| Title: |
PBR28 positron emission tomography signal as an imaging marker of joint inflammation in knee osteoarthritis |
| Authors: |
Sandstrom A.; Torrado-Carvajal A.; Morrissey E. J.; Kim M.; Alshelh Z.; Zhu Y.; Li M. D.; Chang C. Y.; Jarraya M.; Akeju O.; Schrepf A.; Harris R. E.; Kwon Y. -M.; Bedair H.; Chen A. F.; Mercaldo N. D.; Kettner N.; Napadow V.; Toschi N.; Edwards R. R.; Loggia M. L. |
| Contributors: |
Sandstrom, A; Torrado-Carvajal, A; Morrissey, Ej; Kim, M; Alshelh, Z; Zhu, Y; Li, Md; Chang, Cy; Jarraya, M; Akeju, O; Schrepf, A; Harris, Re; Kwon, Y-; Bedair, H; Chen, Af; Mercaldo, Nd; Kettner, N; Napadow, V; Toschi, N; Edwards, Rr; Loggia, Ml |
| Publisher Information: |
Lippincott Williams and Wilkins |
| Publication Year: |
2024 |
| Collection: |
Universitá degli Studi di Roma "Tor Vergata": ART - Archivio Istituzionale della Ricerca |
| Subject Terms: |
Inflammation; Knee osteoarthritis; Pain; Positron emission tomography; TSPO; Settore PHYS-06/A - Fisica per le scienze della vita; l'ambiente e i beni culturali |
| Description: |
Although inflammation is known to play a role in knee osteoarthritis (KOA), inflammation-specific imaging is not routinely performed. In this article, we evaluate the role of joint inflammation, measured using [11C]-PBR28, a radioligand for the inflammatory marker 18-kDa translocator protein (TSPO), in KOA. Twenty-one KOA patients and 11 healthy controls (HC) underwent positron emission tomography/magnetic resonance imaging (PET/MRI) knee imaging with the TSPO ligand [11C]-PBR28. Standardized uptake values were extracted from regions-of-interest (ROIs) semiautomatically segmented from MRI data, and compared across groups (HC, KOA) and subgroups (unilateral/bilateral KOA symptoms), across knees (most vs least painful), and against clinical variables (eg, pain and Kellgren-Lawrence [KL] grades). Overall, KOA patients demonstrated elevated [11C]-PBR28 binding across all knee ROIs, compared with HC (all P's < 0.005). Specifically, PET signal was significantly elevated in both knees in patients with bilateral KOA symptoms (both P's < 0.01), and in the symptomatic knee (P < 0.05), but not the asymptomatic knee (P = 0.95) of patients with unilateral KOA symptoms. Positron emission tomography signal was higher in the most vs least painful knee (P < 0.001), and the difference in pain ratings across knees was proportional to the difference in PET signal (r = 0.74, P < 0.001). Kellgren-Lawrence grades neither correlated with PET signal (left knee r = 0.32, P = 0.19; right knee r = 0.18, P = 0.45) nor pain (r = 0.39, P = 0.07). The current results support further exploration of [11C]-PBR28 PET signal as an imaging marker candidate for KOA and a link between joint inflammation and osteoarthritis-related pain severity. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/wos/WOS:001233772300002; volume:165; issue:5; firstpage:1121; lastpage:1130; numberofpages:10; journal:PAIN; https://hdl.handle.net/2108/403463 |
| DOI: |
10.1097/j.pain.0000000000003114 |
| Availability: |
https://hdl.handle.net/2108/403463; https://doi.org/10.1097/j.pain.0000000000003114 |
| Rights: |
info:eu-repo/semantics/openAccess ; license:Copyright dell'editore ; license uri:iris.publisher |
| Accession Number: |
edsbas.B841F2AC |
| Database: |
BASE |