| Title: |
Immune dysregulation through longitudinal lymphocyte trajectories and their clinical determinants in hospitalized COVID-19 patients |
| Authors: |
Cidade, José Pedro; Taccone, Fabio Silvio; Reyes, Luis Felipe; Merson, Laura; Lefèvre, Benjamin; Citarella, Barbara Wanjiru; Fatoni, Arie Zainul; Póvoa, Pedro; Abdalasalam, Sabriya; Abdalhadi, Alaa Abdalfattah; Abdalla, Naana Reyam; Abdalrheem, Almthani Hamza; Abdeewi, Saedah; Abdelgaum, Esraa Hassan; Abdelhalim, Mohamed; Abdelkabir, Mohammed; Abdukahil, Sheryl Ann; Abdulbaqi, Lamees Adil; Abdulkadir, Nurul Najmee; Abdulwahed, Eman; Abdunabi, Rawad; Abe, Ryuzo; Abel, Laurent; Abodina, Ahmed Mohammed; Abrous, Amal; Jabal, Kamal Abu; Salah, Nashat Abu; Abusalama, Abdurraouf; Acharya, Subhash; Acker, Andrew; Adem, Safia; Ademnou, Manuella; Adhikari, Neill; Adu, Samuel Yaw; Awuah, Anthony Afum-Adjei; Agbogbatey, Melvin; Ageel, Saleh Al; Ahmed, Musaab Mohammed; Ahmed, Aya Mustafa; Alaraji, Zainab Ahmed; Enan, Abdulrahman Ahmed Elhefnawy; Khalil, Reham Abdelhamid Ahmed; Abdelaziz, Ali Mostafa Ahmed Mohamed; Ainscough, Kate; Airlangga, Eka; Aisa, Tharwat; Hssain, Ali Ait; Akimoto, Takako; Akmal, Ernita; Akwani, Chika; Qasim, Eman Al; Alajeeli, Ahmed; Alalqam, Razi; Alaraji, Zinah; Albatni, Safa; Alberti, Angela; Al-Dabbous, Tala; Aldoukali, Abdulkarim; Alessi, Marta; Alex, Beatrice; Alexandre, Kévin; Al-Fares, Abdulrahman; Alflite, Asil; Alfoudri, Huda; Alhadad, Qamrah; Alhaddad, Hoda Salem; Alhasan, Maali Khalid Mohamed Abdalla; Alhouri, Hasan; Alhouri, Ahmad Nabil; Ali, Maha Tagelser Mohammed; Ali, Imran; Abdelghafar, Yomna Ali; Alidjnou, Kazali Enagnon; Aljadi, Mahmoud; Aljamal, Sarah; Alkahlout, Mohammed; Alkaseek, Akram; Alkhafajee, Qabas; Allavena, Clotilde; Allou, Nathalie; Almjersah, Abdulrahman; Alrfaea, Walaa; Alrifaee, Moayad; Al-Sabaa, Yousef; Alshareea, Entisar; Alves, João; Alves, João Melo; Alves, Rita; Cabrita, Joana Alves; Amaral, Maria; Amer, Amro Essam; Amira, Nur; Ammerlaan, Heidi; Adusei, Amos Amoako; Amuasi, John; Andini, Roberto; Andrejak, Claire; Angheben, Andrea; Angoulvant, François; Ansart, Séverine; Antonelli, Massimo; Apriyana, Ardiyan; Arabi, Yaseen; Aragao, Irene; Arancibia, Francisco; Arcadipane, Antonio; Archambault, Patrick; Arenz, Lukas; Arlet, Jean-Benoît; Arnold-Day, Christel; Arora, Lovkesh; Artaud-Macari, Elise; Aryal, Diptesh; Asaki, Motohiro; Asensio, Angel; Ashley, Elizabeth; Ashraf, Muhammad; Ashraf, Muhammad Sheharyar; Ashur, Abir Ben; Asiedu-Bekoe, Franklin; Asif, Namra; Asim, Mohammad; Assi, Grace; Assie, Jean Baptiste; Asyraf, Amirul; Atia, Ahmed; Atif, Minahel; Abdallahrs, Asia Atif Abdelrhman; Atique, Anika; Atlowly, Moad; Auchabie, Johann; Aumaitre, Hugues; Auvet, Adrien; Ayad, Ared; Helmi, Ahmed Ayman Hassan; Azemar, Laurène; Azizeldin, Mohammed; Azoulay, Cecile; Bach, Benjamin; Bachelard, Antoine; Bachelet, Delphine; Baillie, John Kenneth; Baird, J. Kevin; Bak, Erica; Bakakos, Agamemnon; Bakar, Nazreen Abu; Bakeer, Hibah Bileid; Bakri, Ashraf; Bal, Andriy; Balakrishnan, Mohanaprasanth; Bandera, Alessandra; Bani-Sadr, Firouzé; Barbosa, Nicholas Yuri; Barclay, Wendy; Barnett, Saef Umar; Barnikel, Michaela; Barrigoto, Cleide; Bartoli, Marie; Bartone, Cheryl; Baruch, Joaquín; Basmaci, Romain; Basri, Muhammad Fadhli Hassin; Batool, Abdalkarim; Battaglini, Denise; Bauer, Jules; Rincon, Diego Fernando