| Title: |
Cyclopropyl building blocks for organic synthesis, part 75. Domino reactions of amidines with methyl 2-chloro-2-cyclopropylideneacetate as an efficient access to cyclobutene-annelated pyrimidinones |
| Authors: |
Notzel, M. W.; Rauch, K.; Labahn, T.; de Meijere, Armin |
| Contributors: |
Notzel, M. W.; Rauch, K.; Labahn, T.; de Meijere, Armin |
| Publisher Information: |
Amer Chemical Soc |
| Publication Year: |
2002 |
| Collection: |
Georg-August-Universität Göttingen: GoeScholar |
| Description: |
An efficient one-step synthesis of 2,4-diazabicyclo[4.2.0]octa-1 (6),2-dien-5-ones 3 from methyl 2-chloro-2-cyclopropylideneacetate (1) and amidines 2a-c as well as N,N-dimethylguanidine (2d) is described, Similar to the benzocyclobutenes, the cyclobutene-annelated pyrimidones 3 undergo thermal ring opening and the resulting o-quinodimethane analogues readily cycloadd dienophiles to yield tetrahydroquinazolone derivatives. |
| Document Type: |
article in journal/newspaper |
| Language: |
unknown |
| Relation: |
000174253600044 |
| Availability: |
https://resolver.sub.uni-goettingen.de/purl?gro-2/44043 |
| Rights: |
info:eu-repo/semantics/openAccess |
| Accession Number: |
edsbas.B90C5079 |
| Database: |
BASE |