| Title: |
Automatic measurement of short-term variability of repolarization captures modulation by pacing on human electrograms |
| Authors: |
Chiu, Cheyenne S.L.; Loen, Vera; Aranda Hernandez,Alfonso; Smoczyńska, Agnieszka; Sprenkeler, David J.; Tuinenburg, Anton E.; Scheerder,Coert O.S.; DeGroot,Paul J.; Vos, Marc A.; Meine, Mathias; Cardiologie; Onderzoek Device; Cardiovasculaire Fysiologie; Arts Assistenten Cardiologie; Team Medisch; Circulatory Health |
| Publication Year: |
2025 |
| Subject Terms: |
Automatic measurement; Electrogram; Implantable cardioverter-defibrillator; Pacing; Short-term variability of repolarization; Ventricular arrhythmias; Cardiology and Cardiovascular Medicine |
| Description: |
Background: Short-term variability of repolarization (STV) increases prior to ventricular arrhythmias in both humans and animal models, making it a promising tool for real-time arrhythmic risk monitoring. Objective: An automatic STV measurement algorithm was developed for intracardiac electrograms (EGMs) to enable integration into cardiac devices. This method previously demonstrated high accuracy in predicting life-threatening ventricular arrhythmias in animals. This study compared the performance of the automatic method to the gold standard on EGMs in humans. Methods: EGM signals were recorded in 14 patients with a dual-chamber implantable cardioverter-defibrillator during de novo implantation (n = 5) or replacement (n = 9) procedures. Recordings were obtained in sinus rhythm (SR), atrial pacing at 80 beats/min, and dual-chamber pacing at 80 beats/min. STV was determined on the EGM from the activation recovery interval with the automatic method (STV-ARIauto) and with fiducial segment averaging (STV-ARIFSA), the gold standard. STV-ARIauto was compared with STV-ARIFSA for all pacing modes. Results: STV-ARIauto and STV-ARIFSA decreased from 0.90 ± 0.51 ms and 0.99 ± 0.39 ms in SR (53 ± 9 beats/min) to 0.60 ± 0.37 ms (and 0.68 ± 0.39 ms in atrial pacing at 80 beats/min, and to 0.32 ± 0.15 ms and 0.59 ± 0.24 ms in dual-chamber pacing at 80 beats/min, respectively (all P |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| Relation: |
https://dspace.library.uu.nl/handle/1874/465896 |
| Availability: |
https://dspace.library.uu.nl/handle/1874/465896 |
| Rights: |
info:eu-repo/semantics/OpenAccess |
| Accession Number: |
edsbas.B7652634 |
| Database: |
BASE |