Bautista; Bedossa, Alexandra; Bee, Ker Hong; Begum, Husna; Beljantsev, Aleksandr; Beltrão, Beatriz Amorim; Beluze, Marine; Benech, Nicolas; Benjiman, Lionel Eric; Bennett, Suzanne; Bento, Luís; Berdal, Jan-Erik; Bergeaud, Delphine; Sobrino, José Luis Bernal; Bertoli, Giulia; Bertolino, Lorenzo; Bessis, Simon; Betz, Adam; Bevilcaqua, Sybille; Bezulier, Karine; Bhatt, Amar; Bianco, Claudia; Bichoka, Sandra; Bidin, Farah Nadiah; Humaid, Felwa Bin; Kamarudin, Mohd Nazlin Bin; Binnawara, Muhannud; Biston, Patrick; Bitker, Laurent; Blanco-Schweizer, Pablo; Blier, Catherine; Bloos, Frank; Blot, Mathieu; Boccia, Filomena; Bodenes, Laetitia; Bogaert, Debby; Boivin, Anne-Hélène; Bolanga, Ariel; Bolaños, Isabela; Bolze, Pierre-Adrien; Bonifasius, Aurelius; Bonney, Joseph; Borges, Diogo; Borie, Raphaël; Botelho-Nevers, Elisabeth; Bouadma, Lila; Bouaraba, Yasmine; Bouchaud, Olivier; Bouchez, Sabelline; Bouiller, Kévin; Bouillet, Laurence; Bouisse, Camile; Bountthasavong, Latsaniphone; Boureau, Anne-Sophie; Bourke, John; Bouscambert, Maude; Bousquet, Aurore; Boyer-Besseyre, Marielle; Boylan, Maria; Bozza, Fernando Augusto; Braconnier, Axelle; Brazzi, Luca; Breen, Patrick; Brewster, David; Brickell, Kathy; Broadley, Tessa; Bryda, Petra; Buchtele, Nina; Bugaeva, Polina; Buisson, Marielle; Burhan, Erlina; Buri, Donald; Burrell, Aidan; Bustos, Ingrid; Butnaru, Denis; Cabie, André; Cabral, Susana; Cabrita, Joana; Caceres, Eder; Cadoz, Cyril; Garcês, Rui Caetano; Callahan, Mia; Calvache, Jose Andres; Camões, João; Campbell, Paul; Campisi, Josie; Canepa, Cecilia; Cantero, Mireia; Caoili, Janice; Caraux-Paz, Pauline; Cardoso, Filipa; Cardoso, Sofia; Cardoso, Nelson; Cardoso, Filipe; Carelli, Simone; Carlier, Nicolas; Carmoi, Thierry; Carney, Gayle; Carqueja, Inês; Carret, Marie-Christine; Carrier, François Martin; Carroll, Ida; Carvalho, Leonor; Casanova, Maire-Laure; Cascão, Mariana; Casey, Siobhan; Casimiro, José; Cassandra, Bailey; Castañeda, Silvia; Castor-Alexandre, Guylaine; Catarino, Ana; Catherine, François-Xavier; Cauda, Roberto; Cavalli, Giulio- Giovanni; Cavayas, Alexandros; Ceccato, Adrian; Ceriotti, Ferruccio; Cerkovnik, Shelby; Cervantes, Minerva; Cervantes-Gonzalez, Minerva; Cevik, Muge; Chair, Anissa; Chakveatze, Catherine; Chalela, Roberto; Chan, Adrienne; Chand, Meera; Chapplain, Jean-Marc; Charpentier, Charlotte; Chas, Julie; Chaudry, Muhammad -Mobin; Iñiguez, Jonathan Samuel Chávez; Chen, Anjellica; Cheng, Matthew Pellan; Cheret, Antoine; Chiarabini, Thibault; Chica, Julian; Chidambaram, Suresh-Kumar; Tho, Leong Chin; Chirouze, Catherine; Cho, Hwa Jin; Chommanam, Danoy; Chopin, Marie-Charlotte; Chow, Ting Soo; Christy, Nathaniel; Chua, Hiu Jian; Chua, Jonathan; Herreros, José Miguel Cisneros; Ciullo, Anna; Clarke, Jennifer; Granado, Rolando Claure-Del; Clohisey, Sara; Coakley, Peter David; Cody, Caitriona; Coles, Megan; Coles, Jennifer; Colin, Gwenhaël; Collins, Michael; Combs, Pamela; Connolly, Jennifer; Connor, Marie; Conrad, Anne; Conway, Elaine; Cooke, Graham; Cordel, Hugues; Corley, Amanda; Cornelis, Sabine; Corpuz, Arianne Joy; Cortegiani, Andrea; Corvaisier, Grégory; Cotter, Aoife; Couffin-Cadiergues, Sandrine; Courtois, Roxane; Cousse, Stéphanie; Cowan, Juthaporn; Cregan, Rachel; D Orleans, Charles Crepy; Cristella, Cosimo; Crowl, Gloria; Crump, Jonathan; Cruz, Claudina; Bermúdez, Juan Luis Cruz; Rojo, Jaime