| Title: |
Dispersals and genetic adaptation of Bantu-speaking populations in Africa and North America. |
| Authors: |
Patin, Etienne; Lopez, Marie; Grollemund, Rebecca; Verdu, Paul; Harmant, Christine; Quach, Hélène; Laval, Guillaume; Perry, George; Barreiro, Luis; Froment, Alain; Heyer, Evelyne; Massougbodji, Achille; Fortes-Lima, Cesar; Migot-Nabias, Florence; Bellis, Gil; Dugoujon, Jean-Michel; Pereira, Joana; Fernandes, Verónica; Pereira, Luisa; van Der Veen, Lolke; Mouguiama-Daouda, Patrick; Bustamante, Carlos, D.; Hombert, Jean-Marie; Quintana-Murci, Lluis |
| Contributors: |
Génétique Evolutive Humaine - Human Evolutionary Genetics; Institut Pasteur Paris (IP)-Centre National de la Recherche Scientifique (CNRS); Centre de Bioinformatique, Biostatistique et Biologie Intégrative (C3BI); Eco-Anthropologie et Ethnobiologie (EAE); Muséum national d'Histoire naturelle (MNHN)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS); parasitology and mycology education; Science and health faculty; Mère et enfant en milieu tropical : pathogènes, système de santé et transition épidémiologique (MERIT - UMR_D 216); Institut de Recherche pour le Développement (IRD)-Université Paris Descartes - Paris 5 (UPD5); Institut national d'études démographiques (INED); Anthropologie Moléculaire et Imagerie de Synthèse (AMIS); Université Toulouse III - Paul Sabatier (UT3); Communauté d'universités et établissements de Toulouse (Comue de Toulouse)-Communauté d'universités et établissements de Toulouse (Comue de Toulouse)-Centre National de la Recherche Scientifique (CNRS); Instituto de Investigação e Inovação em Saúde (I3S); Universidade do Porto = University of Porto; Dynamique Du Langage (DDL); Université Lumière - Lyon 2 (UL2)-Centre National de la Recherche Scientifique (CNRS); Affymetrix; This work was funded by the Institut Pasteur, the Centre National de la Recherche Scientifique (CNRS), Agence Nationale de la Recherche (ANR) grant AGRHUM (ANR-14-CE02-0003-01), and the “Histoire du Génome des Populations Humaines Gabonaises” project (Institut Pasteur/Republic of Gabon). The newly generated SNP genotype data have been deposited in the European Genome-Phenome Archive under accession code EGAS00001002078.; ANR-14-CE02-0003,AGRHUM,Etude de l'adaptation génétique aux changements environnementaux rapides : l'agriculture et le modèle humain(2014) |
| Source: |
ISSN: 0036-8075. |
| Publisher Information: |
CCSD; American Association for the Advancement of Science (AAAS) |
| Publication Year: |
2017 |
| Collection: |
Université Toulouse III - Paul Sabatier: HAL-UPS |
| Subject Terms: |
MESH: Adaptation; Physiological/genetics; MESH: Africa; Central; MESH: Speech; MESH: African Americans/genetics; MESH: Genetic Loci; MESH: HLA Antigens/genetics; MESH: Human Migration; MESH: Humans; MESH: Lactase/genetics; MESH: Language; MESH: North America; MESH: Polymorphism; Single Nucleotide; MESH: Rainforest; [SHS.ANTHRO-BIO]Humanities and Social Sciences/Biological anthropology; [SDV.GEN]Life Sciences [q-bio]/Genetics |
| Description: |
International audience ; Bantu languages are spoken by about 310 million Africans, yet the genetic history of Bantu-speaking populations remains largely unexplored. We generated genomic data for 1318 individuals from 35 populations in western central Africa, where Bantu languages originated. We found that early Bantu speakers first moved southward, through the equatorial rainforest, before spreading toward eastern and southern Africa. We also found that genetic adaptation of Bantu speakers was facilitated by admixture with local populations, particularly for the HLA and LCT loci. Finally, we identified a major contribution of western central African Bantu speakers to the ancestry of African Americans, whose genomes present no strong signals of natural selection. Together, these results highlight the contribution of Bantu-speaking peoples to the complex genetic history of Africans and African Americans. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/28473590; PUBMED: 28473590 |
| DOI: |
10.1126/science.aal1988 |
| Availability: |
https://hal.science/hal-02277558; https://doi.org/10.1126/science.aal1988 |
| Rights: |
https://about.hal.science/hal-authorisation-v1/ |
| Accession Number: |
edsbas.B75D4522 |
| Database: |
BASE |