| Title: |
Telomere length is correlated with mitochondrial DNA copy number in intestinal, but not diffuse, gastric cancer |
| Authors: |
SOO-JUNG JUNG; JI-HYOUNG CHO; WON‑JIN PARK; YU-RAN HEO; JAE-HO LEE |
| Contributors: |
조지형; Cho, Ji Hyoung; Dept. of Surgery (외과학) |
| Publisher Information: |
School of Medicine (의과대학) |
| Publication Year: |
2017 |
| Collection: |
Keimyung University Medical Library: KUMeL Repository |
| Subject Terms: |
diffuse type; gastric cancer; intestinal type; mitochondria DNA copy number; telomere |
| Description: |
A positive correlation between telomere length and mitochondrial DNA (mtDNA) copy number has previously been observed in healthy individuals, and in patients with psychiatric disorders. In the present study, telomere length and mtDNA copy number were evaluated in gastric cancer (GC) tissue samples. DNA was extracted from 109 GC samples (including 82 intestinal, and 27 diffuse cases), and the telomere length and mtDNA copy number were analyzed using a quantitative-polymerase chain reaction assay. The relative telomere length and mtDNA copy number in tumor tissue, as compared with in normal tissue, (mean ± standard deviation) in all GC samples were 11.48±1.14 and 14.86±1.35, respectively. Telomere length and mtDNA copy number were not identified as exhibiting clinical or prognostic value for GC. However, positive correlations between telomere length and mitochondrial DNA copy number were identified in GC (r=0.408, P |
| Document Type: |
article in journal/newspaper |
| Language: |
unknown |
| ISSN: |
1792-1074 |
| Relation: |
Oncology Letters, Vol.14(1) : 925-929, 2017; oak-2018-1080; http://kumel.medlib.dsmc.or.kr/handle/2015.oak/41497 |
| DOI: |
10.3892/ol.2017.6197 |
| Availability: |
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/41497; https://doi.org/10.3892/ol.2017.6197 |
| Rights: |
BY_NC_ND ; http://creativecommons.org/licenses/by-nc-nd/2.0/kr |
| Accession Number: |
edsbas.B69ADDF8 |
| Database: |
BASE |