| Title: |
Anti-RNA polymerase III antibodies in systemic sclerosis: prevalence and clinical associations from a systematic review and meta-analysis. |
| Authors: |
Elhannani, Abderrahmane; Martel, Marie-Elise; Collet, Aurore; Chepy, Aurelien; Sanges, Sebastien; Hachulla, Eric; Dubucquoi, Sylvain; Launay, David; Sobanski, Vincent |
| Contributors: |
Institute for Translational Research in Inflammation - U 1286 (INFINITE); Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire CHU Lille (CHRU Lille); Centre Hospitalier Régional Universitaire CHU Lille (CHRU Lille); Centre de référence constitutif des maladies auto-immunes et auto inflammatoires rares du nord, Nord-Ouest, Méditerranée et Guadeloupe (CeRAINOM-Angers); Centre Hospitalier Universitaire d'Angers (CHU Angers); Université de Lille; Institut universitaire de France (IUF); Ministère de l'Education nationale, de l’Enseignement supérieur et de la Recherche (M.E.N.E.S.R.) |
| Source: |
ISSN: 1462-0324. |
| Publisher Information: |
CCSD; Oxford University Press (OUP) |
| Publication Year: |
2025 |
| Collection: |
LillOA (HAL Lille Open Archive, Université de Lille) |
| Subject Terms: |
autoantibodies; meta-analysis; prevalence; rna-polymerase; systematic review; systemic sclerosis; [SDV]Life Sciences [q-bio] |
| Description: |
International audience ; ObjectivesAnti-RNA polymerase III antibodies (ARA) are frequent in systemic sclerosis (SSc). However, the reported prevalence is variable among studies and some clinical associations are debated. We aimed (i) to update the recent data on overall ARA prevalence in SSc and heterogeneity between centers; and (ii) to describe their clinical associations.MethodsA systematic review of the literature available up to June 2024 was carried out in Pubmed and Embase. Meta-analyses were performed to assess the prevalence and clinical associations of ARA in SSc, combined with meta-regressions in case of heterogeneity to identify potential cofactors.ResultsNinety-three studies corresponding to a total of 23,038 SSc patients were included in the meta-analysis. In this population, the overall seroprevalence of ARA was 9% (95% confidence interval [CI]: 8-10) with a high degree of heterogeneity (I2 = 88%, p < 0.001). ARA positivity was significantly associated with diffuse cutaneous subset (OR: 2.20 [1.91-2.53]), joint manifestations (OR: 1.29 [1.01-1.66]), gastric antral vascular ectasia (GAVE) (OR: 2.70 [1.52-4.81]), heart involvement (OR: 1.93 [1.18-3.18]), scleroderma renal crisis (OR: 7.82 [5.79-10.57]), interstitial lung disease (ILD) (OR: 1.10 [1.00-1.20]), and cancer (OR: 1.86 [1.33-2.59]).ConclusionThis study provides an overall seroprevalence of ARA of 9% [8-10] and confirms that SSc patients with ARA are at higher risk of severe skin extension and renal crisis. It also highlights a positive association with cancer, GAVE, heart, joint involvement and ILD. ARA positive SSc patients could therefore benefit from an appropriate screening of these potentially severe complications. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/40676730; PUBMED: 40676730 |
| DOI: |
10.1093/rheumatology/keaf392 |
| Availability: |
https://hal.univ-lille.fr/hal-05303759; https://hal.univ-lille.fr/hal-05303759v1/document; https://hal.univ-lille.fr/hal-05303759v1/file/keaf392.pdf; https://doi.org/10.1093/rheumatology/keaf392 |
| Rights: |
http://creativecommons.org/licenses/by/ ; info:eu-repo/semantics/OpenAccess |
| Accession Number: |
edsbas.B79DC417 |
| Database: |
BASE |