Sacubitril/Valsartan in Pediatric Heart Failure (PANORAMA-HF): A Randomized, Multicenter, Double-Blind Trial
| Title: | Sacubitril/Valsartan in Pediatric Heart Failure (PANORAMA-HF): A Randomized, Multicenter, Double-Blind Trial |
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| Authors: | Shaddy R.; Burch M.; Kantor P. F.; Solar-Yohay S.; Garito T.; Zhang S.; Kocun M.; Mao C.; Cilliers A.; Wang X.; Canter C.; Rossano J.; Wallis G.; Menteer J.; Daou L.; Kusa J.; Tokel K.; Dilber D.; Xu Z.; Xiao T.; Halnon N.; Daly K. P.; Bock M. J.; Zuckerman W.; Singh T. P.; Chakrabarti M.; Levitas A.; Senni M.; Grutter G.; Kim G. B.; Song J.; Lee H. D.; Chen C. K.; Sanchez-De-Toledo J.; Law Y.; Wanitkun S.; Cui Y.; Anjos R.; Mese T.; Bonnet D.; Ablonczy L.; Aggarwal N.; Agnoletti G.; Alhabdan M.; Amedro P.; Ameduri R.; Alberto Annoni G.; Asante-Korang A.; Audi N.; Ballweg J.; Berger F.; Bosaleh M.; Boyle G.; Castaldi B.; Chag M.; Chaloupecky V.; Chehab G.; Conway J.; Daehnert I.; Di Bernardo S.; Dittrich S.; Dogan E.; Donti A.; Durongpisitkul K.; Favilli S.; Feingold B.; Garcia-Guereta L.; Gil-Villanueva N.; Glass L.; Gomez-Guzman E.; Gorenflo M.; Gran F.; Hirata Y.; Hirono K.; Hoshino K.; Hsieh K. S.; Hussain M.; Inuzuka R.; Ishido M.; Jeewa A.; Johnson J.; Jokinen E.; Won Jung J.; Kaneva-Nencheva A.; Kaufman B.; Kochilas L.; Kumar S.; Lal A.; Viktorovna Leontyeva I.; Lin I. C.; Lytrivi I.; Malcic I.; Marinho Da Silva A.; Medrano Lopez C.; Milanesi O.; Deanne Miyamoto S.; Motomura H.; Odri Komazec I.; Ono H.; Pacileo G. |
| Contributors: | Shaddy, R.; Burch, M.; Kantor, P. F.; Solar-Yohay, S.; Garito, T.; Zhang, S.; Kocun, M.; Mao, C.; Cilliers, A.; Wang, X.; Canter, C.; Rossano, J.; Wallis, G.; Menteer, J.; Daou, L.; Kusa, J.; Tokel, K.; Dilber, D.; Xu, Z.; Xiao, T.; Halnon, N.; Daly, K. P.; Bock, M. J.; Zuckerman, W.; Singh, T. P.; Chakrabarti, M.; Levitas, A.; Senni, M.; Grutter, G.; Kim, G. B.; Song, J.; Lee, H. D.; Chen, C. K.; Sanchez-De-Toledo, J.; Law, Y.; Wanitkun, S.; Cui, Y.; Anjos, R.; Mese, T.; Bonnet, D.; Ablonczy, L.; Aggarwal, N.; Agnoletti, G.; Alhabdan, M.; Amedro, P.; Ameduri, R.; Alberto Annoni, G.; Asante-Korang, A.; Audi, N.; Ballweg, J.; Berger, F.; Bosaleh, M.; Boyle, G.; Castaldi, B.; Chag, M.; Chaloupecky, V.; Chehab, G.; Conway, J.; Daehnert, I.; Di Bernardo, S.; Dittrich, S.; Dogan, E.; Donti, A.; Durongpisitkul, K.; Favilli, S.; Feingold, B.; Garcia-Guereta, L.; Gil-Villanueva, N.; Glass, L.; Gomez-Guzman, E.; Gorenflo, M.; Gran, F.; Hirata, Y.; Hirono, K.; Hoshino, K.; Hsieh, K. S.; Hussain, M.; Inuzuka, R.; Ishido, M.; Jeewa, A.; Johnson, J.; Jokinen, E.; Won Jung, J.; Kaneva-Nencheva, A.; Kaufman, B.; Kochilas, L.; Kumar, S.; Lal, A.; Viktorovna Leontyeva, I.; Lin, I. C.; Lytrivi, I.; Malcic, I.; Marinho Da Silva, A.; Medrano Lopez, C.; Milanesi, O.; Deanne Miyamoto, S.; Motomura, H.; Odri Komazec, I.; Ono, H.; Pacileo, G. |
| Publisher Information: | LIPPINCOTT WILLIAMS & WILKINS |
| Publication Year: | 2024 |
| Collection: | Padua Research Archive (IRIS - Università degli Studi di Padova) |
| Subject Terms: | enalapril; heart failure; valsartan; ventricular dysfunction; left |
| Description: | BACKGROUND:Sacubitril/valsartan, an angiotensin receptor-neprilysin inhibitor (ARNI), is an established treatment for heart failure (HF) with reduced left ventricular ejection fraction. It has not been rigorously compared with angiotensin-converting enzyme inhibitors in children. PANORAMA-HF (Prospective Trial to Assess the Angiotensin Receptor Blocker Neprilysin Inhibitor LCZ696 Versus Angiotensin-Converting Enzyme Inhibitor for the Medical Treatment of Pediatric HF) is a randomized, double-blind trial that evaluated the pharmacokinetics and pharmacodynamics (PK/PD), safety, and efficacy of sacubitril/valsartan versus enalapril in children 1 month to |
| Document Type: | article in journal/newspaper |
| Language: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/39319469; info:eu-repo/semantics/altIdentifier/wos/WOS:001361409700006; volume:150; issue:22; firstpage:1756; lastpage:1766; numberofpages:11; journal:CIRCULATION; https://hdl.handle.net/11577/3548826 |
| DOI: | 10.1161/CIRCULATIONAHA.123.066605 |
| Availability: | https://hdl.handle.net/11577/3548826; https://doi.org/10.1161/CIRCULATIONAHA.123.066605 |
| Rights: | info:eu-repo/semantics/openAccess ; license:Creative commons ; license uri:http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Accession Number: | edsbas.B6AC302C |
| Database: | BASE |