Cruz; Csete, Marc; Cullen, Ailbhe; Cummings, Matthew; Curley, Gerard; Curlier, Elodie; Curran, Colleen; da Silva Filipe, Ana; da Silveira, Charlene; Dabaliz, Al-Awwab; Dagens, Andrew; Dahly, Darren; Daley, Peter; Dalloul, Zaina; Dalton, Jo; Dalton, Heidi; Daly, Seamus; Damas, Juliana; Dame, Joycelyn; Damien, Cammandji; Daneman, Nick; Dantas, Jorge; de Jong, Menno; de la Calle Prieto, Fernando; de Loughry, Gillian; de Mendoza, Diego; de Montmollin, Etienne; de Pinho Oliveira, Ana Isabel; de Rosa, Rosanna; de Silva, Thushan; de Vries, Peter; Debard, Alexa; Debenedictis, Bianca; Debray, Marie-Pierre; Decastro, Nathalie; Dechert, William; Decours, Romain; Defous, Eve; Delacroix, Isabelle; Delamou, Alexandre; Delavigne, Karen; Delfos, Nathalie; Dell Amore, Andrea; Delmas, Christelle; Delobel, Pierre; Deme, Ismaila; Demonchy, Elisa; Denis, Emmanuelle; Deplanque, Dominique; Depuydt, Pieter; Descamps, Diane; Desvallées, Mathilde; Dewayanti, Santi; Dhangar, Pathik; Diallo, Alpha; Diallo, Souleymane Taran; Diamantis, Sylvain; Dias, Andrea; Dias, André; Diaz, Juan Jose; Diaz, Priscila; Diaz, Rodrigo; Didier, Kévin; Diehl, Jean-Luc; Dinh, Aurélien; Diouf, Alphonsine; Dishon, Yael; Djadda, Cedric; Djossou, Félix; Dobremel, Nikita; Docherty, Annemarie; Doherty, Helen; Dondorp, Arjen; Donnelly, Christl; Donohue, Yoann; Donohue, Sean; Doran, Peter; Dorival, Céline; D Ortenzio, Eric; Douangdala, Phouvieng; Douglas, James Joshua; Dournon, Nathalie; Drake, Thomas; Driscoll, Aoife; Duah, Ibrahim Kwaku; Dubee, Vincent; Dubos, François; Dubot-Pérès, Audrey; Ducancelle, Alexandre; Dudman, Susanne; Duggal, Abhijit; Dunand, Paul; Dunning, Jake; Duplaix, Mathilde; Durante-Mangoni, Emanuele; Durham, Lucian; Dussol, Bertrand; Duval, Xavier; Dyrhol-Riise, Anne Margarita; Ean, Sim-Choon; Echeverria-Villalobos, Marco; Edelstein, Michael; Ehzaz, Khadeja; Eira, Carla; El Sanharawi, Mohammed; Elapavaluru, Subbarao; Elbahnasawy, Mohammad; Elharrar, Brigitte; Elmagrahi, Hamida; Eloundou, Lauren; Eloy, Philippine; Elshazly, Tarek; Elsokni, Wafa; Eltayeb, Aml Ahmed; Elyazar, Iqbal; Emad, Zarief Kamel; Embarek, Hussein; Enderle, Isabelle; Endo, Tomoyuki; Eneli, Gervais; Eng, Chan Chee; Engelmann, Ilka; Enouf, Vincent; Epaulard, Olivier; Esaadi, Haneen; Esperatti, Mariano; Santo, Catarina Espírito; Esposito-Farese, Marina; Essaka, Rachel; Estevão, João; Etienne, Manuel; Everding, Anna Greti; Evers, Mirjam; Fabre, Marc; Fabre, Isabelle; Fadlalla, Asgad Osman Abdalla; Faheem, Amna; Fahy, Arabella; Fairfield, Cameron; Fareed, Komal; Faria, Pedro; Farooq, Ahmed; Fateena, Hanan; Fatima, Salem; Faure, Karine; Favory, Raphaël; Fayed, Mohamed; Feely, Niamh; Feeney, Eoin; Fernandes, Susana; Fernandes, Jorge; Fernandes, Marília Andreia; Ferrand, François-Xavier; Ferrão, Joana; Ferraz, Mário; Ferreira, Isabel; Ferreira, Sílvia; Ferreira, Benigno; Ferreira, Bernardo; Ferriere, Nicolas; Ferroni, Valentina; Ficko, Céline; Flament, Thomas; Fletcher, Tom; Florence, Aline-Marie; Florio, Letizia Lucia; Flynn, Deirdre; Foley, Jean; Fomin, Victor; Fontela, Patricia; Forsyth, Simon; Foster, Denise; Foti, Giuseppe; Fotso, Berline; Fourn, Erwan; Fowler, Robert; Fraher, Marianne; Franch-Llasat, Diego; Frange, Pierre; Fraser, John; Fraser, Christophe; Fritz, Ricardo; Fry, Stéphanie; Fuentes, Nora; Argin, G.; Gaborieau, Valérie; Gaci, Rostane; Gagliardi, Massimo; Gagnard, Jean-Charles; Gagneux-Brunon, Amandine; Gaião, Sérgio; Skeie, Linda