| Title: |
Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy to treat pseudomyxoma peritonei of ovarian origin: A retrospective French RENAPE group study |
| Authors: |
Trecourt, Alexis; Bakrin, Naoual; Glehen, Olivier; Gertych, Witold; Villeneuve, Laurent; Isaac, Sylvie; Benzerdjeb, Nazim; Fontaine, Juliette; Genestie, Catherine; Dartigues, Peggy; Leroux, Agnès; Quenet, François; Marchal, Frederic; Odin, Cecile; Khellaf, Lakhdar; Svrcek, Magali; Thierry, Sixte; Augros, Marilyn; Omar, Alhadeedi; Devouassoux-Shisheboran, Mojgan; Kepenekian, Vahan; Abba, Julio; Abboud, Karine; Aimé, Adeline; Amroun, Koceila; André, Thierry; Arvieux, Catherine; Averous-Lang, Gerlinde; Bardier, Armelle; Rejeb, Houda Ben; Bereder, Jean-Marc; Bertheau, Philippe; Bibeau, Frédéric; Boige, Valérie; Bonnot, Pierre-Emmanuel; Bouché, Olivier; Bouhidel, Fatiha; Bouzard, Marie-Dominique; Brigand, Cécile; Broudin, Chloé; Celerier, Bertrand; Ceribelli, Cécilia; Charissoux, Aurélie; Chevallier, Anne; Clément, Elise; Coget, Julien; Courvoisier-Clément, Thomas; Dazza, Marie; de Chaisemartin, Cécile; Di Fiore, Frédéric; Dumont, Frédéric; Durand-Fontanier, Sylvaine; Eveno, Clarisse; Ezanno, Anne-Cécile; Facy, Olivier; Ferron, Gwenaël; Gagnière, Johann; Galan, Alexandre; Gelli, Maximiliano; Ghouti, Laurent; Gladieff, Laurence; Goere, Diane; Guilloit, Jean-Marc; Guyon, Frédéric; Heyd, Bruno; Heymann, Marie-Françoise; Hübner, Martin; Illac-Vauquelin, Claire; Kaci, Rachid; Kefleysus, Amaniel; Kianmanesh, Reza; Laverrière, Marie-Hélène; Lebrun-Ly, Valérie; Lefevre, Jérémie; Lelong, Bernard; Lemaistre, Anne-Isabelle; Malgras, Brice; Mariani, Pascale; Mariani, Antoine; Meeus, Pierre; Mery, Eliane; Narducci, Fabrice; Nougaret, Stéphanie; Orry, David; Ortega-Deballon, Pablo; Paquette, Brice; Péron, Julien; Peyrat, Patrice; Pezet, Denis; Pirro, Nicolas; Pocard, Marc; Poizat, Flora; Raimbourg, Judith; Rat, Patrick; Ries, Pauline; Rousset, Pascal; Sage, Pierre-Yves; Senellart, Hélène; Sgarbura, Olivia; Smolenschi, Cristina; Sourrouille, Isabelle; Taibi, Abdelkader; Tessier, Williams; Thibaudeau, Emilie; Touchefeu, Yann; Trilling, Bertrand; Tuech, Jean-Jacques; Valmary-Degano, Séverine; Varatharajah, Sharmini; Verriele-Beurrier, Véronique; Vogin, Guillaume; Wernert, Romuald; You, Benoit |
| Contributors: |
Hospices Civils de Lyon (HCL); Centre pour l'innovation en cancérologie de Lyon (CICLY); Université Claude Bernard Lyon 1 (UCBL); Université de Lyon-Université de Lyon; Institut Gustave Roussy (IGR); Département de biologie et pathologie médicales Gustave Roussy; Institut de Cancérologie de Lorraine - Alexis Vautrin Nancy (UNICANCER/ICL); UNICANCER; Centre de Recherche en Automatique de Nancy (CRAN); Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS); Département des Soins de Support Montpellier (Institut du Cancer); CRLCC Val d'Aurelle - Paul Lamarque; CHU Saint-Antoine AP-HP; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU); Centre hospitalier de Valence; Department of Surgery, Al-Amiri Hospital, Kuwait City; Département de médecine oncologique Gustave Roussy (DMO) |
| Source: |
ISSN: 1068-9265. |
| Publisher Information: |
CCSD; Springer Verlag |
| Publication Year: |
2024 |
| Collection: |
HAL Lyon 1 (University Claude Bernard Lyon 1) |
| Subject Terms: |
Cytoreduction; HIPEC; Mucinous tumor from teratoma; Ovarian carcinoma; Ovarian pseudomyxoma; Peritoneal pseudomyxoma; MESH: Female; MESH: Humans; MESH: Appendiceal Neoplasms; MESH: Combined Modality Therapy; MESH: Survival Rate; MESH: Middle Aged; MESH: Pseudomyxoma Peritonei; MESH: Hyperthermic Intraperitoneal Chemotherapy; MESH: Cytoreduction Surgical Procedures; MESH: Retrospective Studies; MESH: Hyperthermia; Induced; MESH: Neoplasms; Cystic; Mucinous; and Serous; MESH: Teratoma; [SDV]Life Sciences [q-bio] |
| Description: |
International audience ; Background: Ovarian pseudomyxoma peritonei (OPMP) are rare, without well-defined therapeutic guidelines. We aimed to evaluate cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) to treat OPMP.Methods: Patients from the French National Network for Rare Peritoneal Tumors (RENAPE) database with proven OPMP treated by CRS/HIPEC and with histologically normal appendix and digestive endoscopy were retrospectively included. Clinical and follow-up data were collected. Histopathological and immunohistochemical features were reviewed.Results: Fifteen patients with a median age of 56 years were included. The median Peritoneal Cancer Index was 16. Following CRS, the completeness of cytoreduction (CC) score was CC-0 for 9/15 (60%) patients, CC-1 for 5/15 (33.3%) patients, and CC-2 for 1/15 (6.7%) patients. The median tumor size was 22.5 cm. After pathological review and immunohistochemical studies, tumors were classified as Group 1 (mucinous ovarian epithelial neoplasms) in 3/15 (20%) patients; Group 2 (mucinous neoplasm in ovarian teratoma) in 4/15 (26.7%) patients; Group 3 (mucinous neoplasm probably arising in ovarian teratoma) in 5/15 (33.3%) patients; and Group 4 (non-specific group) in 3/15 (20%) patients. Peritoneal lesions were OPMP pM1a/acellular, pM1b/grade 1 (hypocellular) and pM1b/grade 3 (signet-ring cells) in 13/15 (86.7%), 1/15 (6.7%) and 1/15 (6.7%) patients, respectively. Disease-free survival analysis showed a difference (p = 0.0463) between OPMP with teratoma/likely-teratoma origin (groups 2 and 3; 100% at 1, 5, and 10 years), and other groups (groups 1 and 4; 100%, 66.6%, and 50% at 1, 5, and 10 years, respectively).Conclusion: These results suggested that a primary therapeutic strategy using complete CRS/HIPEC for patients with OPMP led to favorable long-term outcomes. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/38341381; PUBMED: 38341381; PUBMEDCENTRAL: PMC10997733 |
| DOI: |
10.1245/s10434-023-14850-0 |
| Availability: |
https://hal.science/hal-04838974; https://doi.org/10.1245/s10434-023-14850-0 |
| Accession Number: |
edsbas.B7B6B8C2 |
| Database: |
BASE |