| Title: |
California verbal learning test-ii performance in schizophrenia as a function of ascertainment strategy: Comparing the first and second phases of the consortium on the genetics of schizophrenia (COGS) |
| Authors: |
Stone, WS; Mesholam-Gately, RI; Braff, DL; Calkins, ME; Freedman, R; Green, MF; Greenwood, TA; Gur, RE; Gur, RC; Lazzeroni, LC; Light, GA; Nuechterlein, KH; Olincy, A; Radant, AD; Siever, LJ; Silverman, JM; Sprock, J; Sugar, CA; Swerdlow, NR; Tsuang, DW; Tsuang, MT; Turetsky, BI; Seidman, LJ |
| Source: |
Schizophrenia Research, vol 163, iss 1-3 |
| Publisher Information: |
eScholarship, University of California |
| Publication Year: |
2015 |
| Collection: |
University of California: eScholarship |
| Subject Terms: |
Medical and Health Sciences; Psychology and Cognitive Sciences; Psychiatry |
| Subject Geographic: |
32 - 37 |
| Description: |
The first phase of the Consortium on the Genetics of Schizophrenia (COGS-1) showed performance deficits in learning and memory on the California Verbal Learning Test, Second Edition (CVLT-II) in individuals with schizophrenia (SZ), compared to healthy comparison subjects (HCS). A question is whether the COGS-1 study, which used a family study design (i.e. studying relatively intact families), yielded "milder" SZ phenotypes than those acquired subsequently in the COGS-2 case-control design that did not recruit unaffected family members. CVLT-II performance was compared for the COGS-1 and COGS-2 samples. Analyses focused on learning, recall and recognition variables, with age, gender and education as covariates. Analyses of COGS-2 data explored effects of additional covariates and moderating factors in CVLT-II performance. 324 SZ subjects and 510 HCS had complete CVLT-II and covariate data in COGS-1, while 1356 SZ and 1036 HCS had complete data in COGS-2. Except for recognition memory, analysis of covariance showed significantly worse performance in COGS-2 on all CVLT-II variables for SZ and HCS, and remained significant in the presence of the covariates. Performance in each of the 5 learning trials differed significantly. However, effect sizes comparing cases and controls were comparable across the two studies. COGS-2 analyses confirmed SZ performance deficits despite effects of multiple significant covariates and moderating factors. CVLT-II performance was worse in COGS-2 than in COGS-1 for both the SZ and the HCS in this large cohort, likely due to cohort effects. Demographically corrected data yield a consistent pattern of performance across the two studies in SZ. |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
unknown |
| Relation: |
qt2713399g; https://escholarship.org/uc/item/2713399g; https://escholarship.org/content/qt2713399g/qt2713399g.pdf |
| DOI: |
10.1016/j.schres.2014.10.029 |
| Availability: |
https://escholarship.org/uc/item/2713399g; https://escholarship.org/content/qt2713399g/qt2713399g.pdf; https://doi.org/10.1016/j.schres.2014.10.029 |
| Rights: |
public |
| Accession Number: |
edsbas.B50B4F70 |
| Database: |
BASE |