| Title: |
OPA1-related dominant optic atrophy is not strongly influenced by mitochondrial DNA background. |
| Authors: |
Pierron, Denis; Ferré, Marc; Rocher, Christophe; Chevrollier, Arnaud; Murail, Pascal; Thoraval, Didier; Amati-Bonneau, Patrizia; Reynier, Pascal; Letellier, Thierry |
| Contributors: |
Physiopathologie mitochondriale; Université Bordeaux Segalen - Bordeaux 2-Institut National de la Santé et de la Recherche Médicale (INSERM); De la Préhistoire à l'Actuel : Culture, Environnement et Anthropologie (PACEA); Université de Bordeaux (UB)-Centre National de la Recherche Scientifique (CNRS); Institut de biochimie et génétique cellulaires (IBGC); Mitochondrie : Régulations et Pathologie; Université d'Angers (UA)-Institut National de la Santé et de la Recherche Médicale (INSERM); The authors specially thank the Association Française contre les Myopathies, INSERM, Université Victor Segalen Bordeaux-2, Aquitaine for financial support. D. Pierron was supported by a grant from the Association contre les Maladies Mitochondriales and a grant from the CNRS. The Pôle Génotypage - Séquençage was constituted thanks to grants from the Conseil Régional d'Aquitaine (n°20030304002FA and n°20040305003FA) and from the FEDER (n°2003227). |
| Source: |
ISSN: 1471-2350 ; BMC Medical Genetics ; https://inserm.hal.science/inserm-00663623 ; BMC Medical Genetics, 2009, 10 (1), pp.70. ⟨10.1186/1471-2350-10-70⟩. |
| Publisher Information: |
CCSD; BioMed Central |
| Publication Year: |
2009 |
| Subject Terms: |
mutations; optic neuropathies; OPA1 gene; autosomal dominant optic atrophy; mitochondrial DNA; MESH: Cohort Studies; MESH: DNA; Mitochondrial; MESH: Polymorphism; Restriction Fragment Length; MESH: France; MESH: GTP Phosphohydrolases; MESH: Haplotypes; MESH: Heterozygote; MESH: Humans; MESH: Mutation; MESH: Optic Atrophy; Autosomal Dominant; Hereditary; Leber; [SDV.GEN.GH]Life Sciences [q-bio]/Genetics/Human genetics; [SDV.MHEP.OS]Life Sciences [q-bio]/Human health and pathology/Sensory Organs |
| Description: |
International audience ; BACKGROUND: Leber's hereditary optic neuropathy (LHON) and autosomal dominant optic atrophy (ADOA) are the most frequent forms of hereditary optic neuropathies. LHON is associated with mitochondrial DNA (mtDNA) mutations whereas ADOA is mainly due to mutations in the OPA1 gene that encodes a mitochondrial protein involved in the mitochondrial inner membrane remodeling. A striking influence of mtDNA haplogroup J on LHON expression has been demonstrated and it has been recently suggested that this haplogroup could also influence ADOA expression. In this study, we have tested the influence of mtDNA backgrounds on OPA1 mutations. METHODS: To define the relationships between OPA1 mutations and mtDNA backgrounds, we determined the haplogroup affiliation of 41 French patients affected by OPA1-related ADOA by control-region sequencing and RFLP survey of their mtDNAs. RESULTS: The comparison between patient and reference populations did not revealed any significant difference. CONCLUSION: Our results argue against a strong influence of mtDNA background on ADOA expression. These data allow to conclude that OPA1 could be considered as a "severe mutation", directly responsible of the optic atrophy, whereas OPA1-negative ADOA and LHON mutations need an external factor(s) to express the pathology (i.e. synergistic interaction with mitochondrial background). |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/19619285; PUBMED: 19619285 |
| DOI: |
10.1186/1471-2350-10-70 |
| Availability: |
https://inserm.hal.science/inserm-00663623; https://inserm.hal.science/inserm-00663623v1/document; https://inserm.hal.science/inserm-00663623v1/file/1471-2350-10-70.pdf; https://doi.org/10.1186/1471-2350-10-70 |
| Rights: |
info:eu-repo/semantics/OpenAccess |
| Accession Number: |
edsbas.B850302 |
| Database: |
BASE |