Analysis of comorbidities and multimorbidity in adult patients in the International Severe Asthma Registry
| Title: | Analysis of comorbidities and multimorbidity in adult patients in the International Severe Asthma Registry |
|---|---|
| Authors: | Scelo G.; Torres Duque C.A.; Maspero J.; Tran T.N.; Murray R.; Martin N.; Menzies Gow A.N.; Hew M.; Peters M.J.; Gibson P.G.; Christoff G.C.; Popov T.A.; Côté A.; Bergeron C.; Dorscheid D.; FitzGerald J.M.; Chapman K.R.; Boulet L.P.; Bhutani M.; Sadatsafavi M.; Jiménez Maldonado L.; Duran Silva M.; Rodriguez B.; Celis Preciado C.A.; Cano Rosales D.J.; Solarte I.; Fernandez Sanchez M.J.; Parada Tovar P.; von Bülow A.; Bjerrum A.S.; Ulrik C.S.; Assing K.D.; Rasmussen L.M.; Hansen S.; Altraja A.; Bourdin A.; Taille C.; Charriot J.; Roche N.; Papaioannou A.I.; Kostikas K.; Papadopoulos N.G.; Salvi S.; Long D.; Mitchell P.D.; Costello R.; Sirena C.; Cardini C.; Heffler E.; Puggioni F.; Canonica G.W.; Guida G.; Iwanaga T.; Al Ahmad M.; Linnemann D.L.; Garcia U.; Kuna P.; Fonseca J.A.; Al Lehebi R.; Koh M.S.; Rhee C.K.; Cosio B.G.; de Llano L.P.; Perng (Steve) D. W.; Huang E.W. C.; Wang H. C.; Tsai M. J.; Mahboub B.; Salameh L.I.J.; Jackson D.; Busby J.; Heaney L.G.; Pfeffer P.; Goddard A.G.; Wang E.; Hoyte F.; Wechsler M.E.; Chapman N.; Katial R.; Carter V.; Bulathsinhala L.; Eleangovan N.; Ariti C.; Lyu J.; Price D.B.; Porsbjerg C. |
| Source: | Universidad de La Sabana ; Intellectum Repositorio Universidad de La Sabana |
| Publisher Information: | Annals of Allergy, Asthma and Immunology |
| Publication Year: | 2024 |
| Collection: | Repositorio Universidad de La Sabana |
| Description: | 9 páginas ; Background: Investigation for the presence of asthma comorbidities is recommended by the Global Initiative for Asthma because their presence can complicate asthma management. Objective: To understand the prevalence and pattern of comorbidities and multimorbidity in adults with severe asthma and their association with asthma-related outcomes. Methods: This was a cross-sectional study using data from the International Severe Asthma Registry from 22 countries. A total of 30 comorbidities were identified and categorized a priori as any of the following: (1) potentially type 2¿related comorbidities, (2) potentially oral corticosteroid (OCS)¿related comorbidities, or (3) comorbidities mimicking or aggravating asthma. The association between comorbidities and asthma-related outcomes was investigated using multivariable models adjusted for country, age at enrollment, and sex (ie male or female). Results: Of the 11,821 patients, 69%, 67%, and 55% had at least 1 potentially type 2¿related, potentially OCS-related, or mimicking or aggravating comorbidities, respectively; 57% had 3 or more comorbidities, and 33% had comorbidities in all 3 categories. Patients with allergic rhinitis, nasal polyposis, and chronic rhinosinusitis experienced 1.12 (P = .003), 1.16 (P < .001), and 1.29 times (P < .001) more exacerbations per year, respectively, than those without. Patients with nasal polyposis and chronic rhinosinusitis were 40% and 46% more likely (P < .001), respectively, to have received long-term (LT) OCS. All assessed potential OCS-related comorbidities (except obesity) were associated with a greater likelihood of LTOCS use (odds ratios [ORs]: 1.23-2.77) and, except for dyslipidemia, with a greater likelihood of uncontrolled asthma (ORs: 1.29-1.68). All mimicking or aggravating comorbidities assessed were associated with more exacerbations (1.24-1.68 times more), all (except bronchiectasis) with increased likelihood of uncontrolled asthma (ORs: 1.57-1.81), and all (except chronic obstructive pulmonary ... |
| Document Type: | article in journal/newspaper |
| Language: | English |
| Relation: | Annals of Allergy, Asthma and Immunology 132 (1), 42-53; https://hdl.handle.net/10818/59790 |
| DOI: | 10.1016/j.anai.2023.08.021 |
| Availability: | https://hdl.handle.net/10818/59790; https://www.scopus.com/inward/record.uri?eid=2-s2.0-85174415775&doi=10.1016%2fj.anai.2023.08.021&partnerID=40&md5=f40fd26e90febfd35fcc8eb28bf0be58; https://doi.org/10.1016/j.anai.2023.08.021 |
| Rights: | Attribution-NonCommercial-NoDerivatives 4.0 International ; http://creativecommons.org/licenses/by-nc-nd/4.0/ ; openAccess |
| Accession Number: | edsbas.B57FA399 |
| Database: | BASE |