| Title: |
RADIOLOGY |
| Authors: |
Bluml, Stefan; Panigrahy, Ashok; Laskov, Mikhail; Dhall, Girish; Nelson, Marvin D.; Finlay, Jonathan L.; Gilles, Floyd H.; Arita, Hideyuki; Kinoshita, Manabu; Kagawa, Naoki; Fujimoto, Yasunori; Hashimoto, Naoya; Yoshimine, Toshiki; Hamilton, Jackson D.; Wang, Jihong; Levin, Victor A.; Hou, Ping; Loghin, Monica E.; Gilbert, Mark R.; Leeds, Norman E.; deGroot, John F.; Puduvalli, Vinay; Jackson, Edward F.; Yung, W.K.A.; Kumar, Ashok J.; Ellingson, Benjamin M.; Cloughesy, Timothy F.; Pope, Whitney B.; Zaw, Taryar; Phillips, Heidi; Lalezari, Shadi; Nghiemphu, Phioanh L.; Ibrahim, Hassana; Motevalibashinaeini, Korosh; Lai, Albert; Harris, Robert; Douw, Linda; Van de Nieuwenhuijzen, Marieke E.; Heimans, Jan J.; Baayen, Johannes C.; Stam, Cornelis J.; Reijneveld, Jaap C.; Juhasz, Csaba; Mittal, Sandeep; Altinok, Deniz; Robinette, Natasha L.; Muzik, Otto; Chakraborty, Pulak K.; Barger, Geoffrey R.; Zaw, Taryar M.; Goldin, Jonathan; Chen, Wei; Ahlman, Mark A.; Giglio, Pierre; Kaufmann, Timothy J.; Anderson, S. Keith; Jaeckle, Kurt A.; Uhm, Joon H.; Northfelt, Donald W.; Flynn, Patrick J.; Buckner, Jann C.; Galanis, Eva; Zalatimo, Omar; Weston, Cody; Allison, Dana; Bota, Daniela; Kesari, Santosh; Glantz, Michael; Sheehan, Jonas; Harbaugh, Robert E.; Chiba, Yasuyoshi; Tsuboi, Akihiro; Hatazawa, Jun; Sugiyama, Haruo; Nariai, Tadashi; Toyohara, Jun; Tanaka, Yoji; Inaji, Motoki; Aoyagi, Masaru; Yamamoto, Masaaki; Ishiwara, Kiichi; Ohno, Kikuo; Jalilian, Laleh; Essock-Burns, Emma; Cha, Soonmee; Chang, Susan; Prados, Michael; Butowski, Nicholas; Nelson, Sarah; Kawahara, Yosuke; Nakada, Mitsutoshi; Hayashi, Yutaka; Kai, Yutaka; Hayashi, Yasuhiko; Uchiyama, Naoyuki; Kuratsu, Jun-ichi; Hamada, Jun-ichiro; Yeom, Kristen; Rosenberg, Jarrett; Andre, Jalal B.; Fisher, Paul G.; Edwards, Michael S.; Barnes, Patrick D.; Partap, Sonia; Lupo, Janine M.; Crane, Jason C.; Chang, Susan M.; Nelson, Sarah J.; Romanowski, Charles A.; Hoggard, Nigel; Jellinek, David A.; Clenton, Susan; McKevitt, Fiona; Wharton, Stephen; Craven, Ian; Buller, Ashley; Waddle, Cheryl; Bigley, Julia; Wilkinson, Iain D.; Metherall, Peter; Eckel, Laurence J.; Keating, Gesina F.; Wetjen, Nicholas M.; Giannini, Caterina; Wetmore, Cynthia; Jain, Rajan; Narang, Jayant; Arbab, Ali Syed; Schultz, Lonni; Scarpace, Lisa; Mikkelsen, Tom; Babajni-Feremi, Abbas; Poisson, Laila; Gutman, David; Jaffe, Carl; Saltz, Joel; Flanders, Adam; Daniel, Brat; Zach, Leor; Guez, David; Last, David; Daniels, Dianne; Hoffman, Chen; Mardor, Yael; Guha-Thakurta, Nandita; Debnam, J.M.; Kotsarini, Christina; Jellinek, David; Griffiths, Paul D.; Khandanpour, Nader; Bambrough, Paul; Prabhu, Sujit; Bassett, Roland L.; Yung, WK.A.; Campen, Cynthia J.; Soman, Salil; Yeom, Kristen W.; Vos, Maaike J.; Berkhof, Johannes; Postma, Tjeerd J.; Sanchez, Esther; Sizoo, Eefje M.; Lagerwaard, Frank J.; Buter, Jan; Noske, David P.; Colen, Rivka R.; Mahajan, Bhanu; Jolesz, Ferenc A.; Zinn, Pascal