Gail; Ramadan, Adham Mohamed Galal Mohamed; Gallagher, Phil; Gamble, Carrol; Gani, Yasmin; Garan, Arthur; Garcia, Rebekha; Barrio, Noelia García; Rodriguez, Julio Garcia; Garcia-Diaz, Julia; Garcia-Gallo, Esteban; Garot, Denis; Garrait, Valérie; Gavrylov, Anatoliy; Gaymard, Alexandre; Gebauer, Johannes; Geraud, Eva; Morlaes, Louis Gerbaud; Germano, Nuno; Ghemmeid, Malak; Ghisulal, Praveen Kumar; Ghosn, Jade; Giani, Marco; Giaquinto, Carlo; Gibowski, Séverine; Gigante, Tristan; Giordano, Guillermo; Girvan, Michelle; Gissot, Valérie; Giwangkancana, Gezy; Glikman, Daniel; Glybochko, Petr; Gnall, Eric; Goco, Geraldine; Goehringer, François; Goepel, Siri; Goffard, Jean-Christophe; Goh, Jin Yi; Golács, Brigitta; Golob, Jonathan; Gomes, Rui; Gómez-Junyent, Joan; Gominet, Marie; Gonzalez, Alicia; Gordon, Patricia; Gorenne, Isabelle; Goubert, Laure; Goujard, Cécile; Goulenok, Tiphaine; Grable, Margarite; Graf, Jeronimo; Grandin, Edward Wilson; Granier, Pascal; Grasselli, Giacomo; Green, Christopher; Greenhalf, William; Greffe, Segolène; Grieco, Domenico Luca; Griffee, Matthew; Griffiths, Fiona; Grigoras, Ioana; Groenendijk, Albert; Grovogui, Fassou Mathias; Gruner, Heidi; Gu, Yusing; Guedj, Jérémie; Guego, Martin; Guerguerian, Anne-Marie; Guerreiro, Daniela; Guery, Romain; Guillaumot, Anne; Guilleminault, Laurent; Guimard, Thomas; Haber, Daniel; Hachemi, Ali; Haddud, Abdurrahman; Hadri, Nadir; Hafez, Wael; Haidri, Fakhir Raza; Hajij, Fatima Mhd Rida; Hakak, Sheeba; Hall, Matthew; Halpin, Sophie; Hamdan, Shaher; Hamdi, Abdelhafeez; Hamer, Ansley; Hamers, Raph; Hamidfar, Rebecca; Hammond, Naomi; Hammond, Terese; Han, Lim Yuen; Hanan, Matly; Haniffa, Rashan; Hao, Kok Wei; Hardwick, Hayley; Harrison, Ewen; Hartman, Alan; Hasan, Mohd Shahnaz; Hasan, Mohammad Ali Nabil; Hasan, Sulieman; Hashmi, Madiha; Hashmi, Junaid; Hassan, Amoni; Hassanin, Ebtisam; Hayat, Muhammad; Hayes, Ailbhe; Hays, Leanne; Heggelund, Lars; Helmi, Ahmed; Hendry, Ross; Hennessy, Martina; Henriquez-Trujillo, Aquiles Rodrigo; Hentzien, Maxime; Hernandez, Diana; Hershey, Andrew; Hidayah, Astarini; Higgins, Eibhlin; Hinton, Samuel; Hiraiwa, Hiroaki; Hites, Maya; Hitoto, Hikombo; Ho, Yi Bin; Ho, Antonia; Hoctin, Alexandre; Hoffmann, Isabelle; Hoh, Wei Han; Hoiting, Oscar; Holter, Jan Cato; Horby, Peter; Horcajada, Juan Pablo; Houderi, Mabrouka; Houltham, Stuart; Hsu, Jimmy Ming-Yang; Hulot, Jean-Sébastien; Hurd, Abby; Hussain, Iqbal; Hussein, Aliae Mohamed; Hussein, Mahmood; Ibrahim, Fatima; Ibran, Bashir; Ijaz, Samreen; Ikram, M. Arfan; Imbert, Patrick; Sikander, Rana Imran; Inácio, Hugo; Dominguez, Carmen Infante; Ing, Yun Sii; Ippolito, Mariachiara; Irawany, Vera; Isgett, Sarah; Isidoro, Tiago; Ismail, Nadiah; Isnard, Margaux; Itai, Junji; Jaafar, Danielle; Jaafoura, Salma; Jaber, Hamza; Jabot, Julien; Jackson, Clare; Janes, Victoria; Jaureguiberry, Stéphane; Javidfar, Jeffrey; Jaworsky, Denise; Jego, Florence; Jelani, Anilawati Mat; Jenum, Synne; Jimbo-Sotomayor, Ruth; Joe, Ong Yiaw; García, Ruth Noemí Jorge; Joseph, Cédric; Joseph, Mark; Joson, Evelyn; Jourdain, Mercé; Jouvet, Philippe; Jung, Anna; Juzar, Dafsah; Kafif, Ouifiya; Kaguelidou, Florentia; Kaisbain, Neerusha; Kali, Sabrina; Kalomoiri, Smaragdi; Kamaluddin, Muhammad Aisar Ayadi; Kamano, Armand Saloun; Kamaruddin, Zul