, Sid E; Johnson, Leigh A; Barber, Robert C; Braskie, Meredith N; Christian, Bradley; Hall, James R; Hazra, Nalini; King, Kevin; Kothapalli, Deydeep; Large, Stephanie; Mason, David; Matsiyevskiy, Elizabeth; McColl, Roderick; Nandy, Rajesh; Palmer, Raymond; Petersen, Melissa; Philips, Nicole; Rissman, Robert A; Shi, Yonggang; Toga, Arthur W; Vintimilla, Raul; Vig, Rocky; Zhang, Fan; Yaffe, Kristine; Team, for the HABLE Study |
| Source: |
Alzheimer's & Dementia Diagnosis Assessment & Disease Monitoring, vol 13, iss 1 |
| Publisher Information: |
eScholarship, University of California |
| Publication Year: |
2021 |
| Collection: |
University of California: eScholarship |
| Subject Terms: |
32 Biomedical and Clinical Sciences (for-2020); 3202 Clinical Sciences (for-2020); 52 Psychology (for-2020); Biomedical Imaging (rcdc); Minority Health (rcdc); Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD) (rcdc); Clinical Research (rcdc); Health Disparities (rcdc); Neurosciences (rcdc); Behavioral and Social Science (rcdc); Acquired Cognitive Impairment (rcdc); Aging (rcdc); Neurodegenerative (rcdc); Dementia (rcdc); Prevention (rcdc); Brain Disorders (rcdc); Alzheimer's Disease (rcdc); Neurological (hrcs-hc); Alzheimer's disease; amyloid; biomarkers; diversity; Hispanic; Mexican American; mild cognitive impairment; neurodegeneration; HABLE Study Team; 0604 Genetics (for); 1109 Neurosciences (for); 3209 Neurosciences (for-2020) |
| Description: |
INTRODUCTION: Mexican Americans remain severely underrepresented in Alzheimer's disease (AD) research. The Health & Aging Brain among Latino Elders (HABLE) study was created to fill important gaps in the existing literature. METHODS: Community-dwelling Mexican Americans and non-Hispanic White adults and elders (age 50 and above) were recruited. All participants underwent comprehensive assessments including an interview, functional exam, clinical labs, informant interview, neuropsychological testing, and 3T magnetic resonance imaging (MRI) of the brain. Amyloid and tau positron emission tomography (PET) scans were added at visit 2. Blood samples were stored in the Biorepository. RESULTS: Data was examined from n=1705 participants. Significant group differences were found in medical, demographic, and sociocultural factors. Cerebral amyloid and neurodegeneration imaging markers were significantly different between Mexican Americans and non-Hispanic Whites. DISCUSSION: The current data provide strong support for continued investigations that examine the risk factors for and biomarkers of AD among diverse populations. |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
unknown |
| Relation: |
qt3mm4p5k9; https://escholarship.org/uc/item/3mm4p5k9; https://escholarship.org/content/qt3mm4p5k9/qt3mm4p5k9.pdf |
| DOI: |
10.1002/dad2.12202 |
| Availability: |
https://escholarship.org/uc/item/3mm4p5k9; https://escholarship.org/content/qt3mm4p5k9/qt3mm4p5k9.pdf; https://doi.org/10.1002/dad2.12202 |
| Rights: |
CC-BY-NC-ND |
| Accession Number: |
edsbas.B38DA019 |
| Database: |
BASE |