Selenium supplementation in individuals with newly diagnosed Graves’ hyperthyroidism:a double-blind, multi-centre RCT
| Title: | Selenium supplementation in individuals with newly diagnosed Graves’ hyperthyroidism:a double-blind, multi-centre RCT |
|---|---|
| Authors: | Cramon, Per K.; Winther, Kristian H.; Boesen, Victor B.; Larsen, Camilla B.; Bjorner, Jakob B.; Nordqvist, Selma F.; Forman, Julie L.; Juul, Anne B.; Bach-Mortensen, Pernille; Knudsen, Nils; Nolsøe, Runa L.; Vilsbøll, Tina; Andries, Alin; Gram, Jeppe; Nygaard, Birte; Demircan, Kamil; Chillon, Thilo S.; Schomburg, Lutz; Hegedüs, Laszlo; Bonnema, Steen J.; Feldt-Rasmussen, Ulla; Rasmussen, Åse K.; Watt, Torquil |
| Source: | Cramon, P K, Winther, K H, Boesen, V B, Larsen, C B, Bjorner, J B, Nordqvist, S F, Forman, J L, Juul, A B, Bach-Mortensen, P, Knudsen, N, Nolsøe, R L, Vilsbøll, T, Andries, A, Gram, J, Nygaard, B, Demircan, K, Chillon, T S, Schomburg, L, Hegedüs, L, Bonnema, S J, Feldt-Rasmussen, U, Rasmussen, Å K & Watt, T 2026, 'Selenium supplementation in individuals with newly diagnosed Graves’ hyperthyroidism : a double-blind, multi-centre RCT', European Thyroid Journal, vol. 15, no. 1, ETJ250264. https://doi.org/10.1530/ETJ-25-0264 |
| Publication Year: | 2026 |
| Collection: | University of Southern Denmark: Research Output / Syddansk Universitet |
| Subject Terms: | Graves’ disease; Graves’ hyperthyroidism; pragmatic trial; quality of life; selenium; ThyPRO |
| Description: | Purpose: We examined the effect of selenium vs placebo on remission rate and quality of life (QoL) in the Graves’ selenium supplementation (GRASS) trial (ID: NCT01611896). Methods: Double-blinded, placebo-controlled, multi-centre trial in individuals with newly diagnosed Graves’ hyperthyroidism randomised to daily supplementation with 200 μg selenium or placebo tablets during 24–30 months, depending on the timing of antithyroid drug (ATD) withdrawal. The primary outcome was the proportion of participants with non-remission, defined as receiving ATD or remaining hyperthyroid (thyroid stimulating hormone |
| Document Type: | article in journal/newspaper |
| File Description: | application/pdf |
| Language: | English |
| ISSN: | 2235-0640; 2235-0802 |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/41384622; info:eu-repo/semantics/altIdentifier/pissn/2235-0640; info:eu-repo/semantics/altIdentifier/eissn/2235-0802 |
| DOI: | 10.1530/ETJ-25-0264 |
| Availability: | https://portal.findresearcher.sdu.dk/da/publications/0a78472b-e532-4391-be81-faecccaca72f; https://doi.org/10.1530/ETJ-25-0264; https://findresearcher.sdu.dk/ws/files/304917551/etj-ETJ-25-0264.pdf |
| Rights: | info:eu-repo/semantics/openAccess ; http://creativecommons.org/licenses/by/4.0/ |
| Accession Number: | edsbas.B5AD0559 |
| Database: | BASE |