Amali Che; Kamarudin, Nadiah; Kandamby, Darshana Hewa; Kang, Kong Yeow; Kanyawati, Dyah; Karghul, Mohamed; Karpayah, Pratap; Kartsonaki, Christiana; Kasugai, Daisuke; Katz, Kevin; Kay, Christy; Kayyali, Lamees; Keating, Seán; Kelly, Aoife; Kelly, Niamh; Kelly, Sadie; Kelly, Yvelynne; Kelsey, Maeve; Keomany, Sommay; Kernan, Maeve; Kerroumi, Younes; Keshav, Sharma; Khail, Shams; Khaled, Sarah; Khalid, Imrana; Khalil, Zineb; Khalil, Antoine; Khan, Irfan; Khanal, Sushil; Kho, Michelle; Khoo, Denisa; Khoo, Saye; Khoo, Ryan; Khoso, Muhammad Nasir; Kiat, Khor How; Kida, Yuri; Kiiza, Peter; Granerud, Beathe Kiland; Kildal, Anders Benjamin; Kim, Jae Burm; Kimmoun, Antoine; Klenerman, Paul; Bekken, Gry Kloumann; Knight, Stephen; Kobbe, Robin; Kodippily, Chamira; Koirala, Sabin; Kouba, Stephanie; Kourouma, Karifa; Kourouma, Mohamed Lamine; Krawczyk, Karolina; Kredan, Ali; Krishnan, Vinothini; Krishnan, Sudhir; Kruglova, Oksana; Krund, Anneli; Kuan, Pei Xuan; Kumar, Ganesh; Kumar, Deepali; Kuriakose, Dinesh; Kurtzman, Ethan; Kutsogiannis, Demetrios; Kutsyna, Galyna; Kwedi, Sylvie; Kyriakoulis, Konstantinos; Lachatre, Marie; Lacombe, Karine; Lacoste, Marie; Laffey, John; Lafhej, Nadhem; Lagrange, Marie; Laine, Fabrice; Lairez, Olivier; Lalueza, Antonio; Lambert, Marc; Langelot-Richard, Marie; Langlois, Vincent; Laouénan, Cédric; Laribi, Samira; Lariviere, Delphine; Laroza, Jamaica; Lasry, Stéphane; Latifeh, Youssef; Launay, Odile; Laureillard, Didier; Lavie-Badie, Yoan; Law, Andy; Lawrence, Teresa; Le, Minh; Le Bihan, Clément; Le Bris, Cyril; Le Falher, Georges; Le Fevre, Lucie; Le Hingrat, Quentin; Le Maréchal, Marion; Le Mestre, Soizic; Le Meut, Guillaume; Le Moal, Gwenaël; Le Moing, Vincent; Le Nagard, Hervé; Leal, Ema; Santos, Marta Leal; Lee, Yi Lin; Lee, Heng Gee; Lee, James; Lee, Biing Horng; Lee, Todd; Leeming, Gary; Lefebvre, Bénédicte; Lefebvre, Laurent; Legac, Sylvie; Lehiste, Merili-Helen; Lelievre, Jean-Daniel; Lellouche, François; Lemaignen, Adrien; Lemee, Véronique; Lemeur, Anthony; Lemmink, Gretchen; Lene, Ha Sha; Lennon, Jenny; Leone, Marc; Lepik, Tanel; Lepiller, Quentin; Lescure, François-Xavier; Lesouhaitier, Mathieu; Letizia, Andrew; Letrou, Sophie; Levy, Bruno; Levy, Yves; Levy-Marchal, Claire; Lewandowska, Katarzyna; Bassi, Gianluigi Li; Liang, Janet; Liegeon, Geoffrey; Lim, Wei Shen; Lim, Kah Chuan; Lima, Chantre; Lina, Lim; Lina, Bruno; Lind, Andreas; Lingas, Guillaume; Lion-Daolio, Sylvie; Liu, Keibun; Livrozet, Marine; Lizotte, Patricia; Loforte, Antonio; Lolong, Navy; Loon, Leong Chee; Lopes, Diogo; Lopez-Colon, Dalia; López-Revilla, Jose; Loschner, Anthony; Loubet, Paul; Loufti, Bouchra; Louis, Guillame; Lourenco, Silvia; Low, Lee Lee; Loy, Jia Shyi; Bermejo, Carlos Lumbreras; Luna, Carlos; Lungu, Olguta; Lunn, Miles; Luong, Liem; Luque, Nestor; Luton, Dominique; Maasikas, Olavi; Machado, Moïse; Machado, Sara; Macheda, Gabriel; Madelaine, Claire; de la Calle, Guillermo Maestro; Mahieu, Rafael; Mahy, Sophie; Maia, Ana Raquel; Maier, Lars; Ascofare, Oumou Maiga; Maillet, Mylène; Majeed, Nimisha Abdul; Malfertheiner, Maximilian; Malik, Nadia; Malik, Wajeeha; Malla, Dayana; Mallon, Paddy; Maltez, Fernando; Malvy, Denis; Manda, Victoria; Mandelbrot, Laurent; Manetta, Frank; Mankikian, Julie; Manning, Edmund; Manuel, Aldric; Maráczi, Veronika; Markowicz, Samuel; Marques, Ana; Marshal, Megan; Marshall, John; Martin, Dori-Ann; Martin, Emily; Martin-Blondel, Guillaume; Martinez, F. Eduardo; Martin-Loeches, Ignacio; Martinot, Martin; Martín-Quiros, Alejandro; Martins, João; Martins, Nuno; Martins, Ana; Martucci, Gennaro; Martynenko, Olga; Marwali, Eva