| Title: |
Clinical and experimental efficacy of gemtuzumab ozogamicin in core binding factor acute myeloid leukemia |
| Authors: |
Gottardi M; Mosna F; de Angeli S; Papayannidis C; Candoni A; Clavio M; Tecchio C; Piccin A; dell'Orto MC; Benedetti F; Martinelli G; Gherlinzoni F. |
| Contributors: |
Gottardi, M; Mosna, F; de Angeli, S; Papayannidis, C; Candoni, A; Clavio, M; Tecchio, C; Piccin, A; Dell'Orto, Mc; Benedetti, F; Martinelli, G; Gherlinzoni, F. |
| Publication Year: |
2017 |
| Collection: |
Università degli Studi di Verona: Catalogo dei Prodotti della Ricerca (IRIS) |
| Subject Terms: |
ACUTE MYELOID LEUKEMIA; CORE BINDING FACTOR; GEMTUZUMAB OZOGAMICIN |
| Description: |
Leukemia-initiating cells of core binding factor (CBF) acute myeloid leukemia (AML) likely derive from early committed hematopoietic precursors expressing CD33. As such, targeting CD33 could ameliorate the chance of cure of CBF AML patients. We compared 12 CBF AML patients treated with Fludarabine, Cytarabine, Idarubicin and Gemtuzumab Ozogamicin (FLAI-GO regimen) with 25 CBF AML patients treated with the same schedule, but without GO. With the limit of small numbers, we observed a consistent trend toward better overall survival, disease free survival and event free survival in the FLAI-GO group. We also demonstrated the ability of GO to induce the disappearance in vitro of the AML1-ETO molecular transcript in a polymerase chain reaction-positive graft without decreasing the clonogenic potential of CD34+/CD38- cells. This represent the proof of principle for using GO in a purging strategy before autologous stem cell transplantation. Therefore, our data argue in favor of the reinstitution of GO in the therapy of CBF AML. |
| Document Type: |
article in journal/newspaper |
| File Description: |
STAMPA |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/29071049; info:eu-repo/semantics/altIdentifier/wos/WOS:000416645100001; volume:9; issue:3; firstpage:87; lastpage:90; numberofpages:4; journal:HEMATOLOGY REPORTS; https://hdl.handle.net/11562/974146 |
| DOI: |
10.4081/HR.2017.7028 |
| Availability: |
https://hdl.handle.net/11562/974146; https://doi.org/10.4081/HR.2017.7028 |
| Rights: |
info:eu-repo/semantics/openAccess ; license:Dominio pubblico ; license uri:http://creativecommons.org/publicdomain/zero/1.0/ |
| Accession Number: |
edsbas.B3DCF53 |
| Database: |
BASE |