| Title: |
T cell trafficking in human chronic inflammatory diseases |
| Authors: |
Giovenzana A.; Codazzi V.; Pandolfo M.; Petrelli A. |
| Contributors: |
Giovenzana, A; Codazzi, V; Pandolfo, M; Petrelli, A |
| Publisher Information: |
Cell Press Elsevier Inc; US |
| Publication Year: |
2024 |
| Collection: |
Università degli Studi di Milano-Bicocca: BOA (Bicocca Open Archive) |
| Subject Terms: |
components of the immune system; human metabolism; immunology; physiology |
| Description: |
Circulating T cells, which migrate from the periphery to sites of tissue inflammation, play a crucial role in the development of various chronic inflammatory conditions. Recent research has highlighted subsets of tissue-resident T cells that acquire migratory capabilities and re-enter circulation, referred to here as “recirculating T cells.” In this review, we examine recent advancements in understanding the biology of T cell trafficking in diseases where T cell infiltration is pivotal, such as multiple sclerosis and inflammatory bowel diseases, as well as in metabolic disorders where the role of T cell migration is less understood. Additionally, we discuss current insights into therapeutic strategies aimed at modulating T cell circulation across tissues and the application of state-of-the-art technologies for studying recirculation in humans. This review underscores the significance of investigating T trafficking as a novel potential target for therapeutic interventions across a spectrum of human chronic inflammatory diseases. |
| Document Type: |
article in journal/newspaper |
| File Description: |
ELETTRONICO |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/39171290; info:eu-repo/semantics/altIdentifier/wos/WOS:001283459400001; volume:27; issue:8; journal:ISCIENCE; https://hdl.handle.net/10281/504765 |
| DOI: |
10.1016/j.isci.2024.110528 |
| Availability: |
https://hdl.handle.net/10281/504765; https://doi.org/10.1016/j.isci.2024.110528 |
| Rights: |
info:eu-repo/semantics/openAccess ; license:Creative Commons ; license uri:http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Accession Number: |
edsbas.B40AD197 |
| Database: |
BASE |