Miranda; Marzukie, Marsilla; Maslove, David; Mason, Sabina; Masood, Sobia; Massoma, Moise; Masumbe, Palmer; Nor, Mohd Basri Mat; Matan, Moshe; Mathew, Christina; Mattei, Mathieu; Maulin, Laurence; May, Juergen; Mayxay, Mayfong; Mazzoni, Thierry; Sweeney, Lisa Mc; Mcarthur, Colin; Mccanny, Peter; Mccarthy, Aine; Mccloskey, Colin; Mcconnochie, Rachael; Mcdermott, Sherry; Mcdonald, Sarah; Mcevoy, Natalie; Mcgeer, Allison; Mclean, Kenneth; Mcnally, Paul; Mcnicholas, Bairbre; Meaney, Edel; Mear-Passard, Cécile; Mechlin, Maggie; Mehkri, Omar; Mele, Ferruccio; Mendes, João João; Menon, Kusum; Mentré, France; Mentzer, Alexander; Mercier, Emmanuelle; Merckx, Antoine; Mergeay-Fabre, Mayka; Mesquita, António; Metwally, Osama; Meybeck, Agnès; Meyer, Dan; Mezidi, Mehdi; Michelet, Isabelle; Mihelis, Efstathia; Mihnovit, Vladislav; Abdullah, Duha Milad; Miller, Jennene; Miranda-Maldonado, Hugo; Misnan, Nor Arisah; Mohamed, Tahira Jamal; Mohamed, Nouralsabah; Mohamed, Nik Nur Eliza; Ads, Alaa Mohamed; Abdelhalim, Ahmed Reda Mohamed Elsayed; Mostafa, Shrouk Fawze Mohammed; Mohammedelhassan, Omer Abdullah; Moharam, Saad; Molino, Diana; Molinos, Elena; Molloy, Brenda; Moloney, Geraldine; Mone, Mary; Monteiro, Agostinho; Montes, Claudia; Montrucchio, Giorgia; Moore, Sarah; Moore, Shona; Cely, Lina Morales; Morgom, Marwa; Moro, Lucia; Motos, Ana; Perrot, Clara Mouton; Moyet, Julien; Mualla, Suleiman Haitham; Mufti, Aisha Kalsoom; Muh, Ng Yong; Muhaisen, Mo Nes; Muhamad, Dzawani; Mullaert, Jimmy; Müller, Karl Erik; Müller, Fredrik; Munblit, Daniel; Ali, Syed Muneeb; Munshi, Laveena; Murphy, Aisling; Murray, Patrick; Murris, Marlène; Murthy, Srinivas; Musaab, Himed; Mustafa, Dana; Myrodia, Dimitra Melia; Mohd-Hanafiah, Farah Nadia; Nagpal, Dave; Nagybányai-Nagy, Blanka; Boudoin, Herwin Nanda; Narasimhan, Mangala; Metri, Adel Gerges Nassif; Neant, Nadège; Necsoi, Coca; Nekliudov, Nikita; Nelder, Matthew; Nelwan, Erni Juwita; Neumann, Emily; Ng, Wing Yiu; Ng, Pauline Yeung; Nghi, Anthony; Nguyen, Duc; Choileain, Orna Ni; Leathlobhair, Niamh Ni; Niba, Nerissa; Nichol, Alistair; Noordin, Nurul Amani Mohd; Norharizam, Nurul Faten Izzati; Noursadeghi, Mahdad; Nowinski, Adam; Nseir, Saad; Numfor, Leonard; Nurnaningsih, Nurnaningsih; Nusantara, Dwi Utomo; Nyamankolly, Elsa; Brien, Fionnuala; Callaghan, Annmarie; O Callaghan, Annmarie; Occhipinti, Giovanna; O Connell, Sarah; Oconnor, Derbrenn; O Donnell, Max; Oduro-Mensah, Ebenezer; Ogston, Tawnya; Ogura, Takayuki; Oh, Tak-Hyuk; O Halloran, Sophie; O Hearn, Katie; Ohene, Sally-Ann; Ohshimo, Shinichiro; Oldakowska, Agnieszka; Oliveira, João; Oliver-Commey, Joseph; Olliaro, Piero; Olsen, Inge Christoffer; Omer, Alsarrah Ali Mohammed; Ondobo, Pierre; Ong, David; Ong, Jee Yan; Oosthuyzen, Wilna; Openshaw, Peter; Orakzai, Saijad; Orozco-Chamorro, Claudia Milena; Soliman, Mohamed Osama Elsayed; O Shea, Linda; O Sullivan, Miriam; Othman, Siti Zubaidah; Othman, Eman; Ouissa, Rachida; Owoo, Christian; Owusu, Micheal; Owusu-Asare, Ama Akyampomaa; Oziol, Eric; Pacheco, Patricia; Pagadoy, Maïder; Pages, Justine; Palmarini, Massimo; Palmieri, Carlo; Panarello, Giovanna; Panda, Prasan