| Title: |
Treated and untreated maternal prenatal mental health difficulties and neurodevelopmental outcomes in early childhood: results from the ELFE cohort |
| Authors: |
Marr, Ketevan; Barry, Katharine; Waerden, Judith van Der; Gomajee, Alexandre Ramchandar; Gressier, Florence; Dray-Spira, Rosemary; Dubertret, Caroline; Melchior, Maria; Sutter-Dallay, Anne-Laure; Dufourg, Marie‐noëlle; Charles, Marie-Aline |
| Contributors: |
Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP); Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU); Université de Rennes (UR); Institut de recherche en santé, environnement et travail (Irset); Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes (Biosit : Biologie - Santé - Innovation Technologique); École des Hautes Études en Santé Publique (EHESP); Département Méthodes quantitatives en santé publique (METIS); Faculté de Médecine Paris-Saclay; Hôpital Bicêtre AP-HP, Le Kremlin-Bicêtre; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris-Saclay; Agence nationale de sécurité du médicament et des produits de santé Saint-Denis (ANSM); Hôpital Paul Brousse; AP-HP. Université Paris Saclay; Bordeaux population health (BPH); Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM); Institut national d'études démographiques (INED) |
| Source: |
https://hal.science/hal-05326658 ; 2025. |
| Publisher Information: |
CCSD |
| Publication Year: |
2025 |
| Subject Terms: |
antenatal; care; epidemiology; paediatric; perinatal; psychiatry; statistics; epidemiological surveys; [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie |
| Description: |
V1 under reviewSubmitted to BJOG: An International Journal of Obstetrics and Gynaecology ; Objective: To assess the impact of prenatal psychotropic medication use on children’s neurodevelopmental outcomes. Design: Prospective observational study Setting: Maternity clinics Population: ELFE birth cohort (N=18,329) children who were unexposed to maternal mental health difficulties during pregnancy (MHD) (n=15,519), exposed to MHD (n=1,980), or exposed to prenatal psychotropic use (PPU) (n=242) Methods: Mothers reported their MHD and PPU at birth and covariates were collected at birth, two months, and one year postpartum. Inverse probability weighting based on multinomial propensity scores adjusted for a wide range of perinatal, socioeconomic, partner and healthcare system support, and family history confounders. Potential moderation by child sex, maternal education, and migration background was tested. Main Outcomes: Child Autistic traits were evaluated at 2 years using the Modified Checklist for Autism in Toddlers (M-CHAT) and general development at ages 3.5 and 5.5 years was evaluated using the Child Development Inventory (CDI). Results: PPU exposure was not associated with children’s M-CHAT, while MHD Exposure without PPU was significantly associated in both crude and weighted regressions. At 3.5 years, crude models showed lower CDI scores for children of MHD Exposed and PPU-exposed mothers compared with unexposed children, but all associations became non-significant after weighting. No significant effects, across CDI subscales, were observed at age 5.5 years, nor in moderation analyses. E-values suggested results were highly sensitive to residual confounding. Conclusions: We found limited evidence for clinically meaningful associations between prenatal psychotropic medication exposure and early child neurodevelopment after accounting for various maternal, household, socio-economic, and family history confounders. |
| Document Type: |
report |
| Language: |
English |
| DOI: |
10.22541/au.175880722.20436256/v1 |
| Availability: |
https://hal.science/hal-05326658; https://doi.org/10.22541/au.175880722.20436256/v1 |
| Accession Number: |
edsbas.B6A6FEFD |
| Database: |
BASE |