| Title: |
Post-consultation acute respiratory tract infection recovery: a latent class-informed analysis of individual patient data |
| Authors: |
Hounkpatin, Hilda; Stuart, Beth; Zhu, Shihua; Yao, Guiqing Lily; Moore, Michael; Loffler, Christin; Little, Paul; Kenealy, Timothy; Gillespie, David; Francis, N.A.; Bostock, Jennifer; Becque, Taeko; Arroll, Bruce; Altiner, Attila; Alonso-Coello, Pablo; Hay, Alastair D. |
| Publication Year: |
2023 |
| Collection: |
University of Southampton: e-Prints Soton |
| Description: |
Background: there is a lack of evidence regarding post-consultation symptom trajectories for patients with respiratory tract infections (RTIs) and whether patient characteristics can be used to predict illness duration. Aim: to describe symptom trajectories in patients with RTIs, and assess baseline characteristics and adverse events associated with trajectories. Design and setting: the study included data about 9103 adults and children from 12 primary care studies. Method: a latent class-informed regression analysis of individual patient data from randomised controlled trials and observational cohort studies was undertaken. Post-consultation symptom trajectory (severity and duration), re-consultation with same or worsening illness, and admission to hospital were assessed. Results: in total, 90% of participants recovered from all symptoms by 28 days, regardless of antibiotic prescribing strategy (none, immediate, and delayed antibiotics). For studies of RTI with cough as a dominant symptom (n = 5314), four trajectories were identified: ‘rapid (6 days)’ (90% of participants recovered within 6 days) in 52.0%; ‘intermediate (10 days)’ (28.9%); ‘slow progressive improvement (27 days)’ (12.5%); and ‘slow improvement with initial high symptom burden (27 days)’ (6.6%). For cough, being aged 16–64 years (odds ratio [OR] 2.57, 95% confidence interval [CI] = 1.72 to 3.85 compared with 10 days) compared with faster recovery (≤10 days). Re-consultations and admissions to hospital for cough were higher in those with slower recovery (ORs: 2.15, 95% CI = 1.78 to 2.60 and 7.42, 95% CI = 3.49 to 15.78, respectively). Conclusion: older patients presenting with more severe, longer pre-consultation symptoms and chronic lung disease should be ... |
| Document Type: |
article in journal/newspaper |
| File Description: |
text |
| Language: |
English |
| Relation: |
https://eprints.soton.ac.uk/475211/1/IPD_tajectories_paper_R1_4Oct22.docx; https://eprints.soton.ac.uk/475211/2/e196.full.pdf; Hounkpatin, Hilda, Stuart, Beth, Zhu, Shihua, Yao, Guiqing Lily, Moore, Michael, Loffler, Christin, Little, Paul, Kenealy, Timothy, Gillespie, David, Francis, N.A., Bostock, Jennifer, Becque, Taeko, Arroll, Bruce, Altiner, Attila, Alonso-Coello, Pablo and Hay, Alastair D. (2023) Post-consultation acute respiratory tract infection recovery: a latent class-informed analysis of individual patient data. British Journal of General Practice, 73 (728), E196-E203. (doi:10.3399/BJGP.2022.0229 ). |
| Availability: |
https://eprints.soton.ac.uk/475211/; https://eprints.soton.ac.uk/475211/1/IPD_tajectories_paper_R1_4Oct22.docx; https://eprints.soton.ac.uk/475211/2/e196.full.pdf |
| Rights: |
cc_by_4 |
| Accession Number: |
edsbas.B8C82EC7 |
| Database: |
BASE |