Kumar; Paneru, Hem; Pang, Lai Hui; Panigada, Mauro; Pansu, Nathalie; Papadopoulos, Aurélie; Parke, Rachael; Parker, Melissa; Pastene, Bruno; Patauner, Fabian; Pathmanathan, Mohan Dass; Patrão, Luís; Patricio, Patricia; Patterson, Lisa; Paul, Christelle; Paul, Mical; Paulos, Jorge; Paxton, William; Payen, Jean-François; Peake, Sandra; Peariasamy, Kalaiarasu; Jiménez, Miguel Pedrera; Peek, Giles; Peelman, Florent; Peiffer-Smadja, Nathan; Peigne, Vincent; Pejkovska, Mare; Pelosi, Paolo; Pereira, Rui; Perez, Daniel; Perpoint, Thomas; Pesenti, Antonio; Pessey, Lenina; Pestre, Vincent; Petrou, Lenka; Petrovic, Michele; Petrov-Sanchez, Ventzislava; Peytavin, Gilles; Philips, Richard Odame; Phonemixay, Ooyanong; Phoutthavong, Soulichanya; Piagnerelli, Michael; Pialoux, Gilles; Picone, Olivier; de Piero, Maria; Pimentel, Carlos; Pinto, Raquel; Pires, Catarina; Piroth, Lionel; Pitaloka, Ayodhia; Piubelli, Chiara; Pius, Riinu; Piva, Simone; Plantier, Laurent; Png, Hon Shen; Poissy, Julien; Pokeerbux, Ryadh; Pokorska-Spiewak, Maria; Poli, Sergio; Pollakis, Georgios; Ponscarme, Diane; Popielska, Jolanta; Porto, Diego Bastos; Post, Andra-Maris; Postma, Douwe; Pourcher, Valérie; Póvoas, Diana; Powis, Jeff; Prapa, Sofia; Praphasiri, Viladeth; Preau, Sébastien; Prebensen, Christian; Preiser, Jean-Charles; Prinssen, Anton; Priyadarshani, Gamage Dona Dilanthi; Proença, Lucia; Pudota, Sravya; Semedi, Bambang Pujo; Puplampu, Peter; Purcell, Gregory; Quesada, Luisa; González, Víctor Quirós; Quist-Paulsen, Else; Quraishi, Mohammed; Qutishat, Fadi; Rabaud, Christian; Rabindrarajan, Ebenezer; Rafael, Aldo; Rafiq, Marie; Ragab, Abdelrahman; Rahardjani, Mutia; Rahman, Rozanah Abd; Rahman, Ahmad Kashfi Haji Ab; Rainieri, Fernando; 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| Contributors: |
Intensive Care Unit 4, Department of Intensive Care, São Francisco Xavier Hospital, ULSLO, Lisbon; NOVA Medical School - Faculdade de Ciências Médicas (NMS); Universidade Nova de Lisboa = NOVA University Lisbon (NOVA); Université libre de Bruxelles = Free University of Brussels (ULB); Hôpital Universitaire de Bruxelles (HUB); Universidad de La Sabana Chía, Cundinamarca, Colombia = La Sabana University Chía, Cundinamarca, Colombia (Unisabana); University of Oxford; Institut Pasteur de Dakar; Pasteur Network (Réseau International des Instituts Pasteur); Université de Lorraine (UL); INterdisciplinarité en Santé Publique Interventions et Instruments de mesure complexes (INSPIIRE); Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL); Faculté de Médecine Nancy; Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy); Service des Maladies Infectieuses et Tropicales CHRU Nancy; Brawijaya University (UB); Odense University Hospital (OUH); Department of Molecular Medicine Oslo; Institute of Basic Medical Sciences Oslo; Faculty of Medicine Oslo; University of Oslo (UiO)-University of Oslo (UiO)-Faculty of Medicine Oslo; University of Oslo (UiO)-University of Oslo (UiO); University of Oslo (UiO); Department of Medical Laboratories Sciences, Faculty of Medical Technology, The University of Tripoli, Libya.; Imagine - Institut des maladies génétiques (IHU) (Imagine - U1163); Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité); Hôpital Necker - Enfants Malades AP-HP; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP); Rockefeller University New York; French COVID cohort study group; Department of Mathematics and Statistics; Wichita State University |
