haematologica/the hematology journal | 2005; 90(10) | 1415
| Title: | haematologica/the hematology journal | 2005; 90(10) | 1415 |
|---|---|
| Authors: | Bregje Mommaas; Astrid G. S. Van Halteren; Jos Pool; Lars Van Der Veken; Brigitte Wieles; Mirjam H. M. Heemskerk; Els Goulmy |
| Contributors: | The Pennsylvania State University CiteSeerX Archives |
| Source: | http://www.haematologica.org/content/90/10/1415.full.pdf. |
| Collection: | CiteSeerX |
| Description: | Adult and cord blood T cells can acquire HA-1 specificity through HA-1 T-cell receptor gene transfer The minor histocompatibility anti-gen (mHag) HA-1 is a polymorphicantigen that is presented in the con-text of HLA-A2.1 The tissue distribution of HA-1 is restricted to hematopoietic cells and carcinomas.2,3 It can, therefore, func-tion as a tumor target antigen for stem cell based immunotherapy of malignancies. In the setting of HLA-matched HA-1-mis-matched stem cell transplantation (SCT) for hematologic malignancies, T cells from the HA-1neg stem cell donor can recognize HA-1 expressed by the patient's leukemic cells.4 In vivo and in vitro generation of HLA-A2-restricted HA-1-specific cytotox- |
| Document Type: | text |
| File Description: | application/pdf |
| Language: | English |
| Relation: | http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.541.8391; http://www.haematologica.org/content/90/10/1415.full.pdf |
| Availability: | http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.541.8391; http://www.haematologica.org/content/90/10/1415.full.pdf |
| Rights: | Metadata may be used without restrictions as long as the oai identifier remains attached to it. |
| Accession Number: | edsbas.B9800C5D |
| Database: | BASE |