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Divergent clonal selection dominates medulloblastoma at recurrence

Title:	Divergent clonal selection dominates medulloblastoma at recurrence
Authors:	Morrissy AS; Garzia L; Shih DJH; Zuyderduyn S; Huang X; Skowron P; Remke M; Cavalli FMG; Ramaswamy V; Lindsay PE; Jelveh S; Donovan LK; Wang X; Luu B; Zayne K; Li YS; Mayoh C; Thiessen N; Mercier E; Mungall KL; Ma Y; Tse K; Zeng T; Shumansky K; Roth AJL; Shah S; Farooq H; Kijima N; Holgado BL; Lee JJY; Matan-Lithwick S; Liu J; Mack SC; Manno A; Michealraj KA; Nor C; Peacock J; Qin L; Reimand J; Rolider A; Thompson YY; Wu XC; Pugh T; Ally A; Bilenky M; Butterfield YSN; Carlsen R; Cheng Y; Chuah E; Corbett RD; Dhalla N; He A; Lee D; Li HYI; Long W; Mayo M; Plettner P; Qian JQ; Schein JE; Tam A; Wong T; Birol I; Zhao YJ; Faria CC; Pimentel J; Nunes S; Shalaby T; Grotzer M; Pollack IF; Hamilton RL; Li XN; Bendel AE; Fults DW; Walter AW; Kumabe T; Tominaga T; Collins VP; Cho YJ; Hoffman C; Lyden D; Wisoff JH; Garvin JH; Stearns DS; Massimi L; Schuller U; Sterba J; Zitterbart K; Puget S; Ayrault O; Dunn SE; Tirapelli DPC; Carlotti CG; Wheeler H; Hallahan AR; Ingram W; MacDonald TJ; Olson JJ; Van Meir EG; Lee JY; Wang KC; Kim SK; Cho BK; Pietsch T; Fleischhack G; Tippelt S; Ra YS; Bailey S; Lindsey JC; Clifford SC; Eberhart CG; Cooper MK; Packer RJ; Massimino M; Garre ML; Bartels U; Tabori U; Hawkins CE; Dirks P; Bouffet E; Rutka JT; Wechsler-Reya RJ; Weiss WA; Collier LS; Dupuy AJ; Korshunov A; Jones DTW; Kool M; Northcott PA; Pfister SM; Largaespada DA; Mungall AJ; Moore RA; Jabado N; Bader GD; Jones SJM; Malkin D; Marra MA; Taylor MD
Source:	Nature
Publisher Information:	Nature Publishing Group
Collection:	Newcastle University Library ePrints Service
Description:	The development of targeted anti-cancer therapies through the study of cancer genomes is intended to increase survival rates and decrease treatment-related toxicity. We treated a transposon-driven, functional genomic mouse model of medulloblastoma with 'humanized' in vivo therapy (microneurosurgical tumour resection followed by multi-fractionated, image-guided radiotherapy). Genetic events in recurrent murine medulloblastoma exhibit a very poor overlap with those in matched murine diagnostic samples (
Document Type:	article in journal/newspaper
Language:	unknown
Relation:	https://eprints.ncl.ac.uk/219195
Availability:	https://eprints.ncl.ac.uk/219195
Accession Number:	edsbas.B978ADAE
Database:	BASE