| Source: |
ISSN: 2197-425X. |
| Publisher Information: |
CCSD; Springer |
| Publication Year: |
2026 |
| Subject Terms: |
Multistate analysis; Corticosteroids; COVID19; (3-10 keywords): Lymphopenia; (3-10 keywords): Lymphopenia Immunity Sepsis In-hospital mortality COVID19 Multistate analysis Corticosteroids; (3-10 keywords): Lymphopenia Immunity Sepsis In-hospital mortality COVID-19 Multistate analysis Corticosteroids Tables: 3 Figures: 5; Lymphopenia; Immunity; Sepsis; In-hospital mortality; COVID-19; Corticosteroids Tables: 3 Figures: 5; [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases |
| Description: |
International audience ; AbstractObjective Immune dysregulation plays a pivotal role in the pathophysiology of sepsis and COVID-19, with lymphopenia emerging as a consistent marker of severity and poor prognosis. However, most existing studies have assessed lymphocyte counts at isolated time points, limiting insights into their temporal behavior and prognostic value. The dynamics of lymphocyte recovery or persistence of lymphopenia remain largely unexplored in large populations, as well as the impact of adjunctive therapies such as corticosteroids. We hypothesized that the persistence or recovery of lymphopenia may be key to understanding disease progression and predicting outcomes. Using the multinational ISARIC cohort, we investigated longitudinal lymphocyte trajectories in hospitalized patients and the clinical determinants associated with their evolution over time. Methods We conducted a multinational prospective observational cohort study using data from the ISARIC-WHO Clinical Characterization Protocol. Patients with confirmed SARS-CoV-2 infection and at least four lymphocyte measurements during the first 28 days of hospitalization were included. We analyzed lymphocyte trajectories, Cox regression survival analyses and multivariable linear regression modelling. We also applied multistate models and joint modeling to assess the association between lymphocyte trajectories and 28-day mortality, incorporating corticosteroid use as a time-varying covariate. Results Of 945,317 screened patients, 231,933 hospitalized adults with confirmed COVID-19 and sufficient lymphocyte data were included, with 56.6% classified as lymphopenic. Lymphopenia was independently associated with higher rates of ICU admission, organ support, and in-hospital mortality (OR = 1.52, 95% CI 1.48–1.55), and lower absolute lymphocyte counts were strongly linked to worse survival in adjusted Cox models (HR = 1.33 per 1 × 10⁹ cells/L decrease, 95% CI 1.28–1.38). Multistate modeling revealed that lymphopenic patients had a significantly higher ... |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/41649739; PUBMED: 41649739; PUBMEDCENTRAL: PMC12881241 |
| DOI: |
10.1186/s40635-026-00864-x |
| Availability: |
https://hal.science/hal-05501498; https://hal.science/hal-05501498v1/document; https://hal.science/hal-05501498v1/file/Manuscript_ISARIC_lymphopenia.pdf; https://doi.org/10.1186/s40635-026-00864-x |
| Rights: |
https://creativecommons.org/licenses/by/4.0/ ; info:eu-repo/semantics/OpenAccess |
| Accession Number: |
edsbas.B3EE84EF |
| Database: |
BASE |