| Title: |
Small Split Doses of CD34 + Peripheral Blood Stem Cells to Support Repeated Cycles of Nonmyeloablative Chemotherapy |
| Authors: |
Yankelevich, Maxim; Savasan, Sureyya; Dolgopolov, Igor; Chu, Roland; Mentkevich, George |
| Source: |
Case Reports in Oncological Medicine ; volume 2017, page 1-4 ; ISSN 2090-6706 2090-6714 |
| Publisher Information: |
Wiley |
| Publication Year: |
2017 |
| Collection: |
Wiley Online Library (Open Access Articles via Crossref) |
| Description: |
Cumulative myelosuppression is the main limiting factor for administration of repeated cycles of chemotherapy. We present a case series of five pediatric patients with high-risk solid malignancies who received small split peripheral blood stem cells (PBSC) doses of less than 1 × 10 6 /kg CD34 + cells obtained after a single leukapheresis procedure and given after repeated cycles of ICE (ifosfamide, carboplatin, and etoposide) chemotherapy. Mean duration to absolute neutrophil count (ANC) recovery to >1000/mm 3 and platelet recovery to >50 × 10 3 /mm 3 was 17.1 and 24.3 days. Using split doses of PBSC prevented prolonged neutropenia after repeated cycles of submyeloablative chemotherapy. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1155/2017/4184879 |
| Availability: |
https://doi.org/10.1155/2017/4184879; http://downloads.hindawi.com/journals/crionm/2017/4184879.pdf; http://downloads.hindawi.com/journals/crionm/2017/4184879.xml |
| Rights: |
http://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.B6AB11DB |
| Database: |
BASE |