| Title: |
Differential Long-Term Effects of First- and Second-Generation DES in Patients With Bifurcation Lesions Undergoing PCI |
| Authors: |
Choi, KH; Song, YB; Lee, JM; Park, TK; Yang, JH; Hahn, JY; Choi, JH; Choi, SH; Kim, HS; Chun, WJ; Hur, SH; Han, SH; Rha, SW; Chae, IH; Jeong, JO; Heo, JH; Yoon, J; Lim, DS; Park, JS; Hong, MK; Doh, JH; Cha, KS; Kim, DI; Lee, SY; Chang, K; Hwang, BH; Choi, SY; Jeong, MH; Hong, SJ; Nam, CW; Koo, BK; Gwon, HC |
| Contributors: |
101511; Choi, SY |
| Publication Year: |
2021 |
| Subject Terms: |
bifurcation; drug-eluting stents; outcomes; percutaneous coronary intervention |
| Description: |
Background: There is a paucity of data regarding the long-term clinical outcomes of first- versus second-generation drug-eluting stent (DES), especially when used to treat complex lesions such as bifurcation lesions. Objectives: The current study compares the efficacy and safety of first- versus second-generation DES at the 5-year follow-up in patients who underwent bifurcation percutaneous coronary intervention (PCI). Methods: A total of 5,498 patients with a bifurcation lesion who underwent PCI were pooled at a single patient level from COBIS (Coronary Bifurcation Stenting) registries II and III. Five-year target lesion failure (TLF) (the composite of cardiac death, myocardial infarction [MI], and target lesion revascularization [TLR]) and cardiac death or MI were compared between the use of first-generation DES (n = 2,436) and second-generation DES (n = 3,062) during PCI. Propensity score matching was performed to reduce selection bias. Results: After a 1:1 propensity score matching procedure was conducted, the cohort consisted of 1,702 matched pairs. Patients treated with second-generation DES had a significantly lower risk of TLF at 5 years than those treated with first-generation DES in both overall and propensity-matched populations (matched hazard ratio [HRmatched]: 0.576; 95% confidence interval [CI]: 0.456 to 0.727; p |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| ISSN: |
36338362 |
| Relation: |
J027723747; http://repository.ajou.ac.kr/handle/201003/23411; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9627880/ |
| DOI: |
10.1016/j.jacasi.2021.04.006 |
| Availability: |
http://repository.ajou.ac.kr/handle/201003/23411; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9627880/; https://doi.org/10.1016/j.jacasi.2021.04.006 |
| Accession Number: |
edsbas.B4AC6811 |
| Database: |
BASE |