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Lixisenatide in patients with type 2 diabetes and acute coronary syndrome

Title:	Lixisenatide in patients with type 2 diabetes and acute coronary syndrome
Authors:	Pfeffer, Marc A.; Claggett, Brian; Diaz, Rafael; Dickstein, Kenneth; Gerstein, Hertzel C.; Køber, Lars V.; Lawson, Francesca C.; Ping, Lin; Wei, Xiaodan; Lewis, Eldrin F.; Maggioni, Aldo P.; McMurray, John J. V.; Probstfield, Jeffrey L.; Riddle, Matthew C.; Solomon, Scott D.; Tardif, Jean-Claude; ELIXA Investigators; Aizenberg D; Alvarez C; Alvarisqueta A; Baccaro C; Bartolacci I; Bordonava A; Bustamante Labarta M; Caccavo A; Calella P; Cantero M; Codutti R; Commendatore V; Costamagna O; Cuello J; Fernandez A; Garcia Duran R; Gomez Vilamajo O; Gorban De Lapertosa S; Grinfeld D; Hermida S; Lagrutta M; Leon De La Fuente R; Licheri A; Luciardi H; Mackinnon I; Maffei L; Marino J; Montaña O; Novaretto L; Orio S; Orlandini A; Oviedo A; Patocchi C; Pérez Manghi F; Ramos H; Rolandi F; Saa Zarandon R; Saavedra SS; Schiavi L; Schygiel P; Trivi M; Ulla M; Urdiales P; Vallejos J; Vico M; Waisman F; Amerena J; Paul V; Sangla K; Van Gaal W; Yeap B; Fasching P; Pieber T; Danilova L; Mitkovskaya N; Sudzhaeva S; Mathieu C; Pouleur AC; Botelho RV; Cerqueira MJ; Chacra A; De Moraes Junior J; Dos Santos F; Feitosa G; Filho F; Forti A; Golbert M; Halpern A; Hissa M; Lisboa H; Nery M; Quadros A; Raduan R; Reis G; Rollin G; Rossi P; Santos E; Sgarbi J; Souza J; Souza MR; Delchev A; Ivanov V; Klyuchkova N; Kyoleyan M; Levterov G; Lucheva M; Raev D; Shumkova R; Tokmakova M; Tzekova M; Yordanov V; Bailey G; Bertrand O; Bhargava R; Burton J; Campeau J; Dumas R; Filteau P; Syan G; Syan R; Tardif JC; Tsoukas G; Warnica JW; Acuña S; Araneda G; Bunster L; Cobos L; Corbalán R; Dussaillant G; Eggers G; Florenzano F; Godoy G; Huidobro LA; Lahsen R; Lanas F; Larenas G; Manriquez L; Medina M; Palma JC; Perez L; Potthoff S; Raffo C; Reyes E; Saavedra V; Sanhueza P; Sepulveda P; Solis CL; Soto N; Torres C; Westerberg B; Yañez M; Chen L; Dong Y; Du J; Guo X; Han P; Hu T; Jiang B; Ke Y; Li Z; Lu J; Ma C; Peng Y; Shi Y; Su G; Tang B; Xu B; Yang J; Yang Y; Accini JL; Arana C; Arteaga JM; Botero R; Castillo G; Coronel J; Cure C; De Salazar M; Garcia H; Garcia L; Gomez C; Hernandez Triana E; Hernandez H; Lopez M; Lopez P; Manzur F; Rodriguez J; Sanchez Vallejo G; Yupanqui H; Bronnum-Schou J; Kaiser Nielsen P; Nielsen H; 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Contributors:	Pfeffer, Marc A.; Claggett, Brian; Diaz, Rafael; Dickstein, Kenneth; Gerstein, Hertzel C.; Køber, Lars V.; Lawson, Francesca C.; Ping, Lin; Wei, Xiaodan; Lewis, Eldrin F.; Maggioni, Aldo P.; Mcmurray, John J. V.; Probstfield, Jeffrey L.; Riddle, Matthew C.; Solomon, Scott D.; Tardif, Jean-Claude; Elixa, Investigator; Aizenberg, D; Alvarez, C; Alvarisqueta, A; Baccaro, C; Bartolacci, I; Bordonava, A; Bustamante Labarta, M; Caccavo, A; Calella, P; Cantero, M; Codutti, R; Commendatore, V; Costamagna, O; Cuello, J; Fernandez, A; Garcia Duran, R; Gomez Vilamajo, O; Gorban De Lapertosa, S; Grinfeld, D; Hermida, S; Lagrutta, M; Leon