| Title: |
On behalf of the North American Polyelectrolyte Producers Association (NAPPA), I hereby submit the attached manuscript entitled Induction of Tunica Vaginalis Mesotheliomas in |
| Authors: |
Designated Federal Officer (dfo |
| Contributors: |
The Pennsylvania State University CiteSeerX Archives |
| Source: |
http://yosemite.epa.gov/sab/sabproduct.nsf/3F36713160AFCB30852574EC0044B65C/$File/NAPPA+Comment+with+Study+SAB+10-28-08+Meeting.pdf. |
| Publication Year: |
2008 |
| Collection: |
CiteSeerX |
| Description: |
Rats by Xenobiotics. This manuscript, which was prepared by a series of prominent researchers lead by Dr. Robert Maronpot of Experimental Pathology Laboratories (EPL), was recently submitted to Critical Reviews in Toxicology. An early draft of this manuscript was provided to the SAB/EPA in July of this year. NAPPA wishes to bring this new manuscript to the SAB’s attention in the context of the Acrylamide Review Panel (ARP) report on acrylamide that will be reviewed on October 28. NAPPA sponsored this effort at EPL primarily to further expound on issues associated with the relevance of tunica vaginalis mesotheliomas (TVM) to human cancer risk, as well as to evaluate the suggestion in the ARP report that all chemicals that cause TVM tumors are mutagenic. As noted in response to question #18: The only agents known conclusively to induce tumors of the brain and peritesticular mesothelium in rats are all DNAreactive, and in fact a single exposure to a directacting mutagenic carcinogen has been observed to suffice for tumor induction at either site. As discussed in the attached manuscript, compounds that were found to exhibit robust TVM responses tended to be mutagenic in Salmonella but not in all cases. More importantly, only 2 of |
| Document Type: |
text |
| File Description: |
application/pdf |
| Language: |
English |
| Relation: |
http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.320.9709 |
| Availability: |
http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.320.9709; http://yosemite.epa.gov/sab/sabproduct.nsf/3F36713160AFCB30852574EC0044B65C/$File/NAPPA+Comment+with+Study+SAB+10-28-08+Meeting.pdf |
| Rights: |
Metadata may be used without restrictions as long as the oai identifier remains attached to it. |
| Accession Number: |
edsbas.B7CF1F87 |
| Database: |
BASE |