| Title: |
Impact of Total Thyroidectomy on Quality of Life at 6 Months: The Prospective ThyrQoL Multicentre Trial. |
| Authors: |
Mirallié, E; Borel, F; Trésallet, C; Hamy, A; Mathonnet, M; Lifante, Jc; Brunaud, L; Menégaux, F; Hardouin, Jean-Benoit; Blanchard, C; Ansquer, Catherine; Mourrain-Langlois, Emmanuelle; Delemazure, Anne Sophie; Perrot, Bastien; Longhi, Mylène; Nominé, Claire; Espitalier, Florent; Drui, Delphine; Caillard, Cécile; Renaud-Moreau, Nelly; Marret, Oliver; Mucci, Stéphanie; Christou, Niki; , |
| Contributors: |
Centre Hospitalier Universitaire de Nantes = Nantes University Hospital (CHU Nantes); CHU Pitié-Salpêtrière AP-HP; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU); Centre Hospitalier Universitaire d'Angers (CHU Angers); CHU Limoges; Centre Hospitalier Lyon Sud CHU - HCL (CHLS); Hospices Civils de Lyon (HCL); Centre Hospitalier Universitaire de Nancy (CHU Nancy); methodS in Patients-centered outcomes and HEalth ResEarch (SPHERE); Université de Tours (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR des Sciences Pharmaceutiques et Biologiques (UFR SPB); Université de Nantes (UN)-Université de Nantes (UN); Plateforme de Méthodologie et Biostatistique, Direction de la Recherche CHU Nantes; ITX - unité de recherche de l'institut du thorax (ITX); Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE); Université de Lorraine (UL); Département d'Endocrinologie CHU Nantes (Institut du Thorax); Centre Hospitalier Universitaire de Nantes = Nantes University Hospital (CHU Nantes)-Institut du Thorax CHU Nantes (CHU Thorax); Clinique de chirurgie digestive et endocrinienne; IMAD; Institut des maladies de l'appareil digestif Nantes (IMAD); Université d'Angers (UA); Service de Chirurgie digestive, endocrinienne et générale CHU Limoges; ANR-16-IDEX-0007,NExT (I-SITE),NExT (I-SITE)(2016) |
| Source: |
ISSN: 0804-4643. |
| Publisher Information: |
CCSD; Oxford Univ. Press |
| Publication Year: |
2020 |
| Collection: |
Université de Nantes: HAL-UNIV-NANTES |
| Subject Terms: |
Thyroidectomy; MESH: Adult; MESH: Female; MESH: Treatment Outcome; MESH: Humans; MESH: Male; MESH: Middle Aged; MESH: Postoperative Complications; MESH: Prospective Studies; MESH: Quality of Life; MESH: Thyroid Diseases; MESH: Thyroidectomy; [SDV]Life Sciences [q-bio] |
| Description: |
International audience ; Objective: This study is to determine the impact of complications after total thyroidectomy on health-related quality of life (HR-QoL) and to identify significant predictive factors of HR-QoL changes. HR-QoL is usually impaired in patients with thyroid diseases compared to the general population. Thyroidectomy is largely performed in the case of benign thyroid benign and can be associated with long-term complications (vocal cord palsy, hypoparathyroidism).Design: The prospective ThyrQoL multicenter trial (NCT02167529) included 800 patients who underwent total thyroidectomy for benign or malignant non-extensive disease in seven French referral hospitals between 2014 and 2016.Methods: HR-QoL was assessed using the MOS 36-item short form health survey (SF-36) self-questionnaire with a 6-month follow-up.Results: We observed a significant improvement of HR-QoL 6 months after surgery (P < 0.0001). Postoperative complications were associated with a non-significant impairment of HR-QoL. In multivariable analysis, Graves' disease was associated with a significant improvement of HR-QoL (OR = 2.39 [1.49; 3.84]) and thyroid malignant disease with an impairment of HR-QoL (OR = 1.44 [0.99; 2.08]) after thyroidectomy.Conclusion: We observed a significant improvement of HR-QoL 6 months after total thyroid surgery for benign thyroid disease. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/31804967; PUBMED: 31804967 |
| DOI: |
10.1530/EJE-19-0587 |
| Availability: |
https://hal.science/hal-03158817; https://doi.org/10.1530/EJE-19-0587 |
| Accession Number: |
edsbas.B77F491F |
| Database: |
BASE |