De La Fuente, R; Licheri, A; Luciardi, H; Mackinnon, I; Maffei, L; Marino, J; Montaña, O; Novaretto, L; Orio, S; Orlandini, A; Oviedo, A; Patocchi, C; Pérez Manghi, F; Ramos, H; Rolandi, F; Saa Zarandon, R; Saavedra, S; Schiavi, L; Schygiel, P; Trivi, M; Ulla, M; Urdiales, P; Vallejos, J; Vico, M; Waisman, F; Amerena, J; Paul, V; Sangla, K; Van Gaal, W; Yeap, B; Fasching, P; Pieber, T; Danilova, L; Mitkovskaya, N; Sudzhaeva, S; Mathieu, C; Pouleur, Ac; Botelho, Rv; Cerqueira, Mj; Chacra, A; De Moraes Junior, J; Dos Santos, F; Feitosa, G; Filho, F; Forti, A; Golbert, M; Halpern, A; Hissa, M; Lisboa, H; Nery, M; Quadros, A; Raduan, R; Reis, G; Rollin, G; Rossi, P; Santos, E; Sgarbi, J; Souza, J; Souza, Mr; Delchev, A; Ivanov, V; Klyuchkova, N
Publication Year:	2015
Collection:	Università degli Studi del Piemonte Orientale: CINECA IRIS
Subject Terms:	Acute Coronary Syndrome; Aged; Angina; Unstable; Cardiovascular Disease; Diabetes Mellitus; Type 2; Female; Glucagon-Like Peptide-1 Receptor; Glycated Hemoglobin A; Human; Hypoglycemic Agent; Kaplan-Meier Estimate; Male; Middle Aged; Myocardial Infarction; Peptide; Proportional Hazards Model; Treatment Failure; Medicine (all)
Description:	Cardiovascular morbidity and mortality are higher among patients with type 2 diabetes, particularly those with concomitant cardiovascular diseases, than in most other populations. We assessed the effects of lixisenatide, a glucagon-like peptide 1-receptor agonist, on cardiovascular outcomes in patients with type 2 diabetes who had had a recent acute coronary event. METHODS: We randomly assigned patients with type 2 diabetes who had had a myocardial infarction or who had been hospitalized for unstable angina within the previous 180 days to receive lixisenatide or placebo in addition to locally determined standards of care. The trial was designed with adequate statistical power to assess whether lixisenatide was noninferior as well as superior to placebo, as defined by an upper boundary of the 95% confidence interval for the hazard ratio of less than 1.3 and 1.0, respectively, for the primary composite end point of cardiovascular death, myocardial infarction, stroke, or hospitalization for unstable angina. RESULTS: The 6068 patients who underwent randomization were followed for a median of 25 months. A primary end-point event occurred in 406 patients (13.4%) in the lixisenatide group and in 399 (13.2%) in the placebo group (hazard ratio, 1.02; 95% confidence interval [CI], 0.89 to 1.17), which showed the noninferiority of lixisenatide to placebo (P
Document Type:	article in journal/newspaper
Language:	English
Relation:	info:eu-repo/semantics/altIdentifier/pmid/26630143; info:eu-repo/semantics/altIdentifier/wos/WOS:000365743100008; volume:373; issue:23; firstpage:2247; lastpage:2257; numberofpages:11; journal:NEW ENGLAND JOURNAL OF MEDICINE; http://hdl.handle.net/11579/101042
DOI:	10.1056/NEJMoa1509225
Availability:	http://hdl.handle.net/11579/101042; https://doi.org/10.1056/NEJMoa1509225; http://www.nejm.org/doi/pdf/10.1056/NEJMoa1509225
Accession Number:	edsbas.B484B0C3
Database:	BASE