| Title: |
Development of a novel biomarker of free radical damage in reperfusion injury after cardiac arrest |
| Authors: |
Basu, S.; Nozari, A.; Liu, X.L.; Rubertsson, S.; Wiklund, L. |
| Source: |
FEBS Letters ; volume 470, issue 1, page 1-6 ; ISSN 0014-5793 1873-3468 |
| Publisher Information: |
Wiley |
| Publication Year: |
2000 |
| Collection: |
Wiley Online Library (Open Access Articles via Crossref) |
| Description: |
In a porcine model of cardiopulmonary resuscitation (CPR), we investigated changes in the plasma levels of 8‐iso‐PGF 2α , a marker for oxidative injury, and 15‐keto‐dihydro‐PGF 2α , an inflammatory response indicator during the post‐resuscitation period after cardiac arrest. Twelve piglets were subjected to either 2 or 5 min (VF2 and VF5 group) of ventricular fibrillation (VF) followed by 5 min of closed‐chest CPR. Six piglets without cardiac arrest were used as controls. In VF5 group, 8‐iso‐PGF 2α in the jugular bulb plasma (draining the brain) increased four‐fold. Jugular bulb 8‐iso‐PGF 2α in the control group remained unchanged. The 15‐keto‐dihydro‐PGF 2α also increased four‐fold in the VF5 group. Thus, 8‐iso‐PGF 2α and 15‐keto‐dihydro‐PGF 2α measurements in jugular bulb plasma may be used as biomarkers for quantification of free radical catalyzed oxidative brain injury and inflammatory response in reperfusion injury. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1016/s0014-5793(00)01279-5 |
| DOI: |
10.1016/S0014-5793%2800%2901279-5 |
| Availability: |
https://doi.org/10.1016/s0014-5793(00)01279-5; https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1016%2FS0014-5793%2800%2901279-5; https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1016%2FS0014-5793(00)01279-5; https://febs.onlinelibrary.wiley.com/doi/pdf/10.1016/S0014-5793%2800%2901279-5 |
| Rights: |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
| Accession Number: |
edsbas.B7015800 |
| Database: |
BASE |