| Title: |
Omega-3 Fatty Acids Interact with DPP10 Region Genotype in Association with Childhood Atopy |
| Authors: |
Kathleen A. Lee-Sarwar; Kasper Fischer-Rasmussen; Klaus Bønnelykke; Hans Bisgaard; Bo Chawes; Rachel S. Kelly; Jessica Lasky-Su; Robert S. Zeiger; George T. O’Connor; Leonard B. Bacharier; Vincent J. Carey; Nancy Laranjo; Augusto A. Litonjua; Scott T. Weiss |
| Source: |
Nutrients, Vol 15, Iss 10, p 2416 (2023) |
| Publisher Information: |
MDPI AG |
| Publication Year: |
2023 |
| Collection: |
Directory of Open Access Journals: DOAJ Articles |
| Subject Terms: |
omega-3; polyunsaturated fatty acids; asthma; allergy; genotype; Nutrition. Foods and food supply; TX341-641 |
| Description: |
Associations of omega-3 fatty acids ( n -3) with allergic diseases are inconsistent, perhaps in part due to genetic variation. We sought to identify and validate genetic variants that modify associations of n -3 with childhood asthma or atopy in participants in the Vitamin D Antenatal Asthma Reduction Trial (VDAART) and the Copenhagen Prospective Studies on Asthma in Childhood 2010 (COPSAC). Dietary n -3 was derived from food frequency questionnaires and plasma n -3 was measured via untargeted mass spectrometry in early childhood and children aged 6 years old. Interactions of genotype with n -3 in association with asthma or atopy at age 6 years were sought for six candidate genes/gene regions and genome-wide. Two SNPs in the region of DPP10 (rs958457 and rs1516311) interacted with plasma n -3 at age 3 years in VDAART ( p = 0.007 and 0.003, respectively) and with plasma n -3 at age 18 months in COPSAC ( p = 0.01 and 0.02, respectively) in associationwith atopy. Another DPP10 region SNP, rs1367180, interacted with dietary n -3 at age 6 years in VDAART ( p = 0.009) and with plasma n -3 at age 6 years in COPSAC ( p = 0.004) in association with atopy. No replicated interactions were identified for asthma. The effect of n -3 on reducing childhood allergic disease may differ by individual factors, including genetic variation in the DPP10 region. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
https://www.mdpi.com/2072-6643/15/10/2416; https://doaj.org/toc/2072-6643; https://doaj.org/article/bec748d0ec7d4da98d01bb7e23fe64e7 |
| DOI: |
10.3390/nu15102416 |
| Availability: |
https://doi.org/10.3390/nu15102416; https://doaj.org/article/bec748d0ec7d4da98d01bb7e23fe64e7 |
| Accession Number: |
edsbas.B6546DD0 |
| Database: |
BASE |