O.; Molinaro, Annette; Lawton, Kristen; Alexandru, Daniela; Linskey, Mark E.; Chaumeil, Myriam M.; Gini, Beatrice; Yang, Huijan; Iwanami, Akio; Subramanian, Sukumar; Ozawa, Tomoko; Read, Elizabeth J.; Pieper, Russel O.; Mischel, Paul; James, C.D.; Ronen, Sabrina M.; LaViolette, Peter S.; Cochran, Elizabeth; Al-Gizawiy, Mona; Connelly, Jennifer M.; Malkin, Mark G.; Rand, Scott D.; Mueller, Wade M.; Schmainda, Kathleen M.; Cohen, Alex D.; Prah, Melissa; Hartman, Cory J.; Qiao, Xin J.; He, Ren; Brown, Matthew; Cloughesy, Timothy |
| Publisher Information: |
Oxford University Press |
| Publication Year: |
2011 |
| Collection: |
HighWire Press (Stanford University) |
| Subject Terms: |
Abstracts |
| Description: |
In vivo MR spectroscopy (MRS) provides information about metabolite concentrations in tissue. Recently, citrate (Cit) was detected by MRS in subgroups of pediatric brain tumors. Citrate is an intermediate in the tricarboxylic acid (TCA) cycle and accumulates in tissue when the glycolytic rate exceeds the TCA cycle activity, a feature of malignant tumors. Currently, no practical indicators allow clinicians to predict risk for malignant progression of pediatric astrocytomas (WHO grade II). Medical records and citrate concentrations measured with in vivo MRS of 29 pediatric astrocytomas were reviewed. This included six astrocytomas (WHO grade II) with stable disease (indolent-LGA) for more than 2 years and 7 aggressive grade II astrocytomas (aggressive-LGA), 13 anaplastic astrocytomas (WHO grade III), and 3 glioblastomas (WHO grade IV) with disease progression within 2 years. Citrate was observed in all aggressive-LGA, and the mean citrate concentration was significantly higher in this group than in indolent-LGA (4.1 ± 1.1 vs 0.6 ± 0.8 mmol/kg; P < 0.0001). There was no consistent pattern for citrate in anaplastic astrocytoma and glioblastoma, with citrate prominent in some lesions while undetectable in others. It is unclear whether citrate accumulation occurred due to fundamental defects of citrate regulation, such as isocitrate dehydrogenase mutations, or secondary to altered physiological conditions. Nonetheless, prominent citrate identified a subgroup of pediatric grade II astrocytomas destined for aggressive behavior. Citrate was not specific for poor outcome as it was not detectable in all high-grade astrocytomas. Among high-grade astrocytoma, tumors with prominent citrate may constitute a metabolic subclass. |
| Document Type: |
text |
| File Description: |
text/html |
| Language: |
English |
| Relation: |
http://neuro-oncology.oxfordjournals.org/cgi/content/short/13/suppl_3/iii136; http://dx.doi.org/10.1093/neuonc/nor162 |
| DOI: |
10.1093/neuonc/nor162 |
| Availability: |
http://neuro-oncology.oxfordjournals.org/cgi/content/short/13/suppl_3/iii136; https://doi.org/10.1093/neuonc/nor162 |
| Rights: |
Copyright (C) 2011, Society for Neuro-Oncology (SNO) |
| Accession Number: |
edsbas.B6D61226 |
| Database: |
BASE |