| Title: |
Exploring the Role of Lactoferrin in Managing Allergic Airway Diseases among Children: Unrevealing a Potential Breakthrough |
| Authors: |
Gori A.; Brindisi G.; Daglia M.; Giudice M. M. D.; Dinardo G.; Di Minno A.; Drago L.; Indolfi C.; Naso M.; Trincianti C.; Tondina E.; Brunese F. P.; Ullah H.; Varricchio A.; Ciprandi G.; Zicari A. M. |
| Contributors: |
A. Gori; G. Brindisi; M. Daglia; M.M.D. Giudice; G. Dinardo; A. Di Minno; L. Drago; C. Indolfi; M. Naso; C. Trincianti; E. Tondina; F.P. Brunese; H. Ullah; A. Varricchio; G. Ciprandi; A.M. Zicari |
| Publisher Information: |
MDPI |
| Publication Year: |
2024 |
| Collection: |
The University of Milan: Archivio Istituzionale della Ricerca (AIR) |
| Subject Terms: |
allergic rhiniti; anti-inflammatory; antioxidant; asthma; atopic disease; immunomodulation; lactoferrin; Settore MEDS-03/A - Microbiologia e microbiologia clinica |
| Description: |
The prevalence of allergic diseases has dramatically increased among children in recent decades. These conditions significantly impact the quality of life of allergic children and their families. Lactoferrin, a multifunctional glycoprotein found in various biological fluids, is emerging as a promising immunomodulatory agent that can potentially alleviate allergic diseases in children. Lactoferrin's multifaceted properties make it a compelling candidate for managing these conditions. Firstly, lactoferrin exhibits potent anti-inflammatory and antioxidant activities, which can mitigate the chronic inflammation characteristic of allergic diseases. Secondly, its iron-binding capabilities may help regulate the iron balance in allergic children, potentially influencing the severity of their symptoms. Lactoferrin also demonstrates antimicrobial properties, making it beneficial in preventing secondary infections often associated with respiratory allergies. Furthermore, its ability to modulate the immune response and regulate inflammatory pathways suggests its potential as an immune-balancing agent. This review of the current literature emphasises the need for further research to elucidate the precise roles of lactoferrin in allergic diseases. Harnessing the immunomodulatory potential of lactoferrin could provide a novel add-on approach to managing allergic diseases in children, offering hope for improved outcomes and an enhanced quality of life for paediatric patients and their families. As lactoferrin continues to capture the attention of researchers, its properties and diverse applications make it an intriguing subject of study with a rich history and a promising future. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/38931261; info:eu-repo/semantics/altIdentifier/wos/WOS:001256519500001; volume:16; issue:12; firstpage:1; lastpage:29; numberofpages:29; journal:NUTRIENTS; https://hdl.handle.net/2434/1162039 |
| DOI: |
10.3390/nu16121906 |
| Availability: |
https://hdl.handle.net/2434/1162039; https://doi.org/10.3390/nu16121906 |
| Rights: |
info:eu-repo/semantics/openAccess |
| Accession Number: |
edsbas.B7EE5ECE |
| Database: |
BASE |