Development and validation of a scoring system to predict response to obeticholic acid in primary biliary cholangitis
| Title: | Development and validation of a scoring system to predict response to obeticholic acid in primary biliary cholangitis |
|---|---|
| Authors: | De Vincentis A; Ampuero J; Terracciani F; D'Amato D; Gerussi A; Cristoferi L; Cazzagon N; Bonaiuto E; Floreani A; Calvaruso V; Cadamuro L; Degasperi E; Morgando A; Vanni E; Lleo A; Colapietro F; Alvaro D; Castellaneta A; Labanca S; Viganò M; Distefano M; Pace Palitti V; Ricci C; De Matthaeis N; Marzioni M; Gómez-Dominguez E; Montero JL; Molina E; Garcia-Buey L; Casado M; Berenguer M; Conde I; Simon MA; Fuentes J; Costa-Moreira P; Macedo G; Jorquera F; Morillas RM; Presa J; Sousa JM; Gomes D; Santos L; Olveira A; Hernandez-Guerra M; Aburruza L; Santos A; Carvalho A; Uriz J; Gutierrez ML; Perez E; Chessa L; Pellicelli A; Marignani M; Muratori L; Niro GA; Brunetto M; Ponziani FR; Pompili M; Marra F; Galli A; Mussetto A; Alagna G; Simone L; Bertino G; Rosina F; Cozzolongo R; Russello M; Saitta C; Terreni N; Zolfino T; Rigamonti C; Vigano R; Cuccorese G; Pozzoni P; Pedone C; Grasso S; Picardi A; Invernizzi P; Sacco R; Izzi A; Fernandez-Rodriguez C; Vespasiani-Gentilucci U; Carbone M; Baiocchi L |
| Contributors: | De Vincentis A; Ampuero J; Terracciani F; D'Amato D; Gerussi A; Cristoferi L; Cazzagon N; Bonaiuto E; Floreani A; Calvaruso V; Cadamuro L; Degasperi E; Morgando A; Vanni E; Lleo A; Colapietro F; Alvaro D; Castellaneta A; Labanca S; Viganò, M; Distefano M; Pace Palitti V; Ricci C; De Matthaeis N; Marzioni M; Gómez-Dominguez E; Montero Jl; Molina E; Garcia-Buey L; Casado M; Berenguer M; Conde I; Simon Ma; Fuentes J; Costa-Moreira P; Macedo G; Jorquera F; Morillas Rm; Presa J; Sousa Jm; Gomes D; Santos L; Olveira A; Hernandez-Guerra M; Aburruza L; Santos A; Carvalho A; Uriz J; Gutierrez Ml; Perez E; Chessa L; Pellicelli A; Marignani M; Muratori L; Niro Ga; Brunetto M; Ponziani Fr; Pompili M; Marra F; Galli A; Mussetto A; Alagna G; Simone L; Bertino G; Rosina F; Cozzolongo R; Russello M; Saitta C; Terreni N; Zolfino T; Rigamonti C; Vigano R; Cuccorese G; Pozzoni P; Pedone C; Grasso S; Picardi A; Invernizzi P; Sacco R; Izzi A; Fernandez-Rodriguez C; Vespasiani-Gentilucci U; Carbone M; Baiocchi L |
| Publication Year: | 2024 |
| Collection: | Università degli Studi di Brescia: OPENBS - Open Archive UniBS |
| Subject Terms: | Obeticholic Acid; Predictive Model; Primary Biliary Cholangitis |
| Description: | Background & aims: Obeticholic acid (OCA) is the only licensed second-line therapy for primary biliary cholangitis (PBC). With novel therapeutics in advanced development, clinical tools are needed to tailor the treatment algorithm. We aimed to derive and externally validate the OCA response score (ORS) for predicting the response probability of individuals with PBC to OCA. Methods: We used data from the Italian RECAPITULATE (N = 441) and the IBER-PBC (N = 244) OCA real-world prospective cohorts to derive/validate a score including widely available variables obtained either pre-treatment (ORS) or also after 6 months of treatment (ORS+). Multivariable Cox regressions with backward selection were applied to obtain parsimonious predictive models. The predicted outcomes were biochemical response according to POISE (alkaline phosphatase [ALP]/upper limit of normal [ULN] |
| Document Type: | article in journal/newspaper |
| File Description: | ELETTRONICO |
| Language: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/38782175; info:eu-repo/semantics/altIdentifier/wos/WOS:001381360500001; volume:22; firstpage:2062; lastpage:2074; numberofpages:13; journal:CLINICAL GASTROENTEROLOGY AND HEPATOLOGY; https://hdl.handle.net/11379/614437 |
| DOI: | 10.1016/j.cgh.2024.05.008 |
| Availability: | https://hdl.handle.net/11379/614437; https://doi.org/10.1016/j.cgh.2024.05.008 |
| Rights: | info:eu-repo/semantics/openAccess |
| Accession Number: | edsbas.B6DB3367 |
| Database: | BASE |