| Title: |
Pharmacogenomics study of thiazide diuretics and QT interval in multi-ethnic populations: The cohorts for heart and aging research in genomic epidemiology |
| Authors: |
Seyerle, AA; Sitlani, CM; Noordam, R; Gogarten, SM; Li, J; Li, X; Evans, DS; Sun, F; Laaksonen, MA; Isaacs, A; Kristiansson, K; Highland, HM; Stewart, JD; Harris, TB; Trompet, S; Bis, JC; Peloso, GM; Brody, JA; Broer, L; Busch, EL; Duan, Q; Stilp, AM; O'Donnell, CJ; Macfarlane, PW; Floyd, JS; Kors, JA; Lin, HJ; Li-Gao, R; Sofer, T; Méndez-Giráldez, R; Cummings, SR; Heckbert, SR; Hofman, A; Ford, I; Li, Y; Launer, LJ; Porthan, K; Newton-Cheh, C; Napier, MD; Kerr, KF; Reiner, AP; Rice, KM; Roach, J; Buckley, BM; Soliman, EZ; De Mutsert, R; Sotoodehnia, N; Uitterlinden, AG; North, KE; Lee, CR; Gudnason, V; Stürmer, T; Rosendaal, FR; Taylor, KD; Wiggins, KL; Wilson, JG; Chen, YD; Kaplan, RC; Wilhelmsen, K; Cupples, LA; Salomaa, V; Van Duijn, C; Jukema, JW; Liu, Y; Mook-Kanamori, DO; Lange, LA; Vasan, RS; Smith, AV; Stricker, BH; Laurie, CC; Rotter, JI; Whitsel, EA; Psaty, BM; Avery, CL |
| Source: |
urn:ISSN:1470-269X ; urn:ISSN:1473-1150 ; Pharmacogenomics Journal, 18, 2, 215-226 |
| Publisher Information: |
Springer Nature |
| Publication Year: |
2018 |
| Collection: |
UNSW Sydney (The University of New South Wales): UNSWorks |
| Subject Terms: |
3214 Pharmacology and Pharmaceutical Sciences; 32 Biomedical and Clinical Sciences; Heart Disease; Aging; Health Disparities and Racial or Ethnic Minority Health Research; Prevention; Genetics; Cardiovascular; Health Disparities; Minority Health; Human Genome; Adult; Aged; 80 and over; Cohort Studies; Electrocardiography; Ethnicity; Female; Genomics; Heart Rate; Humans; Longitudinal Studies; Male; Middle Aged; Pharmacogenetics; Polymorphism; Single Nucleotide; Sodium Chloride Symporter Inhibitors; anzsrc-for: 3214 Pharmacology and Pharmaceutical Sciences; anzsrc-for: 32 Biomedical and Clinical Sciences |
| Description: |
Thiazide diuretics, commonly used antihypertensives, may cause QT interval (QT) prolongation, a risk factor for highly fatal and difficult to predict ventricular arrhythmias. We examined whether common single-nucleotide polymorphisms (SNPs) modified the association between thiazide use and QT or its component parts (QRS interval, JT interval) by performing ancestry-specific, trans-ethnic and cross-phenotype genome-wide analyses of European (66%), African American (15%) and Hispanic (19%) populations (N=78 199), leveraging longitudinal data, incorporating corrected standard errors to account for underestimation of interaction estimate variances and evaluating evidence for pathway enrichment. Although no loci achieved genome-wide significance (P |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
unknown |
| Relation: |
https://hdl.handle.net/1959.4/unsworks_56103; https://doi.org/10.1038/tpj.2017.10 |
| DOI: |
10.1038/tpj.2017.10 |
| Availability: |
https://hdl.handle.net/1959.4/unsworks_56103; https://unsworks.unsw.edu.au/bitstreams/7acccbb0-d112-42ad-82aa-e14562fc52cd/download; https://doi.org/10.1038/tpj.2017.10 |
| Rights: |
open access ; https://purl.org/coar/access_right/c_abf2 ; CC-BY-NC-ND ; https://creativecommons.org/licenses/by-nc-nd/4.0/ ; free_to_read |
| Accession Number: |
edsbas.B3C8843D |
| Database: |
BASE |