| Title: |
Long-Term Outcomes of Brugada Substrate Ablation: A Report from BRAVO (Brugada Ablation of VF Substrate Ongoing Multicenter Registry). |
| Authors: |
Nademanee, K; Chung, F-P; Sacher, F; Nogami, A; Nakagawa, H; Jiang, C; Hocini, M; Behr, E; Veerakul, G; Jan Smit, J; Wilde, AAM; Chen, S-A; Yamashiro, K; Sakamoto, Y; Morishima, I; Das, MK; Khongphatthanayothin, A; Vardhanabhuti, S; Haissaguerre, M |
| Publisher Information: |
American Heart Association |
| Publication Year: |
2023 |
| Collection: |
St George's University of London: Repository |
| Description: |
BACKGROUND: Treatment options for high-risk Brugada syndrome (BrS) with recurrent ventricular fibrillation (VF) are limited. Catheter ablation is increasingly performed but a large study with long-term outcome data is lacking. We report the results of the multicenter, international BRAVO (Brugada Ablation of VF Substrate Ongoing Registry) for treatment of high-risk symptomatic BrS. METHODS: We enrolled 159 patients (median age 42 years; 156 male) with BrS and spontaneous VF in BRAVO; 43 (27%) of them had BrS and early repolarization pattern. All but 5 had an implantable cardioverter-defibrillator for cardiac arrest (n=125) or syncope (n=34). A total of 140 (88%) had experienced numerous implantable cardioverter-defibrillator shocks for spontaneous VF before ablation. All patients underwent a percutaneous epicardial substrate ablation with electroanatomical mapping except for 8 who underwent open-thoracotomy ablation. RESULTS: In all patients, VF/BrS substrates were recorded in the epicardial surface of the right ventricular outflow tract; 45 (29%) patients also had an arrhythmic substrate in the inferior right ventricular epicardium and 3 in the posterior left ventricular epicardium. After a single ablation procedure, 128 of 159 (81%) patients remained free of VF recurrence; this number increased to 153 (96%) after a repeated procedure (mean 1.2±0.5 procedures; median=1), with a mean follow-up period of 48±29 months from the last ablation. VF burden and frequency of shocks decreased significantly from 1.1±2.1 per month before ablation to 0.003±0.14 per month after the last ablation (P |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| ISSN: |
1524-4539 |
| Relation: |
https://openaccess.sgul.ac.uk/id/eprint/115283/13/CIRCULATIONAHA.122.063367.pdf; https://openaccess.sgul.ac.uk/id/eprint/115283/8/circ_circulationaha-2022-063367_supp1.pdf; Nademanee, K; Chung, F-P; Sacher, F; Nogami, A; Nakagawa, H; Jiang, C; Hocini, M; Behr, E; Veerakul, G; Jan Smit, J; et al. Nademanee, K; Chung, F-P; Sacher, F; Nogami, A; Nakagawa, H; Jiang, C; Hocini, M; Behr, E; Veerakul, G; Jan Smit, J; Wilde, AAM; Chen, S-A; Yamashiro, K; Sakamoto, Y; Morishima, I; Das, MK; Khongphatthanayothin, A; Vardhanabhuti, S; Haissaguerre, M (2023) Long-Term Outcomes of Brugada Substrate Ablation: A Report from BRAVO (Brugada Ablation of VF Substrate Ongoing Multicenter Registry). Circulation, 147 (21). pp. 1568-1578. ISSN 1524-4539 https://doi.org/10.1161/CIRCULATIONAHA.122.063367 SGUL Authors: Behr, Elijah Raphael |
| DOI: |
10.1161/CIRCULATIONAHA.122.063367 |
| Availability: |
https://openaccess.sgul.ac.uk/id/eprint/115283/; https://openaccess.sgul.ac.uk/id/eprint/115283/13/CIRCULATIONAHA.122.063367.pdf; https://doi.org/10.1161/CIRCULATIONAHA.122.063367 |
| Rights: |
cc_by_nc_4 |
| Accession Number: |
edsbas.B8AED68D |
| Database: |
BASE |